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1.发明申请公开(公告)号：US20140081409A1
公开(公告)日：2014-03-20
申请号：US13832424
申请日：2013-03-15
申请人： PETER J JAMES , RICHARD E JONES , BENJAMIN J SORDELET , TIMOTHY G VENDRELY , STEPHANIE M WAINSCOTT
发明人： PETER J JAMES , RICHARD E JONES , BENJAMIN J SORDELET , TIMOTHY G VENDRELY , STEPHANIE M WAINSCOTT
IPC分类号： A61F2/38
CPC分类号： A61F2/3886 , A61F2/30734 , A61F2002/30334 , A61F2002/30344 , A61F2002/30604 , A61F2002/30616 , A61F2002/30738
摘要： A modular knee prosthesis system includes a femoral component having a stem and a sleeve. The system is modular, and provides the surgeon with the option of distally offsetting the joint line by controlling the relative axial positions of the stem and the sleeve. Alternative options include providing sleeves with tapered bores of different diameters, providing a shim to be placed between the sleeve and the stem and providing the stems as adapters having different diameters.
摘要翻译： 模块化膝关节假体系统包括具有杆和套筒的股骨部件。 该系统是模块化的，并且通过控制杆和套筒的相对轴向位置为外科医生提供远端抵消关节线的选项。 替代方案包括为不同直径的锥形孔提供套筒，提供垫片放置在套筒和杆之间，并将杆作为具有不同直径的适配器。
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公开(公告)号：US06699844B2
公开(公告)日：2004-03-02
申请号：US10308136
申请日：2002-12-03
申请人： Richard E. Jones , Ning Y. Yu
发明人： Richard E. Jones , Ning Y. Yu
IPC分类号： A61K31505
CPC分类号： A61K31/70
摘要： Methods of treating cancer by administration of FMdC followed by administration of a platinate are disclosed.
摘要翻译： 公开了通过施用FMdC治疗癌症的方法，然后施用铂酸盐。
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公开(公告)号：US6077545A
公开(公告)日：2000-06-20
申请号：US550086
申请日：1995-10-30
IPC分类号： A61K47/36 , A61K31/00 , A61K31/135 , A61K31/137 , A61K33/24 , A61K47/26 , A61K47/38 , A61K47/42 , A61P35/00
CPC分类号： A61K47/26 , A61K33/24 , A61K47/38 , A61K47/42 , A61K9/0019
摘要： An improved diluent for the preparation of cisplatin suspensions from a lyophilized powder is provided. The diluent contains a pharmaceutically acceptable nonionic surfactant, which improves the accuracy and homogeneity of the therapeutic formulation. The suspension may be used directly, or may be used in preparing gel formulations for direct injection into a neoplastic lesion or surrounding tissue.
摘要翻译： 提供了用于从冻干粉末制备顺铂悬浮液的改进的稀释剂。 稀释剂含有药学上可接受的非离子表面活性剂，其改善了治疗制剂的准确性和均匀性。 悬浮液可以直接使用，或者可以用于制备用于直接注射到肿瘤损伤或周围组织中的凝胶制剂。
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公开(公告)号：USD402078S
公开(公告)日：1998-12-01
申请号：US66830
申请日：1997-02-25
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公开(公告)号：US5750146A
公开(公告)日：1998-05-12
申请号：US431084
申请日：1995-04-28
申请人： Richard E. Jones , Mike T. Li
发明人： Richard E. Jones , Mike T. Li
IPC分类号： A61K9/107 , A61K9/00 , A61K31/135 , A61K31/505 , A61K45/00 , A61K47/42 , A61P9/00 , A61P35/00 , A61K9/10
CPC分类号： A61K9/0024 , A61K47/42
摘要： Disclosed are translucent proteinaceous compositions comprising collagen and an effective amount of a compatible cytotoxic drug which compositions are characterized by having a single collagen transition temperature of less than about 45.degree. C. Such compositions possess enhanced retention of the cytotoxic drug at the site of injection and are optically translucent.
摘要翻译： 公开了包含胶原和有效量的相容的细胞毒性药物的半透明蛋白质组合物，该组合物的特征在于具有小于约45℃的单一胶原转变温度。这些组合物具有增强的注射部位的细胞毒性药物的保留性， 是光学半透明的。
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6.发明授权Methods and compositions for the treatment of a host with a cellular proliferative disease 失效用于治疗具有细胞增殖性疾病的宿主的方法和组合物
公开(公告)号：US5573781A
公开(公告)日：1996-11-12
申请号：US365664
申请日：1994-12-29
IPC分类号： A61K9/08 , A61K9/00 , A61K31/135 , A61K31/28 , A61K31/335 , A61K31/34 , A61K31/40 , A61K31/505 , A61K31/70 , A61K33/24 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/44 , A61P3/06 , A61P35/00 , A61P43/00 , A61K9/14 , A61K9/50 , A61K37/00
CPC分类号： A61K33/24 , A61K47/10 , A61K47/44 , A61K9/0019 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/943
摘要： Methods and compositions are provided for the treatment of a host with a cellular proliferative disease, particularly a neoplasia. In the subject methods, a pharmaceutically acceptable, substantially anhydrous, injectable semi-solid composition which acts as a depot for a cytostatic agent, is administered to a lesion of the disease, particularly intralesionally. The subject compositions comprise a water immiscible, fatty acid ester matrix and a cytostatic agent.
摘要翻译： 提供了用于治疗具有细胞增殖性疾病，特别是瘤形成的宿主的方法和组合物。 在本发明的方法中，将药用可接受的，基本上无水的可注射的半固体组合物作为细胞生长抑制剂的贮库施用于疾病的病变，特别是病灶内。 主题组合物包含与水不混溶的脂肪酸酯基质和细胞生长抑制剂。
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公开(公告)号：US5151265A
公开(公告)日：1992-09-29
申请号：US514392
申请日：1990-04-25
CPC分类号： A61K47/12 , A61K38/217 , A61K47/26 , A61K9/0019
摘要： A liquid pharmaceutical composition comprising an effective amount of non-lyophilized gamma-interferon. The liquid pharmaceutical composition which additionally includes a buffer capable of maintaining the pH of the liquid composition within the range of 4.0 to 6.0, a stabilizing agent and a non-ionic detergent.
摘要翻译： 一种液体药物组合物，其包含有效量的非冻干γ-干扰素。 液体药物组合物另外包括能够将液体组合物的pH值保持在4.0-6.0范围内的缓冲剂，稳定剂和非离子型洗涤剂。
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公开(公告)号：US4921657A
公开(公告)日：1990-05-01
申请号：US120108
申请日：1987-11-13
IPC分类号： C01B21/068 , C01B21/082 , C04B35/56 , C04B35/571 , C04B35/575 , C04B35/589 , C04B35/593 , D01F9/10
CPC分类号： D01F9/10 , C04B35/571 , C04B35/5755 , C04B35/589 , C04B35/5935
摘要： The elastic modulus and density of an amorphous, ceramic article derived from a resinous organosilicon polymer and having a composition consisting essentially of silicon, nitrogen and/or carbon are increased while substantially maintaining or improving tensile strength by heat treating the ceramic article at an elevated temperature under superatmospheric nitrogen pressure to increase its density while avoiding crystallization. During heat treatment, at least some of the conditions of time, temperature, heating rate, cooling rate, pressure and atmosphere are controlled to minimize erosion of the article which could otherwise occur due to the loss to the surrounding atmosphere, as a gas or gaseous component, of at least one of nitrogen, silicon and carbon. The heat treated, ceramic article is amorphous and non-crystalline and has a density substantially greater than 2.5 g/cc together with desirable values of tensile strength and elastic modulus.
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公开(公告)号：US4715361A
公开(公告)日：1987-12-29
申请号：US908941
申请日：1986-09-16
IPC分类号： A61H1/02
CPC分类号： A61H1/0255
摘要： Apparatus for passively exercising the human extremities includes an elongate track (16) comprising a tubular housing (46) having a slot formed in the bottom thereof. A lead screw (62) is longitudinally disposed in the housing and a carriage (26) is threadably engaged with the lead screw (62). The carriage (26) is connected to the extremity to be exercised, so that upon movement of the carriage (26) back and forth along the elongated track (16) the extremity is moved through a pre-determined range of motion. Stop members (28) are positionable on the housing in the path of movement of the carriage (26). Engagement of the carriage (26) with the stop member (28) effects longitudinal shifting of the lead screw (62). Longitudinal shifting of the lead screw (62) actuates switches (110) which reverse the direction of rotation of the lead screw (62) thereby reversing the direction of movement of the carriage (26).
摘要翻译： 用于被动地锻炼人体四肢的装置包括细长轨道（16），其包括在其底部形成有槽的管状壳体（46）。 螺杆（62）纵向设置在壳体中，滑架（26）与导螺杆（62）螺纹接合。 托架（26）连接到要被运动的末端，使得当滑架（26）沿着细长轨道（16）前后移动时，末端移动经过预定的运动范围。 止动构件（28）可以在滑架26的运动路径中定位在壳体上。 滑架26与停止构件（28）的接合实现了导螺杆（62）的纵向移动。 导螺杆（62）的纵向移动致动开关（110），该开关反转螺杆（62）的旋转方向，从而反转滑架（26）的运动方向。
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公开(公告)号：US4675586A
公开(公告)日：1987-06-23
申请号：US760364
申请日：1985-06-05
申请人： Otto Eigner , Richard E. Jones
发明人： Otto Eigner , Richard E. Jones
CPC分类号： H02H7/0851 , H02H7/0854 , Y10S388/909 , Y10S388/91
摘要： A monitoring circuit for a door operating D.C. electric motor, the circuit comprises a first means for detecting a back EMF of the motor and producing a load signal indicative of the magnitude of the back EMF, a second means for detecting the time rate of change of the load signal and issuing an obstruction signal if the magnitude of the time rate of change of the load signal exceeds a predetermined value.
摘要翻译： PCT No.PCT / AU84 / 00198 Sec。 371日期：1985年6月5日 102（e）日期1985年6月5日PCT提交1984年10月11日PCT公布。 公开号WO85 / 01773 1985年4月25日。一种用于门操作DC电动机的监控电路，该电路包括用于检测电动机的反电动势的第一装置，并产生指示反电动势的大小的负载信号;第二装置， 如果负载信号的时间变化率的大小超过预定值，则检测负载信号的时间变化率并发出阻塞信号。
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