公开(公告)号：USRE48558E1

公开(公告)日：2021-05-18

申请号：US15908703

申请日：2018-02-28

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K51/00 ,  A61K39/44 ,  C07K19/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/537 ,  A61K38/05 ,  A61K39/395 ,  A61K45/06 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.

公开(公告)号：US10981987B2

公开(公告)日：2021-04-20

申请号：US15803495

申请日：2017-11-03

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K51/00 ,  A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  C07K16/30 ,  A61K51/10 ,  A61K47/68 ,  C07K16/00 ,  C12P21/08 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US10556966B2

公开(公告)日：2020-02-11

申请号：US16170819

申请日：2018-10-25

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20170274092A1

公开(公告)日：2017-09-28

申请号：US15438418

申请日：2017-02-21

Applicant: GENENTECH, INC.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: A61K47/48 ,  C07K16/00 ,  A61K39/395 ,  C07K16/32 ,  A61K31/5517 ,  C07K19/00 ,  C07D487/16

CPC classification number: A61K31/5517 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6855 ,  A61K47/6869 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.