公开(公告)号：US20180236143A1

公开(公告)日：2018-08-23

申请号：US15899436

申请日：2018-02-20

Applicant: Cook Medical Technologies LLC

Inventor： John Neilan ,  David Murray ,  James Butler

IPC: A61L31/08 ,  B05D3/12 ,  A61L27/30

CPC classification number: A61L31/084 ,  A61F2/90 ,  A61F2/915 ,  A61L27/04 ,  A61L27/303 ,  A61L27/54 ,  A61L31/022 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/18 ,  A61L2420/02 ,  B05D3/12

Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.