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公开(公告)号：US07581191B2
公开(公告)日：2009-08-25
申请号：US11006294
申请日：2004-12-06
申请人： Bradley W. Rice , Michael D. Cable , Binoy Mirvar , Olivier Coquoz , Chaincy Kuo
发明人： Bradley W. Rice , Michael D. Cable , Binoy Mirvar , Olivier Coquoz , Chaincy Kuo
CPC分类号： A61B5/0059 , A61B5/7435 , A61B2503/40 , G06F3/0481 , G06F3/04815
摘要： The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions pertinent to in vivo light imaging: investigation and control of three-dimensional imaging data and reconstruction algorithms; control of topographic reconstruction algorithms; tomographic spectral imaging and analysis; and comparison of two-dimensional or three-dimensional imaging data obtained at different times.
摘要翻译： 本发明提供一种计算机系统和用户界面，其允许用户容易地查看和分析二维和三维体内图像和成像数据。 用户界面非常适合与体内光成像相关的一个或多个以下动作：三维成像数据和重建算法的调查和控制; 地形重建算法控制; 断层成像和分析; 以及在不同时间获得的二维或三维成像数据的比较。
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公开(公告)号：US07555334B2
公开(公告)日：2009-06-30
申请号：US10969230
申请日：2004-10-19
CPC分类号： G01N21/6456 , G01J1/42 , G01N21/763 , G01N2021/6439
摘要： Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a substantial portion of light emitted from the animal from escaping the chamber when the chamber is closed and the animal is inside the chamber and a light monitoring device for collecting light from different portions of the animal when the animal is inside the closed chamber. The light monitoring device is arranged to collect light over substantially the entire surface area of the body and head of the animal, and the light monitoring device generates a quantified value based on the light collected from the animal. The animal does not have to be under anesthesia.
摘要翻译： 公开了用于收集从动物发射的光的方法和装置，其中发光报告物已经注射到动物中。 所述装置包括用于接收动物的腔室，其中，所述腔室是不透光的，以防止当所述腔室关闭并且所述动物在所述腔室内时从所述动物发射的大部分光逸出所述腔室;以及用于收集光的光监测装置 当动物在封闭室内时，来自动物的不同部分。 光监视装置被布置成在动物的身体和头部的基本上整个表面区域上收集光，并且光监视装置基于从动物收集的光产生量化值。 动物不必在麻醉下。
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3.发明授权Surface construction using combined photographic and structured light information 有权使用组合的照相和结构光信息进行表面施工公开(公告)号：US08044996B2
公开(公告)日：2011-10-25
申请号：US11429420
申请日：2006-05-04
申请人： Bradley W. Rice , Heng Xu , Chaincy Kuo
发明人： Bradley W. Rice , Heng Xu , Chaincy Kuo
CPC分类号： A61B5/1077 , A61B5/0059 , A61B5/1079 , G01B11/25 , G01N21/532 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6439 , G06T7/521
摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.
摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。
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公开(公告)号：US07599731B2
公开(公告)日：2009-10-06
申请号：US11733358
申请日：2007-04-10
申请人： Bradley W. Rice , Chaincy Kuo , Daniel G. Stearns , Heng Xu
发明人： Bradley W. Rice , Chaincy Kuo , Daniel G. Stearns , Heng Xu
CPC分类号： A61B5/0073 , G01N21/49 , G01N2021/1787 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439
摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.
摘要翻译： 本文描述了用于获得样品（例如哺乳动物）内荧光探针分布的三维（3D）表示的系统和方法。 使用a）来自一个或多个图像的荧光发射数据，b）哺乳动物的表面表示，以及c）计算机实现的光子传播模型，所述系统和方法在哺乳动物中产生荧光探针分布的3D表示。 分布可以指示 - 哺乳动物中一种或多种荧光探针的位置，大小和/或亮度或浓度。
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公开(公告)号：US07555332B2
公开(公告)日：2009-06-30
申请号：US11829927
申请日：2007-07-29
申请人： Bradley W. Rice , Chaincy Kuo , Daniel G. Stearns , Heng Xu
发明人： Bradley W. Rice , Chaincy Kuo , Daniel G. Stearns , Heng Xu
CPC分类号： A61B5/0073 , G01N21/49 , G01N2021/1787 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439
摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.
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公开(公告)号：US08279334B2
公开(公告)日：2012-10-02
申请号：US11871062
申请日：2007-10-11
申请人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
发明人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
CPC分类号： G01B11/2513 , A61B5/0059 , A61B5/0064 , A61B5/107 , A61B5/6888 , A61B2503/40 , G01B11/2518 , G01N21/6456 , G01N21/763 , G06T7/521 , H04N13/254
摘要： The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.
摘要翻译： 本发明将结构化光源集成到成像系统中，用于重建被成像物体的表面形貌。 结构化光源包括用于从一角度将一组线传送到物体上的机构。 当它们遇到具有有限高度的对象（例如鼠标）时，线相对于舞台移位或相移。 该相移提供了对象的结构光信息。 相机拍摄结构光信息。 使用采用结构光分析的软件，根据线的相移确定物体的表面形貌数据。
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公开(公告)号：US07589786B2
公开(公告)日：2009-09-15
申请号：US11486239
申请日：2006-07-12
申请人： David Nilson , Michael D. Cable , Bradley W. Rice
发明人： David Nilson , Michael D. Cable , Bradley W. Rice
CPC分类号： G01N21/6456 , A61B5/0059 , A61B2503/40 , G01N21/763
摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.
摘要翻译： 提供了用于拍摄样本图像的系统和方法。 将样品放置在包括可移动台的成像盒中，该移动台允许从成像盒内的各种位置和角度拍摄样品的图像。 图像由相机拍摄并发送到处理器。 可以使用从成像盒内的一个或多个视图获得的结构化光图像来构建样品的结构光表示。
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公开(公告)号：US20110090316A1
公开(公告)日：2011-04-21
申请号：US12947794
申请日：2010-11-16
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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公开(公告)号：US07881773B2
公开(公告)日：2011-02-01
申请号：US11485920
申请日：2006-07-12
申请人： Michael D. Cable , Bradley W. Rice , David Nilson
发明人： Michael D. Cable , Bradley W. Rice , David Nilson
IPC分类号： A61B5/00
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.
摘要翻译： 本文描述的本发明提供了用于具有光和第二形式的成像的多模式成像的系统和方法。 光成像涉及捕获来自发光物体的低强度光。 相机获得从被摄体的表面发射的光的二维空间分布。 由与摄像机通信的计算机操作的软件然后可以将二维空间分布数据从一个或多个图像转换为三维空间表示。 第二成像模式可以包括补充光成像的任何成像技术。 实例包括磁共振成像（MRI）和计算机地形（CT）。 物体处理系统将要成像的对象移动到光成像系统和第二成像系统之间，并且被配置为与每个系统接口。
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公开(公告)号：US07190991B2
公开(公告)日：2007-03-13
申请号：US10881707
申请日：2004-06-29
申请人： Michael D. Cable , Bradley W. Rice , David Nilson
发明人： Michael D. Cable , Bradley W. Rice , David Nilson
IPC分类号： A61B5/05
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.
摘要翻译： 本文描述的本发明提供了用于具有光和第二形式的成像的多模式成像的系统和方法。 光成像涉及捕获来自发光物体的低强度光。 相机获得从被摄体的表面发射的光的二维空间分布。 由与摄像机通信的计算机操作的软件然后可以将二维空间分布数据从一个或多个图像转换为三维空间表示。 第二成像模式可以包括补充光成像的任何成像技术。 实例包括磁共振成像（MRI）和计算机地形（CT）。 物体处理系统将要成像的对象移动到光成像系统和第二成像系统之间，并且被配置为与每个系统接口。
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