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21.发明申请Substituted 2 5-diamidoindoles as ece inhibitors for the treatment of cardiovascular diseases 失效取代的2,5-二氨基吲哚作为治疗心血管疾病的ece抑制剂公开(公告)号：US20050038101A1
公开(公告)日：2005-02-17
申请号：US10490821
申请日：2002-09-16
申请人： Jens-Kerim Erguden , Thomas Krahn , Christian Schroder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
发明人： Jens-Kerim Erguden , Thomas Krahn , Christian Schroder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
IPC分类号： A61K31/404 , A61K31/427 , A61K31/433 , A61K31/4439 , A61P9/00 , A61P9/04 , A61P9/10 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/06 , C07D417/06 , C07D417/12 , A61K31/405 , C07D45/02
CPC分类号： C07D401/12 , C07D209/42
摘要： The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，以及其用于治疗人和/或动物疾病的药物。
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22.发明授权
公开(公告)号：US5545736A
公开(公告)日：1996-08-13
申请号：US370000
申请日：1995-01-09
IPC分类号： A61K31/55 , A61K31/00 , A61P31/12 , A61P43/00 , C07D223/20 , C07D405/12 , C12N9/99 , A61F31/55
CPC分类号： C07D223/20
摘要： The invention relates to 6-thiono-dibenz[b,e]azepines, to a process for their preparation and to their use as inhibitors of reverse transcriptase and in particular as antiretroviral agents.
摘要翻译： 本发明涉及6-硫杂 - 二苯并[b，e]吖庚因，其制备方法及其作为逆转录酶抑制剂，特别是作为抗逆转录病毒剂的用途。
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公开(公告)号：US08609698B2
公开(公告)日：2013-12-17
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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24.发明授权Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors 有权取代的二氢吡唑酮及其作为HIF-脯氨酰基-4-羟化酶抑制剂的用途公开(公告)号：US08524699B2
公开(公告)日：2013-09-03
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/4965 , A61K31/4725 , A61K31/4427 , A61K31/55 , C07D413/14 , C07D487/12 , C07D403/14 , C07D401/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US5457108A
公开(公告)日：1995-10-10
申请号：US122279
申请日：1993-09-17
申请人： Hanno Wild , Jutta Hansen , Jorg Lautz , Arnold Paessens
发明人： Hanno Wild , Jutta Hansen , Jorg Lautz , Arnold Paessens
IPC分类号： A61K31/13 , A61K31/27 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/66 , A61K31/675 , A61P31/12 , A61P31/18 , C07C233/33 , C07C271/20 , C07C271/52 , C07C311/06 , C07C317/28 , C07C317/44 , C07D209/18 , C07D209/42 , C07D215/48 , C07D295/13 , C07D295/20 , C07D493/08 , C07F7/18 , C07F9/40 , C07D215/38 , C07D209/14 , C07D213/04
CPC分类号： C07D295/13 , C07C271/20 , C07C317/44 , C07D209/42 , C07D215/48 , C07F7/1852 , C07F9/4006 , C07F9/4056 , C07C2103/32
摘要： The invention relates to substituted 5-oxo-di-benzo[a,d]cyclohepta-1,4-dienes of the formula (I) ##STR1## processes for their preparation and their use as retroviral agents.
摘要翻译： 本发明涉及式（I）的取代的5-氧代 - 二苯并[a，d]环庚烷-1,4-二烯，其制备方法及其作为逆转录病毒剂的用途。
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26.发明授权Aminoalkyl-substituted 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes 失效氨基烷基取代的5,6-二氢 - 二苯并[b，e]吖庚因-6,11-二酮-11-肟
公开(公告)号：US5385899A
公开(公告)日：1995-01-31
申请号：US977379
申请日：1992-11-17
IPC分类号： A61K31/00 , A61K31/55 , A61P31/12 , A61P43/00 , C07D223/20 , C07D413/12 , C12N9/99 , C07D223/16
CPC分类号： C07D223/20
摘要： The invention relates to aminoalkyl-substituted 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes, to processes for their preparation and to their use as antiretroviral agents.
摘要翻译： 本发明涉及氨基烷基取代的5,6-二氢 - 二苯并[b，e]吖庚因-6,11-二酮-11-肟，用于其制备及其作为抗逆转录病毒剂的用途。
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27.发明授权Substituted dihydropyrazolones for treating cardiovascular and hematological diseases 有权取代二氢吡唑酮用于治疗心血管和血液疾病公开(公告)号：US08653111B2
公开(公告)日：2014-02-18
申请号：US13356256
申请日：2012-01-23
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US08252817B2
公开(公告)日：2012-08-28
申请号：US11919478
申请日：2006-04-15
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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29.发明申请SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES 有权用于治疗心血管和血液病的替代二氢吡咯烷酮公开(公告)号：US20100305085A1
公开(公告)日：2010-12-02
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/4545 , C07D403/14 , A61K31/506 , A61P9/00 , A61P13/12
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.
摘要翻译： 本发明涉及式（I）的二氢吡唑酮衍生物，其生产方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管和血液学 疾病，肾脏疾病和促进伤口愈合。
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公开(公告)号：US20100063088A1
公开(公告)日：2010-03-11
申请号：US12619878
申请日：2009-11-17
申请人： Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
发明人： Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
IPC分类号： A61K31/381 , A61P35/00 , A61K31/433 , A61K31/4155 , A61K31/404 , A61K31/427 , A61K31/4025 , A61K31/40 , A61K31/341 , A61K31/437 , C07D333/36 , C07D417/12 , C07D409/12 , C07D307/68 , C07D471/04
CPC分类号： C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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