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公开(公告)号：US10772851B2
公开(公告)日：2020-09-15
申请号：US15886469
申请日：2018-02-01
申请人： Aaron Kurt Neumann , Harry Craig Pappas , Matthew Graus , David G. Whitten , Kirk S. Schanze , Rina Sylejmani
发明人： Aaron Kurt Neumann , Harry Craig Pappas , Matthew Graus , David G. Whitten , Kirk S. Schanze , Rina Sylejmani
IPC分类号： A61K31/14 , A61K31/75 , A61K31/795 , A61P31/10
摘要： Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a β-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the β-glucan to increase immunogenicity of the fungus.
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22.发明申请公开(公告)号：US20170023554A1
公开(公告)日：2017-01-26
申请号：US15125896
申请日：2015-03-13
申请人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
发明人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
摘要： Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
摘要翻译： 各种实施方案涉及作为生物活性和检测剂的对亚苯基亚乙炔化合物。 在各种实施方案中，本发明提供诱导微生物孢子发芽的方法，包括使微生物孢子与对亚苯基亚乙炔基化合物接触。 在各种实施方案中，本发明提供了检测酶的方法，蛋白质分析方法或检测化学试剂的方法，包括将对亚苯基亚乙烯基化合物引入到包含酶底物的组合物中，并分析荧光 的对亚苯基亚乙炔基化合物。 各种实施方案提供包括对亚苯基亚乙炔化合物和酶底物的传感器。
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公开(公告)号：US08618009B2
公开(公告)日：2013-12-31
申请号：US13128571
申请日：2009-11-09
CPC分类号： A01N25/28 , A01N25/00 , A01N25/10 , A01N25/34 , A01N43/90 , A61L2/23 , Y10S977/712 , Y10S977/903 , Y10T428/2982 , A01N41/04 , A01N2300/00
摘要： Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.
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公开(公告)号：US20080044805A1
公开(公告)日：2008-02-21
申请号：US11842710
申请日：2007-08-21
IPC分类号： G01N33/00
CPC分类号： G01N33/48714
摘要： The present disclosure provides rapid, simple, robust and sensitive label and label-free assays for use in drug discovery, bioagent detection and medical diagnostics as well as means for reading such assays. The assays disclosed in the present disclosure use the formation, disruption and destruction of self-assembling fluorescent dye:biopolymer complexes to indicate the presence or absence of an analyte of interest. Such assays are suitable for high throughput screening and can achieve high sensitivity due to the enhanced fluorescence and changes of absorption spectra of certain dyes, particularly cyanine dyes, when they bind to specific biopolymers.
摘要翻译： 本公开内容提供用于药物发现，生物代谢检测和医学诊断的快速，简单，稳健且灵敏的标记和无标记测定，以及用于阅读这些测定的手段。 本公开中公开的测定法使用自组装荧光染料：生物聚合物复合物的形成，破坏和破坏，以指示感兴趣的分析物的存在或不存在。 这种测定法适用于高通量筛选，并且由于当某些染料，特别是花青染料结合特定的生物聚合物时，增强的荧光和吸收光谱的变化，可以实现高灵敏度。
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公开(公告)号：US06743640B2
公开(公告)日：2004-06-01
申请号：US09850074
申请日：2001-05-08
IPC分类号： G01N33543
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/542 , G01N2021/6432 , G01N2021/6439 , Y10S436/808
摘要： A chemical composition including a moiety comprising a quencher (Q), a tethering element (T), and a ligand (L) that associates with and quenches a fluorescent polymer is disclosed. When an analyte sample is introduced, the ligand (L) binds to a target biological agent if it is present, thereby causing the QTL molecule to separate from the fluorescent polymer resulting in an increase in detected fluorescence. The same chemistry is advantageously employed in a competitive assay. An electric field can also be applied to separate the QTL molecule from the fluorescent polymer. A method for detecting targets for these methods are also disclosed.
摘要翻译： 公开了一种化学组合物，其包含与猝灭剂（Q），束缚元件（T）和与荧光聚合物缔合并猝灭的配体（L）的部分。 当引入分析物样品时，配体（L）如果存在则与目标生物试剂结合，从而使QTL分子与荧光聚合物分离，导致检测到的荧光增加。 在竞争性测定中有利地使用相同的化学物质。 也可以应用电场以将QTL分子与荧光聚合物分离。 还公开了一种用于检测这些方法的靶的方法。
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26.发明申请公开(公告)号：US20150132184A1
公开(公告)日：2015-05-14
申请号：US14533612
申请日：2014-11-05
申请人： David G. Whitten , Eric H. Hill , Harry C. Pappas
发明人： David G. Whitten , Eric H. Hill , Harry C. Pappas
摘要： The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
摘要翻译： 本发明涉及包含带电荷的低聚 - 亚苯基亚乙烯基单线态 - 氧气敏化剂和带相反电荷的表面活性剂的组合物，相对于不含相反电荷的表面活性剂的低聚 - 亚苯基亚乙炔的相当浓度，其显示出增强的杀生物活性。 在阳离子表面活性剂如TTAB存在下，用阴离子低聚亚苯基亚乙炔基和阴离子表面活性剂如SDS存在下用阳离子低聚亚苯基亚乙炔基观察到杀生物活性的增强。
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公开(公告)号：US06979543B2
公开(公告)日：2005-12-27
申请号：US10412568
申请日：2003-04-10
IPC分类号： C07C319/14 , C07C323/12 , G01N33/543 , C12Q1/68
CPC分类号： G01N33/54373 , C07B2200/05 , C07C319/14 , G01N33/5438 , G01N33/54386 , Y10S435/808 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/808 , Y10S436/823 , Y10S530/811 , Y10S530/812 , C07C323/12
摘要： A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.
摘要翻译： 提供了一种传感器，其包括能够从发光和导电性组中具有可改变的可测量性质的聚合物，所述聚合物具有识别元件，束缚元件和结合到其上的改变属性的元件的中间组合，并且能够改变 可测量的性质，适于在暴露于具有与识别元件结合的亲和力的试剂之后随后与聚合物分离的中间体组合，因此中间体组合与聚合物的分离导致可改变的可测量性质的可检测变化， 检测可变的可测量性质中的所述可检测变化。
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公开(公告)号：US06589731B1
公开(公告)日：2003-07-08
申请号：US09565589
申请日：2000-05-04
IPC分类号： G01N3353
CPC分类号： G01N33/5438 , G01N33/542 , G01N33/54373 , G01N33/54386 , Y10S435/808 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/808 , Y10S436/823
摘要： A sensor element is provided including a polymer exhibiting a measurable property from the group of luminescence and electrical conductivity, the polymer being complexed with a unit including a recognition element, a tethering element and a property-altering element bound thereto so as to alter the measurable property, the unit being susceptible of subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the unit from the polymer results in a detectable change in the measurable property.
摘要翻译： 提供了一种传感器元件，其包括从发光和导电性组中显示可测量性质的聚合物，所述聚合物与包括识别元件，系链元件和结合到其上的改变属性的单元复合，以便改变可测量的 性质，该单元易于暴露于具有与识别元件结合的亲和性的试剂后随后与聚合物分离，因此单元与聚合物的分离导致可测量性质的可检测变化。
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