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公开(公告)号：US20210256688A1
公开(公告)日：2021-08-19
申请号：US16929080
申请日：2020-07-14
Inventor： Syu-Jyun PENG , Yu-Wei CHEN , Jing-Yu YANG , Jang-Zern TSAI , Kuo-Wei WANG , Yeh-Lin KUO
Abstract: The present disclosure provides an operating method of a system for analyzing brain tissue based on computerized tomographic imaging, and the operation method includes steps as follows. A computed tomography image of a subject is aligned to a predetermined standard brain space image, to obtain a first normalized test computed tomography image. A voxel contrast of the first normalized test computed tomography image is enhanced to obtain an enhanced first normalized test computed tomography image. The enhanced first normalized test computed tomography image is aligned to an average computed tomographic image of a control group to obtain a second normalized test computed tomography image. An analysis based on the second normalized test computed tomography image and a plurality of computerized tomographic images of the control group is performed to obtain a t-score map.
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公开(公告)号：US20160035085A1
公开(公告)日：2016-02-04
申请号：US14642761
申请日：2015-03-10
Applicant: Huan-Cheng Chang , National Central University
Inventor： Syu-Jyun PENG , Jang-Zern TSAI , Yu-Wei CHEN , Kuo-Wei WANG
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/055 , A61B5/4064 , G06T7/11 , G06T7/136 , G06T2207/10088 , G06T2207/30016
Abstract: A method for detecting a cerebral infarct includes receiving an image of a brain of a subject from a magnetic resonance imaging scanner, wherein the image has a plurality of voxels, and each of the voxels has a voxel intensity. Then, the voxel intensities are normalized, wherein the normalized voxel intensities have a distribution peak, and the normalized voxel intensity of the distribution peak is Ipeak. A threshold is determined, which is the Ipeak+ a value. Voxel having the normalized voxel intensity larger than the threshold is selected, wherein the selected voxel is the cerebral infarct. A method for quantifying the cerebral infarct is also provided.
Abstract translation: 检测脑梗塞的方法包括从磁共振成像扫描仪接收被检者的脑部图像，其中，图像具有多个体素，并且每个体素具有体素强度。 然后，体素强度被归一化，其中归一化体素强度具有分布峰，并且分布峰的归一化体素强度为Ipeak。 确定阈值，即Ipeak + a值。 选择具有大于阈值的归一化体素强度的体素，其中所选择的体素是脑梗死。 还提供了定量脑梗塞的方法。
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3.发明授权公开(公告)号：US08963075B2
公开(公告)日：2015-02-24
申请号：US12314520
申请日：2008-12-11
Applicant: Chung Hsuan Chen , Wen-Ping Peng , Ming Lee Chu , Huan Cheng Chang , Huan-Chang Lin
Inventor： Chung Hsuan Chen , Wen-Ping Peng , Ming Lee Chu , Huan Cheng Chang , Huan-Chang Lin
CPC classification number: H01J49/4265 , H01J49/0077 , H01J49/025
Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
Abstract translation: 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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公开(公告)号：US08168413B2
公开(公告)日：2012-05-01
申请号：US11939311
申请日：2007-11-13
Applicant: Huan-Cheng Chang , Wunshain Fann , Chau-Chung Han
Inventor： Huan-Cheng Chang , Wunshain Fann , Chau-Chung Han
CPC classification number: C09K11/65 , C01B32/28 , Y10T428/2982
Abstract: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm and the ion beam has a kinetic energy of 1 KeV to 900 MeV. Also disclosed are luminescent diamond particles prepared by this method and methods of using them.
Abstract translation: 制备发光金刚石颗粒（例如荧光纳米金刚石）的方法。 该方法包括用离子束照射金刚石颗粒并在600-1000℃的温度下在非氧化性气氛中加热照射的金刚石颗粒。金刚石颗粒的直径为1nm至1mm，离子束具有 1 KeV至900 MeV的动能。 还公开了通过该方法制备的发光金刚石颗粒和使用它们的方法。
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公开(公告)号：US20060284074A1
公开(公告)日：2006-12-21
申请号：US11134616
申请日：2005-05-20
Applicant: Huan-Cheng Chang , Joseph Ting
Inventor： Huan-Cheng Chang , Joseph Ting
IPC: H01J49/00
CPC classification number: H01J49/0027
Abstract: A method for identifying a biological organism that includes providing a biological sample corresponding to the biological organism, ionizing the biological sample to produce an ionized sample of the biological sample, performing a mass spectrometry analysis of the ionized sample, and identifying the biological organism in accordance with the mass spectrometry analysis.
Abstract translation: 一种用于识别生物体的方法，包括提供对应于所述生物体的生物样品，电离所述生物样品以产生所述生物样品的离子化样品，对所述离子化样品进行质谱分析，以及根据 通过质谱分析。
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Patent Agency Ranking
公开(公告)号：US11307088B2
公开(公告)日：2022-04-19
申请号：US16698919
申请日：2019-11-27
Applicant: National Central University , Huan-Cheng Chang
Inventor： Min-Chun Pan , Ya-Fen Hsu , Yan-Yang Hsu
Abstract: An optical tomography imaging system includes a signal generator, at least one light emitter, at least one light receiver, a signal processor, and an image processor. The signal generator is configured to generate a periodic signal and a reference signal. The light emitter is configured to be activated by the periodic signal to generate an optical signal passing through an object under test. The light receiver is configured to receive and convert the optical signal passing through the object under test into an electrical signal. The signal processor is configured to generate a comparison signal according to the electrical signal and the reference signal. The image processor is configured to acquire a plurality of disassembled sine waves from the comparison signal and generate a reconstructed image according to the disassembled sine waves.
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公开(公告)号：US11042983B1
公开(公告)日：2021-06-22
申请号：US16884070
申请日：2020-05-27
Inventor： Jang-Zern Tsai , Syu-Jyun Peng , Yu-Wei Chen , Meng-Zong Tsai , Kuo-Wei Wang , Yeh-Lin Kuo
Abstract: The present disclosure provides an operating method of an automatic brain infarction detection system on magnetic resonance imaging (MRI), which includes steps as follows. Images corresponding to different slices of a brain of a subject are received from the MRI machine. The image mask process is performed on first and second images of the images. It is determined whether the cerebellum image intensity and the brain image intensity in the first image are matched. When the cerebellum image intensity and the brain image intensity are not matched, the cerebellar image intensity in the first image is adjusted. The first image is processed through a nonlinear regression to obtain a third image. A neural network identify an infarct region by using the first, second and third images that are cut.
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公开(公告)号：US20210127978A1
公开(公告)日：2021-05-06
申请号：US16693350
申请日：2019-11-24
Applicant: HUAN-CHENG CHANG , National Central University
Inventor： Min-Chun PAN , Pet-Ting LIU , Ya-Fen HSU
IPC: A61B5/00
Abstract: An optical tomography device includes a carrier base, at least one slide rail, at least one sliding assembly, and at least one optical channel member. The carrier base has a through hole. The slide rail is located on the carrier base and extends toward the through hole. The sliding assembly includes a sliding block, a guiding rod, and an elastic component. The sliding block is slidably connected to the slide rail and has a first restriction portion. The guiding rod is slidably connected to the sliding block and has a second restriction portion. The elastic component is configured to be deformed by the first restriction portion and the second restriction portion. The optical channel member is coupled with the guiding rod.
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公开(公告)号：US20200149113A1
公开(公告)日：2020-05-14
申请号：US16460546
申请日：2019-07-02
Applicant: HUAN-CHENG CHANG , National Central University , DELTA ELECTRONICS, INC.
Inventor： Nian-Han MA , Chien-Lung CHEN , Chen-Huan LIN , An-Lun LI , Chiu-Chin HUANG , Chao-Hsiang CHANG
IPC: C12Q1/6886 , C12Q1/6837 , C12Q1/6853
Abstract: A kit for detecting urothelial carcinoma is provided. The kit includes at least one primer or probe for detecting one or more miRNAs, and the one or more miRNAs are selected from the group consisting of miR-19b-1, miR-636, miR-150, miR-155, miR-183, miR-378, miR-210, miR-487, and combinations thereof. A method for detecting urothelial carcinoma is also provided. The method includes detecting the expression level(s) of one or more miRNAs in a sample of a subject, and the one or more miRNAs are selected from the group consisting of miR-19b-1, miR-636, miR-150, miR-155, miR-183, miR-378, miR-210, miR-487, and combinations thereof.
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10.发明授权公开(公告)号：US09466105B2
公开(公告)日：2016-10-11
申请号：US14715565
申请日：2015-05-18
Applicant: National Central University , Huan-Cheng Chang
Inventor： Syu-Jyun Peng , Yu-Wei Chen , Jang-Zern Tsai , Kuo-Wei Wang
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/055 , G01R33/5602 , G01R33/5608 , G01R33/56341 , G06T7/11 , G06T7/174 , G06T2207/10088 , G06T2207/30016
Abstract: A magnetic resonance imaging white matter hyperintensities region recognizing method and system are disclosed herein. The white matter hyperintensities region recognizing method includes receiving and storing a FLAIR MRI image, a spin-lattice relaxation time weighted MRI image, and a diffusion weighted MRI image. Registration and fusion are preformed, and a white matter mask is determined. An intersection image of the FLAIR MRI image and the white matter mask is taken, a first region is determined after normalizing the intersection image, a cerebral infarct region is removed from the first image through the diffusion weighted MRI image, and then a determination is made as to whether to remove a remaining region in order to form a white matter hyperintensities region in the FLAIR MRI image.
Abstract translation: 本文公开了磁共振成像白质高信号区域识别方法和系统。 白质高信号区识别方法包括接收和存储FLAIR MRI图像，自旋晶格弛豫时间加权MRI图像和扩散加权MRI图像。 进行注册和融合，并确定白质掩模。 拍摄FLAIR MRI图像和白质掩模的交叉图像，在对交叉图像进行标准化之后确定第一区域，通过扩散加权MRI图像从第一图像中去除脑梗死区域，然后进行确定 关于是否去除剩余区域以形成FLAIR MRI图像中的白质高信号区域。
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