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公开(公告)号：US20070167484A1
公开(公告)日：2007-07-19
申请号：US11726339
申请日：2007-03-21
Applicant: David Goldstein , Julie Lim
Inventor： David Goldstein , Julie Lim
IPC: A61K31/4745 , C07D471/02
CPC classification number: C07D471/04
Abstract: The present invention provides compounds of the Formula I: wherein R1 is allyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
Abstract translation: 本发明提供了式I的化合物：其中R 1是烯丙基，环烷基，环烷基烷基或-CH 2 - 烯基，X 1， 是O，NH，N（烷基），S或-C（-O），Z是N或CH; R 2和R 3如本文所定义，包含其的药物组合物及其使用方法。
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公开(公告)号：US20070167471A1
公开(公告)日：2007-07-19
申请号：US11728644
申请日：2007-03-27
Applicant: James Dunn , David Goldstein , Christoph Stahl , Teresa Trejo-Martin
Inventor： James Dunn , David Goldstein , Christoph Stahl , Teresa Trejo-Martin
IPC: A61K31/517 , C07D403/02 , C07D239/94
CPC classification number: C07D239/84 , C07D401/12 , C07D405/12
Abstract: Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and R7 are optional substituents, and Q is a non-aromatic moiety as defined in the specification.
Abstract translation: 具有式（I）的化合物可用作p38激酶抑制剂，其中R 4和R 5是氢，卤素，氰基，卤代烷基或卤代烷氧基，但不是 氢; R 6和R 7是任选的取代基，Q是说明书中定义的非芳族部分。
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公开(公告)号：US07083420B2
公开(公告)日：2006-08-01
申请号：US10775830
申请日：2004-02-09
Applicant: Michael C. Wood , Alice Chen , David Goldstein , Mark Flowers , Joseph B. Miller, III , Michelle Fitts , Curtis Cole , Rick Adolf , Antonia Kohl , Carol Thies
Inventor： Michael C. Wood , Alice Chen , David Goldstein , Mark Flowers , Joseph B. Miller, III , Michelle Fitts , Curtis Cole , Rick Adolf , Antonia Kohl , Carol Thies
IPC: G09B7/00
CPC classification number: A63F13/92 , A63F13/08 , A63F13/2145 , A63F13/95 , A63F2300/1075 , A63F2300/204 , A63F2300/206 , A63F2300/302 , G09B5/06 , G09B19/00 , H01M2/1022
Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.
Abstract translation: 提供了一种交互式手持设备。 该装置包括壳体，壳体上的显示屏，电子位置定位系统，用于在显示屏幕上选择图像的触控笔，壳体上的方向控制板和存储器件。 电子位置定位系统包括能够确定显示屏幕的选定区域的位置的处理器。 存储装置包括用于教育游戏的计算机代码，并且可操作地耦合到处理器。
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公开(公告)号：US20050215595A1
公开(公告)日：2005-09-29
申请号：US11065979
申请日：2005-02-25
Applicant: Nidhi Arora , Tobias Gabriel , David Goldstein , Teresa Trejo-Martin
Inventor： Nidhi Arora , Tobias Gabriel , David Goldstein , Teresa Trejo-Martin
IPC: C07D231/56 , A61K31/4439 , A61K31/416 , C07D43/02
CPC classification number: C07D231/56
Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R1, R2 and R3 are those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
Abstract translation: 式I化合物或其药学上可接受的盐，溶剂化物或前体药物，其中m，k，B，R 1，R 2和R 3， SUP>是本文定义的那些，以及包含它们的组合物。 还提供了制备式I化合物的方法，并将其用于治疗患者中p38介导的病症。
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公开(公告)号：US06561461B2
公开(公告)日：2003-05-13
申请号：US09925206
申请日：2001-08-09
Applicant: David Goldstein , Scott A. McDermott , Paul Gloyer , Richard Fleeter
Inventor： David Goldstein , Scott A. McDermott , Paul Gloyer , Richard Fleeter
IPC: B64G122
CPC classification number: B64G1/10 , B64G1/007 , B64G1/1085 , B64G1/222 , B64G1/24 , B64G1/242 , B64G1/425 , B64G1/428 , B64G1/50 , B64G1/641 , B64G2001/224
Abstract: An orbit-transfer vehicle provides the navigation, propulsion, and control systems required to transport a payload satellite from a geosynchronous-transfer orbit (GTO) to a predetermined low-earth orbit (LEO). Upon entering low-earth orbit, the payload satellite is deployed from the orbit-transfer vehicle. To reduce the cost and complexity of the payload satellite, the orbit-transfer vehicle is configured to provide common functional services, such as communications and power regulation, to the payload satellite during the transport, and/or after deployment. To reduce the fuel requirements for this deployment via the orbit-transfer vehicle, a preferred embodiment includes aerobraking to bring the satellite into a low-earth orbit. In a preferred embodiment of this method of deployment, the provider of the orbit-transfer vehicle identifies and secures available excess capacity on launch vehicles, and allocates the excess capacity to the satellites requiring deployment, thereby providing a deployment means that is virtually transparent to the purchaser of this deployment service.
Abstract translation: 轨道转移车辆提供将有效载荷从地球同步转移轨道（GTO）运输到预定的低地球轨道（LEO）所需的导航，推进和控制系统。 进入低地球轨道后，载具卫星从轨道转运车辆部署。 为了降低有效载荷卫星的成本和复杂性，轨道转移车辆被配置为在运输期间和/或部署之后向有效载荷卫星提供诸如通信和功率调节之类的共同功能服务。 为了减少通过轨道转运车辆的这种部署的燃料需求，优选实施例包括使卫星进入低地球轨道的航空制动。 在这种部署方法的优选实施例中，轨道转移车辆的提供者识别并确保运载火箭上的可用剩余容量，并且将剩余容量分配给需要部署的卫星，由此提供对于 此部署服务的购买者。
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Patent Agency Ranking
公开(公告)号：US5408932A
公开(公告)日：1995-04-25
申请号：US301505
申请日：1994-09-07
Applicant: Philip W. Hesse , David Goldstein
Inventor： Philip W. Hesse , David Goldstein
CPC classification number: F42B12/74
Abstract: An elongated rod made of a shape memory alloy composition having selected eudoelastic properties, is deformed into a dimensionally compact coil for packaged storage under stress maintained by physical constraint. Upon selective removal of the constraint allowing shape recovery, a substantial increase in axial length of the rod occurs in order to improve its performance in various installations, including long rod penetrating projectiles.
Abstract translation: 由具有选择的假弹性特性的形状记忆合金组合物制成的细长杆变形成尺寸紧凑的线圈，用于通过物理约束保持的应力下的包装储存。 在选择性地去除允许形状恢复的约束时，出现杆的轴向长度的显着增加，以便改善其在各种设备中的性能，包括长杆穿透射弹。
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公开(公告)号：US4722825A
公开(公告)日：1988-02-02
申请号：US68395
申请日：1987-07-01
Applicant: David Goldstein
Inventor： David Goldstein
CPC classification number: C04B37/021 , B22F3/1225 , B22F3/15 , C04B35/64 , C04B35/6455 , C22C1/0433 , F41A21/02 , C04B2235/6581 , C04B2237/343 , C04B2237/36 , C04B2237/365 , C04B2237/368 , C04B2237/403 , C04B2237/405 , C04B2237/406 , C04B2237/66 , C04B2237/765 , C04B2237/84
Abstract: A method of producing a metal/ceramic composite structure in which an uncolidated metal or metal alloy powder is loaded into a sealable glass mold comprising a hollow ceramic sleeve and a sealable outer glass envelope surrounding the ceramic sleeve and forming with the outer wall of the ceramic sleeve a sealable chamber for the metal or metal alloy powder, wherein the glass is a type which becomes plastic when heated. The air in the mold is removed under vacuum and the mold is sealed and placed into a free flowing refractory powder in a crucible and consolidated by sintering under atmospheric pressure (CAP.RTM. process). Removal of the glass envelope leaves a composite article having a consolidated metal or metal alloy layer surrounding and placing a hollow ceramic liner (sleeve) under both radial and axial compression. A ceramic-line metal gun barrel insert can be produced by using a ceramic sleeve with rifling on its inner surface.
Abstract translation: 一种制造金属/陶瓷复合结构体的方法，其中将未固结的金属或金属合金粉末装载到可密封的玻璃模具中，该可密封玻璃模具包括中空陶瓷套筒和围绕陶瓷套筒的可密封的外部玻璃封套，并与陶瓷的外壁形成 套住用于金属或金属合金粉末的可密封室，其中玻璃是加热时变成塑料的类型。 在真空中除去模具中的空气，并将模具密封并置于坩埚中的自由流动的耐火粉末中，并通过在大气压（CAP TM工艺）下烧结而固化。 去除玻璃封套留下具有固结的金属或金属合金层的复合制品，围绕并在径向和轴向压缩下放置中空陶瓷衬套（套筒）。 可以通过在其内表面上使用具有膛线的陶瓷套筒来制造陶瓷线金属枪管插入件。
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公开(公告)号：US4702884A
公开(公告)日：1987-10-27
申请号：US887165
申请日：1986-07-03
Applicant: David Goldstein
Inventor： David Goldstein
CPC classification number: B22F3/1225 , B22F3/10 , B22F7/06 , C03C27/02 , Y10T428/12056 , Y10T428/1317 , Y10T428/30
Abstract: A method of producing a glass-lined metal pipe in which an unconsolidated tal or metal alloy powder is loaded into a sealable glass mold comprising a graphite core, a glass sleeve slipped over the graphite core with a sliding fit, a sealable outer glass envelope surrounding the graphite core and glass sleeve forming with them a sealable chamber for the metal or metal alloy powder, wherein the glass is a type which becomes plastic when heated. The air in the mold is removed under vacuum and the mold is sealed and placed into a free flowing refractory powder in a crucible and consolidated by sintering under atmospheric pressure (CAP.RTM. process). Removal of the glass envelope and the graphite core produces a glass-lined pipe in which the glass liner is slightly fused into and is under compressive force from the surrounding metal pipe.
Abstract translation: 一种制造玻璃衬里金属管的方法，其中将未固结的金属或金属合金粉末装载到可密封的玻璃模具中，该可密封玻璃模具包括石墨芯，滑动配合地滑过石墨芯上的玻璃套管，围绕 石墨芯和玻璃套与它们形成用于金属或金属合金粉末的可密封室，其中玻璃是加热时变成塑料的类型。 在真空中除去模具中的空气，并将模具密封并置于坩埚中的自由流动的耐火粉末中，并通过在大气压（CAP TM工艺）下烧结而固化。 玻璃管和石墨芯的移除产生玻璃衬里管，其中玻璃衬里稍微熔化并且处于来自周围金属管的压力下。
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29.发明授权Method of modifying the transition temperature range of TiNi base shape memory alloys 失效修改TiNi基形状记忆合金的转变温度范围的方法
公开(公告)号：US4283233A
公开(公告)日：1981-08-11
申请号：US128326
申请日：1980-03-07
Applicant: David Goldstein , Richard E. Jones , Robert S. Sery
Inventor： David Goldstein , Richard E. Jones , Robert S. Sery
CPC classification number: C22F1/006
Abstract: A method of changing the shape change transition temperature range (TTR) of an object made from a nickel-titanium based shape change memory alloy by selection of the final annealing temperature.
Abstract translation: 通过选择最终退火温度来改变由镍钛基形状变化记忆合金制成的物体的形状变化转变温度范围（TTR）的方法。
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公开(公告)号：US4185079A
公开(公告)日：1980-01-22
申请号：US913785
申请日：1978-06-08
Applicant: Theodore F. Munday , David Goldstein , John Walden
Inventor： Theodore F. Munday , David Goldstein , John Walden
Abstract: A method for removing small concentrations of phosphine contained in a carbon monoxide gas mixture by preferentially oxidizing the phosphine, in which the phosphine is oxidized with air at a temperature of from 500.degree. C. to 800.degree. C. to form phosphorus pentoxide, which is recovered from the gas mixture preferably as phosphoric acid.
Abstract translation: 通过优先氧化磷化氢来除去一氧化碳气体混合物中所含的小浓度磷化氢的方法，其中磷化氢在空气中在500〜800℃下氧化形成五氧化二磷 从气体混合物中优选以磷酸的形式回收。
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