Ultrasound ionization mass spectrometer
    21.
    发明申请
    Ultrasound ionization mass spectrometer 有权
    超声电离质谱仪

    公开(公告)号:US20100301199A1

    公开(公告)日:2010-12-02

    申请号:US12457064

    申请日:2009-05-29

    IPC分类号: B01D59/44 H01J49/00

    CPC分类号: H01J49/10 H01J49/0454

    摘要: Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, including biological macromolecules and nanoparticles, can be achieved. Ionization efficiency can be improved by addition of chemicals such as, for example, organic solvents or acids to the sample.

    摘要翻译: 提供了超声电离质谱法的方法和系统。 样品中的分析物通过对其进行超声波离子化,便于通过质谱法进行分析。 通过这些方法和系统,可以实现大分子的软电离,包括生物大分子和纳米颗粒。 通过向样品中加入化学物质,例如有机溶剂或酸,可以提高电离效率。

    Acoustic desorption mass spectrometry
    22.
    发明授权
    Acoustic desorption mass spectrometry 有权
    声解吸质谱

    公开(公告)号:US07645987B2

    公开(公告)日:2010-01-12

    申请号:US11234051

    申请日:2005-09-22

    IPC分类号: B01D59/44 H01J49/00

    CPC分类号: H01J49/16 H01J49/0454

    摘要: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.

    摘要翻译: 一种生产气相分子的方法包括提供分子样品,该样品的特征在于电荷分布,并引导分子样品上的声辐射以从样品解吸至少一些分子,使得解吸的分子具有 电荷分布基本上与分子样品的电荷分布相同。

    In-Solution Microarray Assay
    23.
    发明申请
    In-Solution Microarray Assay 审中-公开
    解决方案微阵列测定

    公开(公告)号:US20080188374A1

    公开(公告)日:2008-08-07

    申请号:US12022553

    申请日:2008-01-30

    IPC分类号: C40B20/00 C40B60/10

    CPC分类号: C40B40/06 C40B20/04 C40B60/10

    摘要: This invention relates to a kit and a system for performing an in-solution microarray assay, and a method of carrying out this assay. The kit includes a plate having a number of wells in which a plurality of magnetic beads are placed. These magnetic beads are coated with different probes, wherein beads placed in each individual well are coated with identical probes.

    摘要翻译: 本发明涉及用于进行溶液中微阵列测定的试剂盒和系统,以及进行该测定的方法。 该套件包括具有许多孔的板,其中放置有多个磁珠。 这些磁珠用不同的探针涂覆,其中放置在每个单独的孔中的珠子用相同的探针包被。

    Dual-polarity mass spectrometer
    24.
    发明申请
    Dual-polarity mass spectrometer 有权
    双极性质谱仪

    公开(公告)号:US20080078928A1

    公开(公告)日:2008-04-03

    申请号:US11542568

    申请日:2006-10-03

    IPC分类号: H01J49/40

    CPC分类号: H01J49/40 H01J49/0095

    摘要: A dual-polarity mass spectrometer includes an ion source, a negative ion mass analyzer, and a positive ion mass analyzer to measure both the negative and positive ion spectra of a sample material simultaneously. The ion source includes a sample surface on which the sample material is positioned, the sample material providing positive ions and negative ions when excited by a laser beam or an energetic particle stream. A first extraction electrode is connected to a voltage higher than the sample surface to attract the negative ions from the sample electrode. A second extraction electrode is connected to a voltage lower than the sample surface to attract the positive ions from the sample electrode. The negative and positive ions are analyzed simultaneously by the negative ion mass analyzer and the positive ion mass analyzer, respectively.

    摘要翻译: 双极性质谱仪包括离子源,负离子质量分析仪和正离子质量分析仪,以同时测量样品材料的负离子和正离子光谱。 离子源包括其上放置样品材料的样品表面,当由激光束或能量粒子流激发时,样品材料提供正离子和负离子。 第一引出电极连接到高于样品表面的电压以吸引来自样品电极的负离子。 第二提取电极连接到低于样品表面的电压,以吸引来自样品电极的正离子。 负离子和正离子分别通过负离子质量分析仪和正离子质量分析仪同时分析。

    Acoustic desorption mass spectrometry
    25.
    发明申请
    Acoustic desorption mass spectrometry 有权
    声解吸质谱

    公开(公告)号:US20070131871A1

    公开(公告)日:2007-06-14

    申请号:US11234051

    申请日:2005-09-22

    IPC分类号: H01J27/00

    CPC分类号: H01J49/16 H01J49/0454

    摘要: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.

    摘要翻译: 一种生产气相分子的方法包括提供分子样品,该样品的特征在于电荷分布,并引导分子样品上的声辐射以从样品解吸至少一些分子,使得解吸的分子具有 电荷分布基本上与分子样品的电荷分布相同。