摘要:
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要:
An intervertebral disk implant is adapted to be placed between two vertebrae using a lateral insertion method. The implant is characterized by features including a first end plate having a first socket and a second end plate having a second socket with a spacer that is at least partially received in the first socket and the second socket. The implant includes at least one keel that is adapted to be inserted laterally into a vertebral body of the spine. The spacer allows for pivotal or rotational motion and also for twisting motion of the spine once the implant is inserted between vertebrae of a patient.
摘要:
A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.
摘要:
A baseball, softball and golf swing training device having a base platform, an adjustable and movable forward foot stop and an adjustable belt adjustably connected to a pair of straps for controlling the hips and may also include a pivot foot pedal for pivoting a hitter's rear foot with a heel lifting wedge, at least one adjustable pedal stopper for limiting the amount of pivot wherein the foot pedal pivots when swinging. The amount of rotation is dictated by a pair adjustable pedal stoppers and the adjustable forward foot stop dictates the distance a hitter steps forward into a pitch with the lead foot and the angle of the lead foot when stepping into a pitch. With respect to golf, the forward foot stop dictates the placement and angle of the forward foot when hitting a golf ball.
摘要:
The invention relates to a peelable multilayer coating system comprising a) a peelable coating layer and b) an absorbent top coating layer pigmented above the critical pigment volume concentration, and wherein the pigment comprises mesoporous inorganic particles.
摘要:
Systems in accordance with embodiments of the present invention can include an implant comprising a spacer for defining a minimum space between adjacent spinous processes, a distraction guide for piercing and distracting an interspinous ligament during implantation, and a binder for limiting or preventing flexion motion of the targeted motion segment. The binder can be secured to a brace associated with the implant during implantation by a capture device. In one embodiment, the capture device includes a fixed piece extending from the brace and a slidable piece associated with the fixed piece. A fastener can be rotated to pinch the binder between the slidable piece and a wall of the brace, securing the binder. A physician need not know the length of the binder prior to implantation, reducing the time required to perform a procedure.
摘要:
Systems and method in accordance with an embodiment of the present invention can includes an implant comprising a first wing, a spacer extending from the first wing, and a distraction guide. The distraction guide is arranged in a first configuration to pierce and/or distract tissue associated with adjacent spinous processes extending from vertebrae of a targeted motion segment. The implant can be positioned between the adjacent spinous processes and once positioned, the implant can be arranged in a second configuration. When arranged in a second configuration, the distraction guide can act as a second wing. The first wing and the second wing can limit or block movement of the implant along a longitudinal axis of the implant.
摘要:
Systems and method in accordance with an embodiment of the present invention can includes an implant comprising a first wing, a spacer extending from the first wing, and a distraction guide. The distraction guide is arranged in a first configuration to pierce and/or distract tissue associated with adjacent spinous processes extending from vertebrae of a targeted motion segment. The implant can be positioned between the adjacent spinous processes and once positioned, the implant can be arranged in a second configuration. When arranged in a second configuration, the distraction guide can act as a second wing. The first wing and the second wing can limit or block movement of the implant along a longitudinal axis of the implant.
摘要:
Systems and method in accordance with an embodiment of the present invention can includes an implant comprising a first wing, a spacer extending from the first wing, and a distraction guide. The distraction guide is arranged in a first configuration to pierce and/or distract tissue associated with adjacent spinous processes extending from vertebrae of a targeted motion segment. The implant can be positioned between the adjacent spinous processes and once positioned, the implant can be arranged in a second configuration. When arranged in a second configuration, the distraction guide can act as a second wing. The first wing and the second wing can limit or block movement of the implant along a longitudinal axis of the implant.
摘要:
Systems, procedures and tools for repairing, or reinforcing the spinous process. The systems and procedures provide for injecting bone cement into and optionally around the spinous process. Additional reinforcing elements may be embedded in the bone cement inside or outside the spinous process. The procedures include positioning of the guide and reinforcing elements relative to a spinous process, preparation of the spinous process for injection and injection of bone cement into the spinous process. Tools are provided to facilitate the accurate injection of bone cement. The systems and procedures increase the strength of the spinous process and enhance the applicability and outcome of spinal interventions.