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    Method and apparatus for trimming current limit and frequency to maintain a constant maximum power
    22.
    发明申请
    Method and apparatus for trimming current limit and frequency to maintain a constant maximum power 失效
    用于调整电流限制和频率以保持恒定最大功率的方法和装置

    公开(公告)号：US20050146900A1

    公开(公告)日：2005-07-07

    申请号：US11071380

    申请日：2005-03-02

    申请人： Balu Balakrishnan ,  Alex Djenguerian ,  David Matthews

    发明人： Balu Balakrishnan ,  Alex Djenguerian ,  David Matthews

    IPC分类号： H02M3/28 ,  H02M1/00 ,  H02M1/32 ,  H02M3/155 ,  H02M3/156 ,  H02M3/335 ,  H02M3/00

    CPC分类号： H02M1/32 ,  G05F3/262 ,  H02M3/156 ,  H02M3/33507 ,  H02M7/003 ,  H02M2001/0093 ,  H03K17/0822

    摘要： Methods and apparatuses to trim current limit (Ip) and frequency (f) to maintain a constant maximum power. In one aspect of the invention, a power supply regulator having a peak current limit detection threshold and an operating frequency is disclosed. The peak current limit threshold or the operating frequency are adjusted specifically to maintain the Ipm·fn product substantially constant from one power supply controller to another where m is substantially equal to 2 and n is substantially equal to 1. In another aspect of the invention, the power supply regulator has a control circuit having a control threshold current. The peak current limit threshold or the operating frequency are adjusted specifically to maintain the product of Ipm·fn divided by the control threshold current substantially constant from one power supply controller to another where m is substantially equal to 2 and n is substantially equal to 1.

    摘要翻译： 限制电流极限（I SUB）和频率（f）的方法和装置以维持恒定的最大功率。 在本发明的一个方面，公开了具有峰值电流限制检测阈值和工作频率的电源调节器。 峰值电流限制阈值或工作频率被特别地调整，以保持从一个电源控制器基本上恒定的电压I n 到另一个，其中m基本上等于2，并且n基本上等于1.在本发明的另一方面，电源调节器具有具有控制阈值电流的控制电路。 对峰值电流限制阈值或工作频率进行特殊调整，以保持I / O的乘积除以控制阈值电流 从一个电源控制器基本上恒定到另一个，其中m基本上等于2，并且n基本上等于1。

    Methods and arrangements for providing multiple concurrent desktops and workspaces in a shared computing environment
    23.
    发明申请
    Methods and arrangements for providing multiple concurrent desktops and workspaces in a shared computing environment 有权
    在共享计算环境中提供多个并发桌面和工作区的方法和安排

    公开(公告)号：US20050066202A1

    公开(公告)日：2005-03-24

    申请号：US10966571

    申请日：2004-10-15

    申请人： Christopher Evans ,  Giampiero Sierra ,  Victor Tan ,  Praerit Garg ,  David Matthews ,  Reiner Fink ,  Paul Hellyar

    发明人： Christopher Evans ,  Giampiero Sierra ,  Victor Tan ,  Praerit Garg ,  David Matthews ,  Reiner Fink ,  Paul Hellyar

    IPC分类号： G06F21/20 ,  G06F9/44 ,  G06F9/46 ,  H04L9/00

    CPC分类号： G06F9/451

    摘要： Methods and arrangements are provided for use in multiple user computing environments. These methods and arrangements can be configured to allow for a plurality of separate and concurrent desktops and workspaces within the shared computing environment. One method includes creating a separate desktop thread for each user that is authenticated during a logon process, creating a separate desktop associated with each desktop thread, and maintaining a list of desktop threads that are created. In this manner, several users can be logged on simultaneously. In certain implementations, the method further includes establishing a separate user environment associated with each desktop and launching a separate user shell associated with each desktop. The list of desktop threads allows for selective and/or automatic switching from a first desktop to a second desktop without terminating a desktop thread associated with the first desktop. The methods and arrangements are also applicable to remote process logon and switching.

    摘要翻译： 提供了在多个用户计算环境中使用的方法和布置。 这些方法和布置可以被配置为允许在共享计算环境内的多个单独的和并发的桌面和工作空间。 一种方法包括为登录过程中进行身份验证的每个用户创建单独的桌面线程，创建与每个桌面线程相关联的单独桌面，以及维护创建的桌面线程列表。 以这种方式，几个用户可以同时登录。 在某些实现中，该方法还包括建立与每个桌面相关联的单独的用户环境并且启动与每个桌面相关联的单独的用户外壳。 桌面线程列表允许从第一桌面到第二桌面的选择性和/或自动切换，而不终止与第一台桌面相关联的桌面线程。 方法和布置也适用于远程进程登录和切换。

    Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents
    25.
    发明授权
    Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents 有权
    鞘氨醇-1-磷酸受体拮抗剂和抗微管剂之间的协同作用

    公开(公告)号：US08802692B2

    公开(公告)日：2014-08-12

    申请号：US13124586

    申请日：2009-10-16

    申请人： Geetha Shankar ,  Frauke Bentzien ,  Peter Lamb ,  David Matthews

    发明人： Geetha Shankar ,  Frauke Bentzien ,  Peter Lamb ,  David Matthews

    IPC分类号： A61K31/44 ,  A01N43/36 ,  A61K31/40

    CPC分类号： A61K31/4196 ,  A61K31/16 ,  A61K31/337 ,  A61K31/34 ,  A61K31/4192 ,  A61K31/435 ,  A61K2300/00

    摘要： This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.

    摘要翻译： 本发明基于以下发现：施用鞘氨醇-1-磷酸受体拮抗剂（S1P）和选自抗微管剂组的至少一种化学治疗剂提供了对于癌症的意想不到的优异治疗。 抗菌剂如紫杉烷化合物是本领域已知的，例如紫杉醇（可从Bristol-Myers Squibb，Princeton，NJ获得），多西紫杉醇（可从Sanofi-aventis，Bridgewater，NJ获得）和 类似物和其它作为抗微管剂的化合物，如长春新碱（ONCVIN®，VINCASARPFS®，VCR），长春花碱（VELBAN®，VELSAR）和长春瑞滨等）和类似化合物。 本发明还提供了通过施用治疗有效量的至少一种鞘氨醇-1-磷酸1（S1P1R）受体拮抗剂和至少一种抗微管剂来调节所选细胞群体如癌细胞的生长的方法。

    Metropolitan IP aggregation network design tool
    27.
    发明授权
    Metropolitan IP aggregation network design tool 失效
    大都会IP​​聚合网络设计工具

    公开(公告)号：US08750161B1

    公开(公告)日：2014-06-10

    申请号：US12972651

    申请日：2010-12-20

    申请人： David Matthews ,  Promod Kumar Bhagat ,  Robert Duncan Doverspike ,  John Gregory Klincewicz ,  Jian Li ,  Guangzhi Li ,  David Frederick Lynch ,  Moshe Segal ,  Dongmei Wang

    发明人： David Matthews ,  Promod Kumar Bhagat ,  Robert Duncan Doverspike ,  John Gregory Klincewicz ,  Jian Li ,  Guangzhi Li ,  David Frederick Lynch ,  Moshe Segal ,  Dongmei Wang

    IPC分类号： H04L12/28

    CPC分类号： H04W40/02 ,  H04L45/12 ,  H04L45/64

    摘要： In a tool for use by network planners in designing metropolitan IP aggregation networks, several optimization methods are integrated into a tool. A k-means algorithm is used to choose access packet switch locations. A dual-k-means algorithm is used to choose the backbone switch locations. Each access packet switch is dual homed to two backbone packet switches using two diverse paths. The diverse path configuration is found using a maxflow-mincost algorithm on a modified fiber map topology. The link topology connecting the backbone packet switches to each other is designed using a heuristic that creates a skeleton network topology and then adds express links one by one, testing each link to assure reduced overall network cost. The resulting network topology is then improved upon by local search.

    摘要翻译： 在网络规划者用于设计城域IP聚合网络的工具中，将几种优化方法集成到工具中。 k-means算法用于选择接入分组交换机的位置。 双k均值算法用于选择主干交换机的位置。 每个接入分组交换机被双重归属到两个主干分组交换机，使用两个不同的路径。 在修改的光纤映射拓扑上使用maxflow-mincost算法找到不同的路径配置。 将骨干分组交换机连接到彼此的链路拓扑结构使用启发式设计，创建骨架网络拓扑，然后逐个添加快速链接，测试每个链路以确保降低整体网络成本。 然后通过本地搜索来改进所得到的网络拓扑。

    CREATING AN IMMERSIVE ENVIRONMENT
    29.
    发明申请
    CREATING AN IMMERSIVE ENVIRONMENT 审中-公开
    创造一个无与伦比的环境

    公开(公告)号：US20120167005A1

    公开(公告)日：2012-06-28

    申请号：US12977235

    申请日：2010-12-23

    申请人： David Matthews ,  Jesse Clay Satterfield ,  Stephan Hoefnagels ,  Alice Steinglass ,  Samuel Moreau ,  Jensen Harris

    发明人： David Matthews ,  Jesse Clay Satterfield ,  Stephan Hoefnagels ,  Alice Steinglass ,  Samuel Moreau ,  Jensen Harris

    IPC分类号： G06F3/048

    CPC分类号： G09G5/14 ,  G06F9/451 ,  G06F2203/04803 ,  G09G2340/14

    摘要： The working area of an immersive environment is presented on a display without relying on any system chrome. Two regions are defined within the immersive environment, one of which is a larger primary region and the second of which is a smaller non-primary region. The two regions are presented so that they not overlap with one another. The content of one executing user-interactive application is presented in the primary region and, simultaneously, content of one or more other executing user-interactive applications are presented in the non-primary region. In some implementations the non-primary is docked to one side of the display.

    摘要翻译： 沉浸式环境的工作区域呈现在显示屏上，而不依赖于任何系统铬。 在沉浸式环境中定义了两个区域，其中一个区域是较大的主区域，第二个区域是较小的非主区域。 呈现两个区域，使得它们彼此不重叠。 一个执行用户交互应用的内容被呈现在主要区域中，并且同时，一个或多个其他执行的用户交互应用的内容被呈现在非主要区域中。 在一些实现中，非主要对接到显示器的一侧。

    Method and apparatus for transformerless safety isolation in a power supply
    30.
    发明申请
    Method and apparatus for transformerless safety isolation in a power supply 有权
    电源中无变压器安全隔离的方法和装置

    公开(公告)号：US20070253225A1

    公开(公告)日：2007-11-01

    申请号：US11412630

    申请日：2006-04-26

    申请人： Stefan Baurle ,  David Matthews ,  Roland Saint-Pierre

    发明人： Stefan Baurle ,  David Matthews ,  Roland Saint-Pierre

    IPC分类号： H02M3/335

    CPC分类号： H02M3/07

    摘要： An apparatus and method are disclosed to provide transformerless safety isolation in a power supply. One example regulated power converter includes input terminals included in a primary circuit of the power converter. Output terminals are included in a secondary circuit of the power converter. A plurality of safety capacitors including first and second safety capacitors are also included. Each of the plurality of safety capacitors includes a respective first terminal coupled to the primary circuit and a respective second terminal coupled to the secondary circuit. The plurality of safety capacitors galvanically isolates the primary circuit from the secondary circuit. A power switch is included in the primary circuit. The power switch is coupled such that switching of the power switch causes energy to transfer between the primary and secondary circuits through the plurality of safety capacitors. Substantially all of the energy that is transferred between the primary and secondary circuits is through the plurality of safety capacitors.

    摘要翻译： 公开了一种在电源中提供无变压器安全隔离的装置和方法。 一个示例性调节功率转换器包括包括在功率转换器的初级电路中的输入端子。 输出端子被包括在功率转换器的次级电路中。 还包括包括第一和第二安全电容器的多个安全电容器。 多个安全电容器中的每一个包括耦合到主电路的相应的第一端子和耦合到次级电路的相应的第二端子。 多个安全电容器将初级电路与次级电路电隔离。 电源开关包含在主电路中。 功率开关被耦合，使得功率开关的切换导致能量通过多个安全电容器在初级和次级电路之间传递。 在主电路和次级电路之间传输的基本上所有的能量通过多个安全电容器。