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21.发明授权Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease 有权NOD2的突变与克罗恩病患者的纤维化疾病有关公开(公告)号：US07790370B2
公开(公告)日：2010-09-07
申请号：US10526256
申请日：2003-07-30
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.
摘要翻译： 本发明提供一种诊断或预测以特征在于纤维化疾病的克罗恩病的临床亚型的易感性的方法，其通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因，其中存在 纤维狭窄 - 易感性等位基因是以特征为纤维化疾病的克罗恩病的临床亚型的易感性的诊断或预测。 在本发明的方法中，克罗恩病的临床亚型可以是例如独立于小肠受累的纤维化疾病的特征。 本发明还提供了一种通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因来诊断个体的方法，其中存在纤维狭窄 - 倾向性等位基因的个体具有纤维化 克罗恩病的亚型，并基于诊断治疗患有克罗恩病的纤维化亚型的个体。
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22.发明申请METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE 审中-公开使用单核苷酸多态性在TL1A基因中预测或诊断炎症性皮肤病的方法公开(公告)号：US20100190162A1
公开(公告)日：2010-07-29
申请号：US12528055
申请日：2008-02-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K16/2875 , C07K2317/76 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2800/065 , G01N2800/50
摘要： This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another embodiment, the invention provides methods of treatment of inflammatory bowel disease by inhibition of TL1A.
摘要翻译： 本发明提供通过确定TL1A基因中遗传变异体的存在或不存在来诊断或预测对炎症性肠病易感性的方法。 在一个实施方案中，通过测定Fc-γ-R活化后TL1A产生的存在或不存在来实施本发明的方法。 在另一个实施方案中，本发明提供通过抑制TL1A治疗炎性肠病的方法。
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23.发明申请METHODS OF USING GENES AND GENETIC VARIANTS TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE 审中-公开使用基因和遗传变异体预测或诊断炎症性皮肤疾病的方法公开(公告)号：US20100021917A1
公开(公告)日：2010-01-28
申请号：US12527376
申请日：2008-02-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/172
摘要： This invention provides methods of diagnosing or predicting susceptibility to inflammatory bowel disease by determining the presence or absence of genetic variants. In one embodiment, a the invention is practiced by determining the presence or absence of NOD2 variants in an individual where the presence of NOD2 variants are indicative of susceptibility to Crohn's Disease in the individual. In another embodiment, the invention further determines the presence or absence of TLR8 variants where the presence of TLR8 variants are inflammatory bowel disease in female individuals. In another embodiment, the invention further determines the presence or absence of TR2 variant P631H where the presence of TLR2 variant P631H is indicative of susceptibility to Crohn's Disease.
摘要翻译： 本发明提供通过确定遗传变异体的存在或不存在来诊断或预测对炎症性肠病易感性的方法。 在一个实施方案中，本发明通过确定个体中NOD2变体的存在或不存在来实施，其中NOD2变体的存在指示个体对克罗恩病的易感性。 在另一个实施方案中，本发明进一步确定TLR8变体的存在或不存在，其中TLR8变体的存在是女性个体中的炎症性肠病。 在另一个实施方案中，本发明还确定TR2变体P631H的存在或不存在，其中TLR2变体P631H的存在表示对克罗恩病的易感性。
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24.发明申请METHODS OF USING PRDM1 GENETIC VARIANTS TO PROGNOSE, DIAGNOSE AND TREAT INFLAMMATORY BOWEL DISEASE 审中-公开使用PRDM1遗传变体进行预防，诊断和治疗炎症性皮肤病的方法公开(公告)号：US20130012604A1
公开(公告)日：2013-01-10
申请号：US13635643
申请日：2011-03-16
IPC分类号： C12Q1/68 , G01N27/447 , C40B30/04 , A61K35/00 , A61P1/04
CPC分类号： G01N33/6872 , G01N2800/065 , G01N2800/50
摘要： Methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis are disclosed.
摘要翻译： 通过确定一种或多种风险变体的存在或不存在来预测患者中医学难治性溃疡性结肠炎（MR-UC）的发展的方法，其中存在一种或多种风险变体表示严重和/或侵略性形式 的溃疡性结肠炎。
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25.发明申请METHODS OF USING SMAD3 AND JAK2 GENETIC VARIANTS TO DIAGNOSE AND PREDICT INFLAMMATORY BOWEL DISEASE 审中-公开使用SMAD3和JAK2遗传变异体进行诊断和预防炎症性皮肤疾病的方法公开(公告)号：US20120041082A1
公开(公告)日：2012-02-16
申请号：US13144376
申请日：2010-01-13
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Disclosed are methods of diagnosing Inflammatory Bowel Disease by determining the presence or absence of genetic variants at SMAD3 and/or JAK2 loci. Provided is a method of diagnosing a Crohn's Disease subtype in an individual by determining the presence or absence of a risk variant at the SMAD3 and/or JAK2 loci.
摘要翻译： 公开了通过确定SMAD3和/或JAK2基因座上遗传变异体的存在或不存在来诊断炎症性肠病的方法。 提供了通过在SMAD3和/或JAK2基因座处确定风险变体的存在或不存在来诊断个体中克罗恩病亚型的方法。
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26.发明申请METHODS OF DIAGNOSING AND CHARACTERIZING CANNABINOID SIGNALING IN CROHN'S DISEASE 审中-公开诊断和表征冠状动脉疾病的CANNABINOID信号的方法公开(公告)号：US20110124644A1
公开(公告)日：2011-05-26
申请号：US12993685
申请日：2009-05-20
申请人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
发明人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
IPC分类号： A61K31/5377 , C12Q1/68 , A61P1/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： Diagnosis of Crohn's Disease by determining the presence or absence of variants at the CNR2 (cannabinoid) genetic locus and serological markers is disclosed Methods of diagnosing a Crohn's Disease sub-type by determining the presence or absence of one or more risk variants at the CNR2 5 locus and the presence or absence of ASCA, OmpC, 12 and/or anti-Cbir1 antibodies are included
摘要翻译： 公开了通过确定CNR2（大麻素）遗传基因座和血清学标记物存在或不存在变异的克罗恩病的诊断方法，通过确定CNR2 5中一种或多种风险变体的存在或不存在来诊断克罗恩病亚型的方法 并且包括ASCA，OmpC，12和/或抗Cbir1抗体的存在或不存在
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27.发明授权Method of haplotype-based genetic analysis for determining risk for developing insulin resistance and coronary artery disease 失效用于确定发展胰岛素抵抗和冠状动脉疾病风险的基于单倍型的遗传分析方法公开(公告)号：US07141373B2
公开(公告)日：2006-11-28
申请号：US10463301
申请日：2003-06-16
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
摘要翻译： 公开了一种确定用于人类亚群体的感兴趣的基因组参考序列内用于大规模遗传分析的单元型的方法。 该方法可以应用于统计学评估受试者与感兴趣的表型（例如胰岛素抵抗或冠状动脉疾病）的任何统计学显着相关性的基因型。 因此，还公开了一种检测墨西哥裔美国人受试者发展胰岛素抵抗的遗传易感性的方法以及在墨西哥裔美国人受试者中发现胰岛素抵抗或冠状动脉疾病的低于正常风险的检测方法。
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公开(公告)号：US20120088245A1
公开(公告)日：2012-04-12
申请号：US13126695
申请日：2009-10-30
申请人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
发明人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
IPC分类号： C12Q1/68
CPC分类号： G01N33/6875 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2333/92 , G01N2800/042
摘要： Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.
摘要翻译： 公开了诊断代谢性胰岛素抵抗的易感性及其他相关病症的方法。 该方法通过确定在LPL基因座，LPIN1基因座和/或γ-谷氨酰转移酶水平升高的风险单倍型的存在来提供诊断西班牙裔美国人胰岛素抵抗的易感性的方法。
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公开(公告)号：US20100130600A1
公开(公告)日：2010-05-27
申请号：US12594143
申请日：2008-03-28
申请人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
发明人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
IPC分类号： C12Q1/68 , A61K31/366
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods of treating and prognosing atherosclerosis and lipid response to statin treatment by determining the presence or absence of haplotypes at the lipoprotein lipase locus. In one embodiment, the invention is practiced by evaluating the prognosis of vascular grafts in an individual undergoing statin treatment by determining the presence or absence of haplotypes at the lipoprotein locus.
摘要翻译： 本发明提供了通过测定脂蛋白脂肪酶基因座上单倍型的存在或不存在来治疗和预测动脉粥样硬化和对他汀类药物治疗的脂质反应的方法。 在一个实施方案中，本发明通过评估在接受他汀类药物治疗的个体中血管移植物的预后来确定脂蛋白基因座上单体型的存在或不存在来实施。
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30.发明授权Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes 有权用于确定发展胰岛素抵抗，冠状动脉疾病和其他表型的风险的基于单倍型的遗传分析方法公开(公告)号：US08178294B2
公开(公告)日：2012-05-15
申请号：US11564243
申请日：2006-11-28
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
摘要翻译： 公开了一种确定用于人类亚群体的感兴趣的基因组参考序列内用于大规模遗传分析的单元型的方法。 该方法可以应用于统计学评估受试者与感兴趣的表型（例如胰岛素抵抗或冠状动脉疾病）的任何统计学显着相关性的基因型。 因此，还公开了一种检测人类受试者在某些生物学条件下的遗传易感性的方法，其可能与冠状动脉疾病有关。
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