公开(公告)号：US20060148761A1

公开(公告)日：2006-07-06

申请号：US11189133

申请日：2005-07-26

申请人： Michael Eaton ,  Timothy Norman ,  David Parker ,  Terence Baker ,  Andrew Weir ,  Catherine Catterall

发明人： Michael Eaton ,  Timothy Norman ,  David Parker ,  Terence Baker ,  Andrew Weir ,  Catherine Catterall

IPC分类号： A61K31/685 ,  A61K31/225

CPC分类号： A61K9/1272 ,  A61K31/225 ,  A61K31/685 ,  A61K47/543 ,  A61K47/6929 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

公开(公告)号：US20080096957A1

公开(公告)日：2008-04-24

申请号：US11597962

申请日：2005-05-25

申请人： Michael Eaton ,  Timothy Norman ,  John Porter

发明人： Michael Eaton ,  Timothy Norman ,  John Porter

IPC分类号： A61K31/40 ,  A61P43/00 ,  C07D207/40

CPC分类号： A61K47/542 ,  A61K47/60

摘要： The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

摘要翻译： 本发明提供基本上具有以下元素的白蛋白结合化合物：间隔基，水溶性桥连基团，脂肪酸链和酸性基团，其特征在于酸性基团连接到脂肪酸的末端 链。 本发明还提供了与一个或多个生物活性部分连接的白蛋白结合化合物。

公开(公告)号：US20090306455A1

公开(公告)日：2009-12-10

申请号：US11922021

申请日：2006-06-14

申请人： Robert Andrew Slade ,  John Simon Owen Evans ,  David Parker ,  Russell Paul Cowburn ,  Michael Eaton

发明人： Robert Andrew Slade ,  John Simon Owen Evans ,  David Parker ,  Russell Paul Cowburn ,  Michael Eaton

IPC分类号： A61N2/10 ,  H01F1/00 ,  H01F1/04

CPC分类号： A61K41/0052 ,  A61N1/406 ,  A61N2/02 ,  B82Y5/00

摘要： A method of providing magnetised particles at a location using particles which can be switched between magnetic and non-magnetic states by exposure to a suitable magnetic field. The method comprises conveying the particles in their non-magnetic state to the location; and then exposing the particles to the suitable magnetic field so that they switch to their magnetic state.

摘要翻译： 使用可以通过暴露于合适的磁场在磁性和非磁性状态之间切换的颗粒在位置处提供磁化颗粒的方法。 该方法包括以非磁性状态将颗粒输送到该位置; 然后将颗粒暴露于合适的磁场，使其转变为其磁状态。

公开(公告)号：US20060136264A1

公开(公告)日：2006-06-22

申请号：US11022571

申请日：2004-12-21

申请人： Michael Eaton ,  J. Michael Eaton ,  Roy Fredricksen ,  Jay Mason

发明人： Michael Eaton ,  J. Michael Eaton ,  Roy Fredricksen ,  Jay Mason

IPC分类号： G06Q10/00 ,  G07G1/00

CPC分类号： G06Q30/06 ,  G06Q30/0206 ,  G06Q50/22

摘要： Accordingly to one exemplary embodiment, in a computerized system allowing consumers to view health care opportunities from a plurality of different health care providers, a method comprises providing for viewing a health care opportunity offered by a health care provider. The health care opportunity has a price. The method further comprises adjusting the price of the health care opportunity based on at least one preprogrammed criteria.

摘要翻译： 根据一个示例性实施例，在允许消费者从多个不同医疗保健提供者观看医疗保健机会的计算机化系统中，一种方法包括提供观看卫生保健提供者提供的保健机会。 保健机会有价格。 该方法还包括基于至少一个预编程标准来调整医疗保健机会的价格。

公开(公告)号：US20070197953A1

公开(公告)日：2007-08-23

申请号：US10565533

申请日：2004-07-16

申请人： Robert Slade ,  Michael Eaton

发明人： Robert Slade ,  Michael Eaton

IPC分类号： A61N1/30

CPC分类号： B82Y5/00 ,  A61K41/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61N1/406

摘要： Magnetic particles are used in therapeutic applications to disrupt a biological material. The particles have intrinsic magnetization, said magnetization being stabilised by inherent magneto-crystal line anisotropy and/or by shape anisotropy. By applying a magnetic field, the magnetic particles are induced to rotate when localised at the target biological material, thereby disrupting the material.

摘要翻译： 磁性颗粒用于治疗应用以破坏生物材料。 颗粒具有固有磁化，所述磁化由固有磁 - 晶线各向异性和/或形状各向异性稳定。 通过施加磁场，当定位在目标生物材料时，磁性颗粒被诱导旋转，从而破坏材料。