公开(公告)号：US20060148761A1

公开(公告)日：2006-07-06

申请号：US11189133

申请日：2005-07-26

申请人： Michael Eaton ,  Timothy Norman ,  David Parker ,  Terence Baker ,  Andrew Weir ,  Catherine Catterall

发明人： Michael Eaton ,  Timothy Norman ,  David Parker ,  Terence Baker ,  Andrew Weir ,  Catherine Catterall

IPC分类号： A61K31/685 ,  A61K31/225

CPC分类号： A61K9/1272 ,  A61K31/225 ,  A61K31/685 ,  A61K47/543 ,  A61K47/6929 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

公开(公告)号：US20060100331A1

公开(公告)日：2006-05-11

申请号：US10534529

申请日：2005-03-02

申请人： David Parker ,  Adam Maltby ,  Martin Read ,  Philip McCoy

发明人： David Parker ,  Adam Maltby ,  Martin Read ,  Philip McCoy

IPC分类号： C08K5/09

CPC分类号： C08K5/10 ,  C08K5/101 ,  C08L67/02

摘要： Use of a compound of general formula (1) as a slip agent in a PET polymer, wherein: R and R1 represent hydrocarbon moieties, each hydrocarbon moiety comprising 6 to 24 carbon atoms and wherein R and/or R1 may be linear, branched chain, saturated or contain one or more double a bonds; X represents one of the moieties (a), wherein A represents a hydrocarbon moiety comprising 2 to 36 carbon atoms and may be linear, branched chain, saturated or contain one or more double bonds.

摘要翻译： 在PET聚合物中使用通式（1）的化合物作为增滑剂，其中：R 1和R 2代表烃部分，每个烃部分包含6至24个碳原子，并且其中R和/ 或R 1可以是直链，支链，饱和或含有一个或多个双键; X表示部分（a）之一，其中A表示包含2至36个碳原子的烃部分，并且可以是直链，支链，饱和或含有一个或多个双键。

公开(公告)号：US20060080589A1

公开(公告)日：2006-04-13

申请号：US10960492

申请日：2004-10-07

申请人： Jeffrey Holm ,  David Parker ,  Bradley Winter

发明人： Jeffrey Holm ,  David Parker ,  Bradley Winter

IPC分类号： G11C29/00

CPC分类号： G11C7/1006 ,  G06F11/1008

摘要： A method and apparatus are provided for interfacing between a data source and a tightly-coupled memory. In the method and apparatus, a write data word and a write address are received from the data source and latched in a first clock cycle within a write buffer along a write data path, between the data source and the memory. The write data word is encoded according to an error detection code along the write data path. The write address and the write data word are applied to the memory from the write buffer. The write data word is accessible to the data source from the write data path or the memory beginning with a second clock cycle, which is a next subsequent clock cycle to the first clock cycle.

摘要翻译： 提供了一种用于在数据源和紧耦合存储器之间进行接口的方法和装置。 在该方法和装置中，从数据源接收写入数据字和写入地址，并在数据源和存储器之间的写入数据路径的写入缓冲器内以第一时钟周期锁存。 写数据字根据写入数据路径的错误检测码进行编码。 写地址和写数据字从写缓冲器应用于存储器。 写入数据字可以从写入数据路径或存储器开始的数据源访问，第二个时钟周期是第一个时钟周期的下一个后续时钟周期。

公开(公告)号：US20050214124A1

公开(公告)日：2005-09-29

申请号：US10806426

申请日：2004-03-23

申请人： Todd Fischer ,  John Nolan ,  Andrew Tomko ,  Dennis Roberts ,  Carter Cook ,  David Parker

发明人： Todd Fischer ,  John Nolan ,  Andrew Tomko ,  Dennis Roberts ,  Carter Cook ,  David Parker

IPC分类号： F01D5/20 ,  B23K37/04 ,  B23K37/047 ,  B23P6/00 ,  F01D5/00 ,  F01D25/00 ,  F02C7/00 ,  F03B11/08

CPC分类号： B23P6/007 ,  F01D5/005 ,  F01D5/225 ,  F01D5/24 ,  F01D5/3053

摘要： Bucket tip tenons requiring refurbishment are removed from the bucket tips by grinding. Groups of buckets are clamped on a rotatable table in positions adjacent an induction heating coil and a robotic welding arm, respectively. While one group is preheated, the other group of buckets is in a welding location, enabling the welding head on the robotic arm to sequentially apply weld buildup material to the bucket tips. After applying weld buildup material in multiple passes and sequentially to the bucket tips, the buckets are removed, stress-relieved and the weld buildup material machined to provide refurbished tenons. Upon removal of the buckets from the table, the table is rotated to locate the preheated buckets in welding locations and additional buckets are clamped to the table for preheating.

摘要翻译： 需要翻新的铲斗榫头通过磨削从铲斗顶部移除。 一组铲斗分别夹在与感应加热线圈和机器人焊接臂相邻的位置的可旋转工作台上。 当一组预热时，另一组铲斗处于焊接位置，使得机器臂上的焊接头能够将焊接积聚材料依次施加到铲斗顶端。 在多次通过中施加焊接成型材料并依次施加到铲斗前端之后，移除铲斗，减轻应力，并加工焊接成型材料以提供翻新的榫头。 从桌子上取下铲斗后，转动桌子将预热的铲斗定位在焊接位置，另外的铲斗被夹紧在工作台上进行预热。

公开(公告)号：US20050001435A1

公开(公告)日：2005-01-06

申请号：US10610727

申请日：2003-07-01

申请人： David Parker ,  Deanna Griffith

发明人： David Parker ,  Deanna Griffith

IPC分类号： A45C13/00 ,  A45C13/10 ,  E05B65/52 ,  E05C3/06 ,  E05C19/10 ,  E05C19/12

CPC分类号： A45C13/1084 ,  A45C13/008 ,  E05B65/5276 ,  E05C3/06 ,  Y10T292/0871 ,  Y10T292/0917 ,  Y10T292/0921

摘要： A double throw latch for a carrying case has a first elongated body, a first end of the body being pivotally mounted with one part of a carrying case. There is also a second elongated body that is pivotally mounted on the first elongated body. There is a first hook element on the first elongated body, and the first hook element is located towards a second end of the first elongated body. The first hook element is for engagement with a mating first formation on a second part of the carrying case. There is also an engaging element for engagement with a portion on the first elongated body. The area adjacent to where the second elongated body pivots with the first elongated body provides an inter-engaging surface or element for engagement with an opposite face on the first part of the case. After the second elongated body is toggled a predetermined amount from the closed position, the second elongated body engages the formation of the first elongated body. The first elongated body then separates from the mating first formation of the second part of the carrying case. It thereby disengages the first hook element from the mating first formation on the second part of the case. The first elongated body pivots relative to the first part of the carrying case at a position relatively close to the body of the carrying case.

摘要翻译： 用于携带箱的双掷闩锁具有第一细长主体，主体的第一端枢转地安装有一个手提箱的一部分。 还有一个可枢转地安装在第一细长体上的第二细长体。 第一细长体上有一个第一钩元件，第一钩元件位于第一细长体的第二端。 第一钩元件用于与携带箱的第二部分上的配合第一结构接合。 还存在用于与第一细长主体上的部分接合的接合元件。 与第二细长主体与第一细长主体枢转的区域相邻的区域提供了用于与壳体的第一部分上的相对面接合的相互接合的表面或元件。 在第二细长主体从关闭位置切换预定量之后，第二细长主体接合第一细长主体的形成。 然后，第一细长主体与携带箱的第二部分的配合的第一组合分离。 从而使第一钩元件与壳体的第二部分上的配合第一形成分离。 第一细长体相对于手提箱的第一部分在相对靠近手提箱主体的位置处枢转。

公开(公告)号：US6006412A

公开(公告)日：1999-12-28

申请号：US891358

申请日：1997-07-10

申请人： John Bergmann ,  David Parker ,  Tom Sawyer

发明人： John Bergmann ,  David Parker ,  Tom Sawyer

IPC分类号： A43D1/02 ,  B23Q17/00

CPC分类号： A43D1/022 ,  A43D1/025 ,  Y10T29/49769 ,  Y10T29/49771 ,  Y10T29/49812 ,  Y10T29/49995

摘要： A method and apparatus for preparing an orthotic appliance to correct defects in a foot providing the steps of scanning a foot, creating a three-dimensional model of the corrected foot, milling a positive mold of the corrected foot, forming a uniformly thick orthotic material over the positive mold and milling out the bottom of the orthotic appliance. Also provided is a heel bisector for use in preparing an orthotic appliance.

摘要翻译： 一种用于准备矫正器具以矫正足部缺陷的方法和装置，其提供扫描足部的步骤，产生矫正足部的三维模型，研磨矫正足部的正模，形成均匀厚度的矫正材料 正模并铣出矫形器的底部。 还提供了用于制备矫形器具的脚跟平分线。

公开(公告)号：US5986466A

公开(公告)日：1999-11-16

申请号：US947165

申请日：1997-10-08

申请人： Gerald Edward Sobelman ,  David Parker

发明人： Gerald Edward Sobelman ,  David Parker

IPC分类号： H03K19/173 ,  H03K19/177

CPC分类号： H03K19/1735

摘要： A programmable gate array is disclosed for implementing asynchronous logic. In one embodiment, the array includes a set of cells, at least one of which includes a threshold gate having a plurality of inputs, an output, and a threshold value. Signals may assume an ASSERTED state having a logic meaning and a NULL state that has no logic meaning. The gate output switches to NULL when all inputs are NULL, and switches to the ASSERTED state when the number of ASSERTED inputs exceeds the threshold value. In the preferred embodiment, the gate exhibits hysteresis such that the output remains ASSERTED while the number of ASSERTED inputs remains greater than zero, and less than the threshold value. In an alternate embodiment, an array of simplified threshold elements is used to form more complex threshold gates.

摘要翻译： 公开了一种用于实现异步逻辑的可编程门阵列。 在一个实施例中，阵列包括一组单元，其中至少一个包括具有多个输入，输出和阈值的阈值门。 信号可以假设具有逻辑含义的ASSERTED状态和没有逻辑含义的NULL状态。 当所有输入为NULL时，门输出切换到NULL，当ASSERTED输入的数量超过阈值时，切换到ASSERTED状态。 在优选实施例中，门显示滞后，使得输出保持为ASSERTED，而ASSERTED输入的数量保持大于零且小于阈值。 在替代实施例中，使用简化阈值元素的阵列来形成更复杂的阈值门。

公开(公告)号：US5741927A

公开(公告)日：1998-04-21

申请号：US492064

申请日：1995-07-21

申请人： David Parker ,  John Arthur Turner ,  Ian Peter Milne

发明人： David Parker ,  John Arthur Turner ,  Ian Peter Milne

IPC分类号： B01D9/02 ,  B01D9/00 ,  C07C51/487 ,  C07C63/26 ,  C07C51/42

CPC分类号： B01D9/005

摘要： A process for the purification of terephthalic acid is disclosed. A slurry containing crystals in an impurity-containing mother liquor under elevated pressure and temperature conditions is processed to separate the crystals from the mother liquor. The processing comprises highly efficient separation and washing of the crystals under the elevated temperature and pressure conditions in a unit (32) to produce a mass of crystals having a low level of contamination. The washed crystals are reslurried in aqueous medium (vessel 40) and transferred to a secondary separation unit (34) operating under lower pressure and temperature conditions, the transfer being effected by flashing down (in vessel 44) to the lower pressure. The filtrate (41) from unit (34), and optionally wash liquor used in unit (34), is used to establish a recirculating flow whereby the aqueous medium used for reslurrying the crystals prior to pressure let-down is repeatedly re-used.

摘要翻译： PCT No.PCT / GB94 / 00248 Sec。 371日期1995年7月21日 102（e）1995年7月21日PCT PCT 1994年2月9日PCT公布。 第WO94 / 19082号公报 日本1994年9月1日公开了对苯二甲酸的纯化方法。 处理在含有杂质的母液中在升高的压力和温度条件下含有晶体的浆液，以将晶体与母液分离。 该处理包括在单元（32）中在升高的温度和压力条件下高效分离和洗涤晶体，以产生具有低污染水平的大量晶体。 将洗涤的晶体在水性介质（容器40）中再浆化，并转移到在较低压力和温度条件下操作的二次分离单元（34），转移通过在（在容器44中）闪烁来实现较低压力。 来自单元（34）的滤液（41）和任选的用于单元（34）的洗涤液用于建立再循环流动，由此重复使用在压力释放之前用于再结晶晶体的水性介质。

公开(公告)号：US5342936A

公开(公告)日：1994-08-30

申请号：US964117

申请日：1992-10-02

申请人： David Parker ,  Michael A. W. Eaton

发明人： David Parker ,  Michael A. W. Eaton

IPC分类号： A61K51/04 ,  A61K51/10 ,  C07F9/6524 ,  C07D255/02

CPC分类号： C07F9/6524 ,  A61K51/0482 ,  A61K51/1093 ,  A61K2123/00

摘要： (1) Tetra-aza macrocycles of formula (I), wherein m and n, which may be the same or different, is each zero or an integer 1,2, or 3; d is zero or an integer 1, 2 or 3; q is zero or an integer from 1 to 6 inclusive; R, R1, R2 and R3, which may be the same or different, is each a hydrogen atom or a group -P(O)(XH)R4 (where X is an oxygen or sulphur atom and R4 is a hydrogen atom or an alkyl or alkoxy group), with the proviso that at least one of R, R1, R2 and R3 is a -P(O)(XH)R4 group; L is a covalent bond or a linker group; Z is a hydrogen atom or a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules, such as proteins for use in diagnosis and therapy.

摘要翻译： （1）式（I）的四氮杂大环，其中m和n可以相同或不同，分别为零或整数1,2或3; d为零或整数1,2或3; q为0或1〜6的整数; R，R 1，R 2和R 3可以相同或不同，分别为氢原子或基团-P（O）（XH）R4（其中X为氧或硫原子，R4为氢原子或 烷基或烷氧基），条件是R，R 1，R 2和R 3中的至少一个是-P（O）（XH）R 4基团; L是共价键或连接基团; Z是氢原子或反应性官能团; 和金属络合物和/或其盐; 与其制备方法和含有它们的组合物一起描述。 所述化合物可用于成像和治疗异常细胞病症，例如治疗肿瘤，并且可以与其它分子（例如用于诊断和治疗的蛋白质）偶联。

公开(公告)号：US10974999B2

公开(公告)日：2021-04-13

申请号：US14702683

申请日：2015-05-02

申请人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

发明人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

IPC分类号： C05G3/90 ,  C09K15/28 ,  C09K15/30 ,  C09K15/20

摘要： Increasing longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors. The liquid formulation can also be comprised of nitrification inhibitors and urease inhibitors that are co-dissolved or blended solutions of each These novel formulations are designed to apply to fertilizers, especially urea and manure based fertilizers These delivery formulations provide an environmentally sound and inherently safe solvating system that improves the storage stability of the urease inhibitors by utilizing liquid organic non-water containing solvents, maintain the nitrification inhibitors in solution to storage temperatures of at least 10° C. and provides improved application to fertilizer of nitrification inhibitors. These delivery formulations enable safe storage, transport and subsequent application or blending with urea based or manure based fertilizers that can be applied to soil in either a liquid or granular form to provide improved nitrogen retention in the soil for uptake for plant life.