ARTIFICIAL NEPHRON DEVICE
    22.
    发明申请
    ARTIFICIAL NEPHRON DEVICE 有权
    人造尼泊尔装置

    公开(公告)号:US20130123936A1

    公开(公告)日:2013-05-16

    申请号:US13812487

    申请日:2010-12-24

    IPC分类号: A61F2/04

    摘要: The present invention relates to an artificial nephron device. The artificial nephron device comprising a multi micro channel in which while blood containing waste and water are passing therethrough the waste is separated so as to purify the blood and the separated waste is concentrated into the water to be discharged, wherein the multi micro channel comprises a glomerulus micro channel simulating a Glomerulus, a tubule micro channel simulating a Tubule, and a Henle's loop micro channel simulating a Henle's loop. According to the present invention, the device can be made smaller and can be optimized, and an artificial kidney of high efficiency can be made by the series or parallel combination of the devices, so the demand for a portable artificial kidney and the domiciliary hemodialysis system can be increased and life quality of patients suffering from chronic renal insufficiency can be improved.

    摘要翻译: 本发明涉及一种人造肾单位装置。 所述人造肾单元包括多微通道,其中当血液中含有废物和水通过所述废物时,所述废物被分离以净化所述血液,并且所分离的废物被浓缩到要排出的水中,其中所述多微通道包括 模拟小球的肾小球微通道,模拟Tubule的小管微通道,以及模拟Henle循环的Henle循环微通道。 根据本发明,可以使装置更小,并且可以优化,并且可以通过装置的串联或并联组合来制造高效率的人造肾,因此对便携式人造肾和家庭血液透析系统的需求 可以提高患者的慢性肾功能不全患者的生活质量。

    Electronic-Chemometric Controlled System and Process for the Analysis of Analytes
    23.
    发明申请
    Electronic-Chemometric Controlled System and Process for the Analysis of Analytes 审中-公开
    电子化学计量控制系统和分析物分析方法

    公开(公告)号:US20120225493A1

    公开(公告)日:2012-09-06

    申请号:US13390664

    申请日:2010-08-17

    摘要: A series of electronic-chemometric control processes to enhance the selectivity, concentration, analysis, and detec tion of chemical species (analytes) in the gas phase, such as when using SERS-based techniques. Controls consist variously of: 1) feedback of electronic signals corresponding to changes of static and variable parameters in targeted chemical species that vary according to a reduction, increase, maximization, linearization, or improved confidence in one or more chemometric output parameters; 2) methods for spatially locating the source of an analyte species; and, 3) variable duty cycling to save power and materials according to altered physical and environmental conditions within a monitored zone.

    摘要翻译: 一系列电子化学计量控制过程,以提高气相中化学物质(分析物)的选择性,浓度,分析和检测,例如使用基于SERS的技术时。 控制包括以下各项:1)对应于目标化学物种中的静态和可变参数的变化的电子信号的反馈,其根据减少,增加,最大化,线性化或改善一个或多个化学计量输出参数的置信度而变化; 2)用于空间定位分析物种源的方法; 以及3)根据被监测区域内物理和环境条件的改变来节省电力和材料的可变负荷循环。

    Methods and Apparatus for Transport of Airborne Molecules Using an Active Cyclical Vapor/Liquid Exchange
    24.
    发明申请
    Methods and Apparatus for Transport of Airborne Molecules Using an Active Cyclical Vapor/Liquid Exchange 有权
    使用活性循环蒸汽/液体交换运输空气分子的方法和装置

    公开(公告)号:US20120127465A1

    公开(公告)日:2012-05-24

    申请号:US13318983

    申请日:2010-05-07

    IPC分类号: G01J3/44

    CPC分类号: G01N33/0057 C02F2209/00

    摘要: Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.

    摘要翻译: 用于气相分析物和化合物的检测和/或分析的方法和装置。 该装置可以由含有与分析物相互作用的选定流体的微流体细胞形成,其中流体可以选择性地在气相和液相之间转变。 在流体冷凝期间,存在于流体的气相区域内的分析物群可以被输送到微流体细胞内的流体的液相区域。 在流体蒸发期间,分析物可以基本上保留在流体的液相区域内和细胞内。 这种蒸汽/液体交换的重复循环可以提供在微流体细胞内的分析物的积累,其中它们可被检测/分析。

    Device and methods of detection of airborne agents
    25.
    发明授权
    Device and methods of detection of airborne agents 有权
    空气传播剂检测装置及方法

    公开(公告)号:US08017408B2

    公开(公告)日:2011-09-13

    申请号:US12597742

    申请日:2008-04-25

    IPC分类号: G01N21/75

    摘要: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

    摘要翻译: 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法,装置和系统。 分子可以是空气传播剂,包括但不限于爆炸物,麻醉剂,危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生,并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子,同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集,从而提高检测器的灵敏度。

    Platform for chemical and biological sensing by surface-enhanced Raman spectroscopy
    26.
    发明授权
    Platform for chemical and biological sensing by surface-enhanced Raman spectroscopy 有权
    通过表面增强拉曼光谱技术进行化学和生物传感平台

    公开(公告)号:US07898658B2

    公开(公告)日:2011-03-01

    申请号:US12018763

    申请日:2008-01-23

    IPC分类号: G01J3/44

    CPC分类号: G01N21/658 Y10T428/24998

    摘要: Methods of analysis, and compositions relating to such, to determine the presence or absence of an analyte in a sample utilizing a composite substrate which facilitates surface enhanced Raman spectroscopy through the use of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented. Additionally, substrates which contain ‘hot spots’ of the form ‘metal/analyte/metal’ and substrates which facilitate the formation of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented as well as methods for making these substrates.

    摘要翻译: 分析方法以及与此相关的组合物,通过使用“金属/分析物/金属”形式的“热点”来促进表面增强拉曼光谱,从而确定样品中存在或不存在分析物, 被呈现。 此外,还提出了包含“金属/分析物/金属”形式的“热点”和促进形成“金属/分析物/金属”形式的“热点”的基板的基板以及制造这些基板的方法 。

    SERS-active absorbers for the analysis of analytes
    29.
    发明授权
    SERS-active absorbers for the analysis of analytes 有权
    用于分析分析物的SERS活性吸收剂

    公开(公告)号:US09091656B2

    公开(公告)日:2015-07-28

    申请号:US13501716

    申请日:2010-10-14

    IPC分类号: G01J3/44 G01N21/65

    CPC分类号: G01N21/658

    摘要: Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.

    摘要翻译: 固体型SERS活性基底(例如,贵金属纳米结构粉末或珠,微珠,颗粒等上的贵金属纳米颗粒涂层)包含在光学透明模块内。 这些模块允许将有分析物的流体控制引入SERS活性底物。 这些模块还允许对已经积聚在受限制的SERS活性基底上的分析物发出的SERS信号进行监测。 可以通过用于化学分析和化学检测应用的光学透明模块直接读出SERS衬底来监测这些SERS信号。

    SERS devices for the remote analysis of analytes
    30.
    发明授权
    SERS devices for the remote analysis of analytes 有权
    用于远程分析分析物的SERS设备

    公开(公告)号:US08917389B2

    公开(公告)日:2014-12-23

    申请号:US13511960

    申请日:2010-11-29

    IPC分类号: G01J3/44 G01N21/65 G01N21/17

    摘要: SERS-active materials are delivered to a remote zone, then optically interrogated to detect and analyze from a safe distance the presence of explosives or other materials which may or may not be hazardous. Delivery methods include deploying projectiles comprising SERS-active material(s) which distribute their contents upon deployment to a target zone.

    摘要翻译: SERS活性物质被运送到远程区域,然后进行光学询问,从安全的距离探测和分析爆炸物或其他可能危险的材料。 交付方式包括部署包含SERS活动材料的弹丸,将其内容部署到目标区域后将其分发。