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1.发明授权Method of haplotype-based genetic analysis for determining risk for developing insulin resistance and coronary artery disease 失效用于确定发展胰岛素抵抗和冠状动脉疾病风险的基于单倍型的遗传分析方法公开(公告)号：US07141373B2
公开(公告)日：2006-11-28
申请号：US10463301
申请日：2003-06-16
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
摘要翻译： 公开了一种确定用于人类亚群体的感兴趣的基因组参考序列内用于大规模遗传分析的单元型的方法。 该方法可以应用于统计学评估受试者与感兴趣的表型（例如胰岛素抵抗或冠状动脉疾病）的任何统计学显着相关性的基因型。 因此，还公开了一种检测墨西哥裔美国人受试者发展胰岛素抵抗的遗传易感性的方法以及在墨西哥裔美国人受试者中发现胰岛素抵抗或冠状动脉疾病的低于正常风险的检测方法。
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2.发明授权Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes 有权用于确定发展胰岛素抵抗，冠状动脉疾病和其他表型的风险的基于单倍型的遗传分析方法公开(公告)号：US08178294B2
公开(公告)日：2012-05-15
申请号：US11564243
申请日：2006-11-28
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
摘要翻译： 公开了一种确定用于人类亚群体的感兴趣的基因组参考序列内用于大规模遗传分析的单元型的方法。 该方法可以应用于统计学评估受试者与感兴趣的表型（例如胰岛素抵抗或冠状动脉疾病）的任何统计学显着相关性的基因型。 因此，还公开了一种检测人类受试者在某些生物学条件下的遗传易感性的方法，其可能与冠状动脉疾病有关。
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公开(公告)号：US20120088245A1
公开(公告)日：2012-04-12
申请号：US13126695
申请日：2009-10-30
申请人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
发明人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
IPC分类号： C12Q1/68
CPC分类号： G01N33/6875 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2333/92 , G01N2800/042
摘要： Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.
摘要翻译： 公开了诊断代谢性胰岛素抵抗的易感性及其他相关病症的方法。 该方法通过确定在LPL基因座，LPIN1基因座和/或γ-谷氨酰转移酶水平升高的风险单倍型的存在来提供诊断西班牙裔美国人胰岛素抵抗的易感性的方法。
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公开(公告)号：US20100130600A1
公开(公告)日：2010-05-27
申请号：US12594143
申请日：2008-03-28
申请人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
发明人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
IPC分类号： C12Q1/68 , A61K31/366
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods of treating and prognosing atherosclerosis and lipid response to statin treatment by determining the presence or absence of haplotypes at the lipoprotein lipase locus. In one embodiment, the invention is practiced by evaluating the prognosis of vascular grafts in an individual undergoing statin treatment by determining the presence or absence of haplotypes at the lipoprotein locus.
摘要翻译： 本发明提供了通过测定脂蛋白脂肪酶基因座上单倍型的存在或不存在来治疗和预测动脉粥样硬化和对他汀类药物治疗的脂质反应的方法。 在一个实施方案中，本发明通过评估在接受他汀类药物治疗的个体中血管移植物的预后来确定脂蛋白基因座上单体型的存在或不存在来实施。
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5.发明授权Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy 有权预测需要结肠切除术的医疗屈光性溃疡性结肠炎（MR-UC）的方法公开(公告)号：US09580752B2
公开(公告)日：2017-02-28
申请号：US13140874
申请日：2009-12-24
申请人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
发明人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N2800/067
摘要： Disclosed are methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing ulcerative colitis in an individual by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis. In another embodiment, the severe form of ulcerative colitis is indicative of MR-UC.
摘要翻译： 公开了预测患者中医学难治性溃疡性结肠炎（MR-UC）的发展的方法。在一个实施方案中，公开了通过确定一种或多种风险变异体的存在或不存在来预测个体中溃疡性结肠炎的方法，其中 一种或多种风险变体的存在表示严重和/或侵略性形式的溃疡性结肠炎。 在另一个实施方案中，严重形式的溃疡性结肠炎指示MR-UC。
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6.发明申请METHODS OF PREDICTING MEDICALLY REFRACTIVE ULCERATIVE COLITIS (MR-UC) REQUIRING COLECTOMY 有权预防药物回顾性检查（MR-UC）的方法公开(公告)号：US20120053131A1
公开(公告)日：2012-03-01
申请号：US13140874
申请日：2009-12-24
申请人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
发明人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N2800/067
摘要： Disclosed are methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing ulcerative colitis in an individual by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis. In another embodiment, the severe form of ulcerative colitis is indicative of MR-UC.
摘要翻译： 公开了预测患者中医学难治性溃疡性结肠炎（MR-UC）的发展的方法。在一个实施方案中，公开了通过确定一种或多种风险变异体的存在或不存在来预测个体中溃疡性结肠炎的方法，其中 一种或多种风险变体的存在表示严重和/或侵略性形式的溃疡性结肠炎。 在另一个实施方案中，严重形式的溃疡性结肠炎指示MR-UC。
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7.发明申请公开(公告)号：US20130136720A1
公开(公告)日：2013-05-30
申请号：US13521622
申请日：2011-01-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to prognosing, diagnosing and treating of Crohn's disease. The invention also provides prognosis, diagnosis, and treatment that are based upon the presence of one or more genetic risk factors at the FUT2 genetic locus.
摘要翻译： 本发明涉及克罗恩病的预后，诊断和治疗。 本发明还提供了基于在FUT2遗传基因座处存在一种或多种遗传危险因素的预后，诊断和治疗。
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8.发明申请METHODS OF USING A NOD2/CARD15 HAPLOTYPE TO DIAGNOSE CROHN'S DISEASE 审中-公开使用NOD2 / CARD15 HAPLOTYPE诊断CROHN病的方法公开(公告)号：US20110117552A1
公开(公告)日：2011-05-19
申请号：US12902111
申请日：2010-10-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to Crohn's disease in an individual by determining the presence or absence in the individual of a disease-predisposing haplotype containing a JW1 variant allele at the NOD2/CARD15 locus, where the presence of the disease-predisposing haplotype is diagnostic of or predictive of susceptibility to Crohn's disease.
摘要翻译： 本发明提供了一种诊断或预测个体中克罗恩病易感性的方法，其通过确定个体存在或不存在在NOD2 / CARD15基因座处含有JW1变体等位基因的疾病易感单倍体，其中存在疾病 - 反义单倍型是克罗恩病易感性的诊断或预测。
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9.发明授权公开(公告)号：US06376176B1
公开(公告)日：2002-04-23
申请号：US09395345
申请日：1999-09-13
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang
IPC分类号： C12Q168
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to an autoimmune disease in an individual by determining the presence or absence in the individual of a 2-2-4 haplotype at the Notch4, HSP70-HOM and D6S273 loci, where the presence of the haplotype diagnoses or predicts susceptibility to the autoimmune disease. The methods of the invention can be particularly useful for diagnosing or predicting susceptibility to Crohn's disease, rheumatoid arthritis or type I diabetes mellitus. In a preferred embodiment, a method of the invention is used to diagnose or predict susceptibility to Crohn's disease in an individual of Ashkenazi Jewish ethnicity.
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10.发明授权Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease 有权NOD2的突变与克罗恩病患者的纤维化疾病有关公开(公告)号：US07790370B2
公开(公告)日：2010-09-07
申请号：US10526256
申请日：2003-07-30
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.
摘要翻译： 本发明提供一种诊断或预测以特征在于纤维化疾病的克罗恩病的临床亚型的易感性的方法，其通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因，其中存在 纤维狭窄 - 易感性等位基因是以特征为纤维化疾病的克罗恩病的临床亚型的易感性的诊断或预测。 在本发明的方法中，克罗恩病的临床亚型可以是例如独立于小肠受累的纤维化疾病的特征。 本发明还提供了一种通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因来诊断个体的方法，其中存在纤维狭窄 - 倾向性等位基因的个体具有纤维化 克罗恩病的亚型，并基于诊断治疗患有克罗恩病的纤维化亚型的个体。
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