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公开(公告)号：US07949383B2
公开(公告)日：2011-05-24
申请号：US11139256
申请日：2005-05-27
IPC分类号： A61B5/05
CPC分类号： G02B27/0018 , G01N21/01 , G02B21/16
摘要： An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. The body further includes a view port enabling viewing of the sample contained in the interior cavity. A door is mounted to the body that is movable between an opened condition, enabling access to the interior cavity through the cavity opening, and a closed condition, positioning a door rear portion substantially adjacent the body front portion to prevent access through the cavity opening. The box assembly further includes a moveable stage disposed in the cavity interior that supports the sample. The moveable stage is adapted to selectively position the sample at a selected one of a plurality of positions relative to the view hole.
摘要翻译： 提供用于捕获样品的图像的成像盒组件。 成像盒组件包括具有用于接收样品的内腔的主体，并且具有限定到空腔中的开口的前部。 身体还包括能够观察包含在内腔中的样品的视野端口。 门被安装到主体上，该打开状态能够在打开状态之间移动，从而能够通过腔体开口进入内腔，并且在闭合状态下定位门后部分，基本上邻近主体前部部分，以防止通过腔体开口进入。 盒组件还包括设置在腔体内部的支撑样品的可移动台。 可移动台适于选择性地将样品定位在相对于视孔的多个位置中的选定的一个位置。
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公开(公告)号：US07813782B2
公开(公告)日：2010-10-12
申请号：US11485923
申请日：2006-07-12
申请人： Michael D. Cable , Bradley W. Rice , David Nilson
发明人： Michael D. Cable , Bradley W. Rice , David Nilson
IPC分类号： A61B5/00
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for handling objects within an imaging system, such as a multi-modal imaging system. An object handling system operates to position an object to be imaged in an interior cavity of a light imaging system, and also moves the object to be imaged between the light imaging system and a second imaging system. The object handling system can include components such as a stage that supports the object, a manipulator configured to move the stage between the interior and exterior of the light imaging system and a light seal configured to interface with a light seal on an exterior wall of the light imaging system.
摘要翻译： 本文描述的本发明提供了用于处理诸如多模式成像系统的成像系统内的物体的系统和方法。 物体处理系统用于将要成像的物体定位在光成像系统的内部空腔中，并且还使待成像对象在光成像系统和第二成像系统之间移动。 物体处理系统可以包括诸如支撑物体的台架的部件，被配置为在光成像系统的内部和外部之间移动台架的机械手以及配置成与所述光成像系统的外壁上的光密封相接合的光密封件 光成像系统。
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公开(公告)号：US07595838B2
公开(公告)日：2009-09-29
申请号：US11485721
申请日：2006-07-12
申请人： David Nilson , Michael D. Cable , Bradley W. Rice
发明人： David Nilson , Michael D. Cable , Bradley W. Rice
IPC分类号： H04N5/225
CPC分类号： G01N21/6456 , A61B5/0059 , A61B2503/40 , G01N21/763
摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.
摘要翻译： 提供了用于拍摄样本图像的系统和方法。 将样品放置在包括可移动台的成像盒中，该移动台允许从成像盒内的各种位置和角度拍摄样品的图像。 图像由相机拍摄并发送到处理器。 可以使用从成像盒内的一个或多个视图获得的结构化光图像来构建样品的结构光表示。
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公开(公告)号：US07581191B2
公开(公告)日：2009-08-25
申请号：US11006294
申请日：2004-12-06
申请人： Bradley W. Rice , Michael D. Cable , Binoy Mirvar , Olivier Coquoz , Chaincy Kuo
发明人： Bradley W. Rice , Michael D. Cable , Binoy Mirvar , Olivier Coquoz , Chaincy Kuo
CPC分类号： A61B5/0059 , A61B5/7435 , A61B2503/40 , G06F3/0481 , G06F3/04815
摘要： The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions pertinent to in vivo light imaging: investigation and control of three-dimensional imaging data and reconstruction algorithms; control of topographic reconstruction algorithms; tomographic spectral imaging and analysis; and comparison of two-dimensional or three-dimensional imaging data obtained at different times.
摘要翻译： 本发明提供一种计算机系统和用户界面，其允许用户容易地查看和分析二维和三维体内图像和成像数据。 用户界面非常适合与体内光成像相关的一个或多个以下动作：三维成像数据和重建算法的调查和控制; 地形重建算法控制; 断层成像和分析; 以及在不同时间获得的二维或三维成像数据的比较。
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公开(公告)号：US07113217B2
公开(公告)日：2006-09-26
申请号：US09905668
申请日：2001-07-13
申请人： David Nilson , Michael D. Cable , Bradley W. Rice
发明人： David Nilson , Michael D. Cable , Bradley W. Rice
CPC分类号： G01N21/6456 , A61B5/0059 , A61B2503/40 , G01N21/763
摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.
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26.发明授权Surface construction using combined photographic and structured light information 有权使用组合的照相和结构光信息进行表面施工公开(公告)号：US08044996B2
公开(公告)日：2011-10-25
申请号：US11429420
申请日：2006-05-04
申请人： Bradley W. Rice , Heng Xu , Chaincy Kuo
发明人： Bradley W. Rice , Heng Xu , Chaincy Kuo
CPC分类号： A61B5/1077 , A61B5/0059 , A61B5/1079 , G01B11/25 , G01N21/532 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6439 , G06T7/521
摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.
摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。
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公开(公告)号：US06754008B1
公开(公告)日：2004-06-22
申请号：US09955005
申请日：2001-09-17
IPC分类号： G02B1502
摘要： Disclosed is an improved lens system for low light applications. This improved low light lens system is designed for any suitable low light application, such as the above described biological imaging application. In one embodiment, a finite conjugate lens system is disclosed. The lens system includes, in order from a camera side to an object side, a first lens group and a second lens group. The first and second lens groups are adapted so that when light is passed from the object side to the image side, a substantially sized region of collimated light is formed between the first and second lens group. Preferably, the first and second lens groups are adapted to demagnify an object at the object side.
摘要翻译： 公开了一种用于低光应用的改进的透镜系统。 这种改进的低光透镜系统被设计用于任何合适的低光应用，例如上述生物成像应用。 在一个实施例中，公开了一种有限共轭透镜系统。 透镜系统从照相机侧到物体侧依次包括第一透镜组和第二透镜组。 第一透镜组和第二透镜组被适配成使得当光从物体侧传送到像侧时，在第一和第二透镜组之间形成基本尺寸的准直光的区域。 优选地，第一透镜组和第二透镜组适于在物体侧使物体缩小。
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公开(公告)号：US10335038B2
公开(公告)日：2019-07-02
申请号：US11844920
申请日：2007-08-24
申请人： Heng Xu , Bradley W. Rice
发明人： Heng Xu , Bradley W. Rice
摘要： Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.
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公开(公告)号：US20120150026A1
公开(公告)日：2012-06-14
申请号：US13397518
申请日：2012-02-15
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , G01N21/4795 , G01N21/6428
摘要： A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.
摘要翻译： 公开了一种调查受试者中发光源的位置和尺寸的方法。 在实施该方法时，首先通过用光电检测器件从第一个角度测量光源（i）来源于发光源，（ii）穿过受试者的混浊生物组织，以及 （iii）从对象的感兴趣的第一表面区域发射。 光强度曲线与基于参数的生物光子函数匹配，以估计诸如深度和大小的函数参数。 使用除第一测量光强度分布之外的数据来精确地确定如此确定的参数，以获得对象中源的近似深度和大小。 还公开了一种用于执行该方法的装置。
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30.发明授权Method and apparatus for determining target depth, brightness and size within a body region 有权用于确定身体区域内的目标深度，亮度和尺寸的方法和装置公开(公告)号：US07764986B2
公开(公告)日：2010-07-27
申请号：US11829930
申请日：2007-07-29
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , G01N21/4795 , G01N21/6428
摘要： A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.
摘要翻译： 公开了一种调查受试者中发光源的位置和尺寸的方法。 在实施该方法时，首先通过用光电检测器件从第一个角度测量光源（i）来源于发光源，（ii）穿过受试者的混浊生物组织，以及 （iii）从对象的感兴趣的第一表面区域发射。 光强度曲线与基于参数的生物光子函数匹配，以估计诸如深度和大小的函数参数。 使用除第一测量光强度分布之外的数据来精确地确定如此确定的参数，以获得对象中源的近似深度和大小。 还公开了一种用于执行该方法的装置。
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