公开(公告)号：US20130053304A1

公开(公告)日：2013-02-28

申请号：US13643840

申请日：2011-04-29

申请人： Yinxiang Wang ,  Fenlai Tan ,  Shaojing Hu ,  Xiangdong Zhao ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Lieming Ding ,  Yunyan Hu ,  Hong Cao ,  Wei Long

发明人： Yinxiang Wang ,  Fenlai Tan ,  Shaojing Hu ,  Xiangdong Zhao ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Lieming Ding ,  Yunyan Hu ,  Hong Cao ,  Wei Long

IPC分类号： A61K38/26 ,  A61P3/10 ,  A61P3/08 ,  A61P3/04 ,  A61P9/12 ,  A61P1/04 ,  A61P25/00 ,  A61P9/10 ,  A61P9/00 ,  A61P7/02 ,  A61P1/00 ,  C07K14/605 ,  A61P3/06

CPC分类号： C07K14/605 ,  A61K38/00

摘要： Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar.

摘要翻译： 本发明提供如下式所示的胰高血糖素样肽-1（GLP-1）类似物，其中X选自甘氨酸和甘氨酰胺。 GLP-1类似物相对于序列GLP-1具有位置8的非蛋白原性氨基酸残基，并且用包含两个酸性基团的部分酰化至位置26的赖氨酸残基。GLP-1类似物对 二肽基肽酶IV，以使体内延长半衰期。 还提供了GLP-1类似物在征服血糖中的用途。

公开(公告)号：US20120323237A1

公开(公告)日：2012-12-20

申请号：US13593676

申请日：2012-08-24

申请人： Saurav Paul ,  Hong Cao ,  Kedar Ravindra Belhe ,  Chou Thao

发明人： Saurav Paul ,  Hong Cao ,  Kedar Ravindra Belhe ,  Chou Thao

IPC分类号： A61B18/14

CPC分类号： A61B18/1206 ,  A61B5/0538 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00732 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/128

摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

摘要翻译： 公开了电极导管和用于评估电极组织接触和耦合的方法。 示例性电极导管包括适于施加电能的电极。 测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。 处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。 在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

公开(公告)号：US08255035B2

公开(公告)日：2012-08-28

申请号：US11967518

申请日：2007-12-31

申请人： Hong Cao ,  Saurav Paul ,  Chou Thao

发明人： Hong Cao ,  Saurav Paul ,  Chou Thao

IPC分类号： A61B5/042

CPC分类号： A61B17/3478 ,  A61B18/1477 ,  A61B2017/00247 ,  A61B2017/00256 ,  A61B2018/00392 ,  A61B2018/00839 ,  A61B2018/1425 ,  A61B2034/2051

摘要： A needle for a medical procedure includes a shaft with an inner surface, an outer surface, a proximal section, and a distal section. The distal section has a conductive tip configured to be a first electrode for voltage measurement. The needle further includes a first electrically insulative outer layer over a portion of the outer surface of the shaft. The conductive tip is adapted for insertion through tissue into, for example, a pericardial space of a patient. A system for determining the location of a needle during a medical procedure includes the needle and an anatomical mapping and localization system electrically coupled to the needle and adapted to measure voltage at the conductive tip. A system for determining tissue thickness during a medical procedure includes the needle, an anatomical mapping and localization system electrically coupled to the needle, and an electrocardiograph operatively coupled to the needle and adapted to monitor electrical activity at the conductive tip and at the second electrode. The needle may include a second electrode.

摘要翻译： 用于医疗程序的针包括具有内表面的轴，外表面，近侧部分和远侧部分。 远侧部分具有被配置为用于电压测量的第一电极的导电尖端。 针还包括在轴的外表面的一部分上的第一电绝缘外层。 导电尖端适于将组织插入到例如患者的心包空间中。 用于在医疗过程中确定针的位置的系统包括针和解耦映射和定位系统，其电耦合到针并且适于测量导电尖端处的电压。 用于在医疗过程中确定组织厚度的系统包括针，电耦合到针的解剖学映射和定位系统以及可操作地耦合到针并且适于监测导电尖端和第二电极处的电活动的心电图仪。 针可以包括第二电极。

公开(公告)号：US08162935B2

公开(公告)日：2012-04-24

申请号：US12091151

申请日：2006-10-27

申请人： Saurav Paul ,  Troy T. Tegg ,  Chou Thao ,  Hong Cao ,  Harry Puryear ,  Fos Kuehn ,  Reed R. Heimbecher

发明人： Saurav Paul ,  Troy T. Tegg ,  Chou Thao ,  Hong Cao ,  Harry Puryear ,  Fos Kuehn ,  Reed R. Heimbecher

IPC分类号： A61B18/14 ,  A61B5/04

CPC分类号： A61B18/1492 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2090/065

摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode 10 housed within a distal portion of a catheter shaft 14. At least one electro-mechanical sensor 20 is operatively associated with the electrode 10 within the catheter shaft 14. The at least one electro-mechanical sensor 20 is responsive to movement of the electrode 10 by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electro-mechanical sensor 20. The output device receives the electrical signals for assessing a level of contact between the electrode 10 and a tissue 12.

摘要翻译： 公开了用于评估用于组织消融的电极组织接触的系统和方法。 示例性的电极接触感测系统包括容纳在导管轴14的远端部分内的电极10.至少一个电 - 机械传感器20与导管轴14内的电极10可操作地相关联。至少一个电 - 机械传感器 20通过产生对应于移动量的电信号来响应于电极10的运动。 该系统还可以包括电连接到至少一个机电传感器20的输出装置。输出装置接收用于评估电极10和组织12之间的接触程度的电信号。

公开(公告)号：US07955326B2

公开(公告)日：2011-06-07

申请号：US11647316

申请日：2006-12-29

申请人： Saurav Paul ,  Kedar Ravindra Belhe ,  Chou Thao ,  Hong Cao

发明人： Saurav Paul ,  Kedar Ravindra Belhe ,  Chou Thao ,  Hong Cao

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00791 ,  A61B2018/1437 ,  A61B2090/064 ,  A61B2090/065 ,  A61B2218/002

摘要： The present invention is directed to ablation devices and methods utilizing pressure sensitive conductive composites, such as quantum tunneling composites, or other contact-sensitive, conductive polymers. The materials provide for electrodes and methods capable of differentiating between a soft and a hard push. The present invention thus provides an electrode for delivering selective electrical energy for ablation that may be varied based upon the pressure exerted on the surface area of the targeted tissue.

摘要翻译： 本发明涉及使用压敏导电复合材料如量子隧道复合材料或其它接触敏感的导电聚合物的消融装置和方法。 这些材料提供了能够区分软推和硬推的电极和方法。 因此，本发明提供了一种用于输送用于消融的选择性电能的电极，其可以基于施加在目标组织的表面积上的压力而变化。

公开(公告)号：US07883508B2

公开(公告)日：2011-02-08

申请号：US11647294

申请日：2006-12-29

申请人： Chou Thao ,  Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao

发明人： Chou Thao ,  Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2090/064

摘要： A catheter assembly for pressure-sensitive control of ablation treatment is disclosed. The assembly includes a conductive element, an electrode, and a pressure sensitive conductive composite member positioned between the conductive element and the electrode. At least one of the conductive pin, the pressure sensitive conductive composite element and the ablation electrode are moveable to create an engagement position and a non-engagement position. In the engagement position, the elements are electrically coupled such that ablation energy may be delivered from the conductive pin to the ablation electrode via the pressure sensitive conductive composite element. In the non-engagement position, the elements are electrically decoupled such that ablation energy is not delivered to the ablation electrode. A related method for pressure-sensitive control of ablation is also disclosed.

摘要翻译： 公开了一种用于消融治疗的压敏控制的导管组件。 组件包括导电元件，电极和位于导电元件和电极之间的压敏导电复合元件。 导电针，压敏导电复合元件和消融电极中的至少一个可移动以产生接合位置和非接合位置。 在接合位置，元件被电耦合，使得消融能量可以经由压敏导电复合元件从导电引脚传送到消融电极。 在非接合位置，元件被电去耦合，使得消融能量不被输送到消融电极。 还公开了一种用于消融的压敏控制的相关方法。

公开(公告)号：US20100286690A1

公开(公告)日：2010-11-11

申请号：US12095685

申请日：2006-12-06

申请人： Saurav Paul ,  Hong Cao ,  Chou Thao

发明人： Saurav Paul ,  Hong Cao ,  Chou Thao

IPC分类号： A61B18/14

CPC分类号： A61N1/40 ,  A61B2018/00357 ,  A61B2018/00875

摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

公开(公告)号：US07591816B2

公开(公告)日：2009-09-22

申请号：US11646270

申请日：2006-12-28

申请人： Huisun Wang ,  Hong Cao

发明人： Huisun Wang ,  Hong Cao

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2090/065 ,  A61B2218/002

摘要： The invention relates to an irrigated ablation catheter that has a pressure sensor to determine tissue contact as well as methods of using the same. The irrigated ablation catheter contains fluid tubing, an electrode with passages and a lumen and a pressure sensor located inside the lumen of the electrode. In some embodiments, a cooling fluid, such as saline, is passed through the catheter.

摘要翻译： 本发明涉及一种具有确定组织接触的压力传感器的灌洗消融导管及其使用方法。 灌注消融导管包含流体管，具有通道的电极和内腔，位于电极内腔内的压力传感器。 在一些实施例中，诸如盐水的冷却流体通过导管。

公开(公告)号：US20080275442A1

公开(公告)日：2008-11-06

申请号：US12091151

申请日：2006-10-27

申请人： Saurav Paul ,  Troy T. Tegg ,  Chou Thao ,  Hong Cao ,  Harry Puryear ,  Fos Kuehn ,  Reed R. Heimbecher

发明人： Saurav Paul ,  Troy T. Tegg ,  Chou Thao ,  Hong Cao ,  Harry Puryear ,  Fos Kuehn ,  Reed R. Heimbecher

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2090/065

摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode 10 housed within a distal portion of a catheter shaft 14. At least one electromechanical sensor 20 is operatively associated with the electrode 10 within the catheter shaft 14. The at least one electromechanical sensor 20 is responsive to movement of the electrode 10 by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electromechanical sensor 20. The output device receives the electrical signals for assessing a level of contact between the electrode 10 and a tissue 12.

摘要翻译： 公开了用于评估用于组织消融的电极组织接触的系统和方法。 示例性电极接触感测系统包括容纳在导管轴14的远端部分内的电极10。 至少一个机电传感器20与导管轴14内的电极10可操作地相关联。 至少一个机电传感器20通过产生对应于移动量的电信号来响应电极10的运动。 该系统还可以包括电连接到至少一个机电传感器20的输出装置。 输出装置接收用于评估电极10和组织12之间的接触水平的电信号。

公开(公告)号：US07326204B2

公开(公告)日：2008-02-05

申请号：US10808919

申请日：2004-03-24

申请人： Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao ,  Chou Thao

发明人： Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao ,  Chou Thao

IPC分类号： A61B18/18

CPC分类号： A61B18/1402 ,  A61B2018/143 ,  A61B2018/1472

摘要： A brush electrode and a method for using the brush electrode for tissue ablation are disclosed. The brush electrode comprises a plurality of flexible filaments or bristles for applying ablative energy (e.g., RF energy) to target tissue during the formation of spot or continuous linear lesions. Interstitial spaces are defined among the filaments of the brush electrode, and the interstitial spaces are adapted to direct conductive or nonconductive fluid, when present, toward the distal ends of the brush filaments. The brush electrode facilitates electrode-tissue contact in target tissue having flat or contoured surfaces. The flexible filaments may be selectively trimmed to give a desired tip configuration or a desired standoff distance between the tissue and the conductive filaments in the brush electrode. Also, the filaments may be grouped into clusters. A shielded-tip brush electrode, including a flexible boot, is also disclosed.