公开(公告)号：US11261254B1

公开(公告)日：2022-03-01

申请号：US17494545

申请日：2021-10-05

Applicant: GENMAB A/S

Inventor： Louise Koopman ,  Patrick Engelberts ,  Dennis Verzijl ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Sieto Bosgra ,  Frederikke L. Egerod ,  David Satijn ,  Esther C. W. Breij

IPC: C07K16/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention relates to antibodies binding to B7H4, including bispecific antibodies binding to B7H4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US11008399B2

公开(公告)日：2021-05-18

申请号：US17077376

申请日：2020-10-22

Applicant: GENMAB A/S

Inventor： David Satijn ,  Esther C. W. Breij ,  Bart E. C. G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC: C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K39/00

Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US10793640B2

公开(公告)日：2020-10-06

申请号：US15627921

申请日：2017-06-20

Applicant: GENMAB A/S

Inventor： Bart De Goeij ,  Edward N. Van Den Brink ,  Simone De Haij ,  Thilo Riedl ,  Rene Hoet ,  Ole Baadsgaard ,  David Satijn ,  Jan Van De Winkel ,  Paul Parren

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/32 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US10765743B2

公开(公告)日：2020-09-08

申请号：US16248402

申请日：2019-01-15

Applicant: GENMAB A/S

Inventor： Esther Breij ,  David Satijn ,  Edward Norbert Van Den Brink ,  Dennis Verzijl ,  Rob N. De Jong ,  Paul Parren ,  Riemke Van Dijkhuizen Radersma

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00 ,  C07K16/30

Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.

公开(公告)号：US10544220B2

公开(公告)日：2020-01-28

申请号：US15541594

申请日：2016-01-08

Applicant: GENMAB A/S

Inventor： Patrick Engelberts ,  Esther Breij ,  Rik Rademaker ,  Isil Altintas ,  David Satijn ,  Sandra Verploegen ,  Riemke Van Dijkhuizen Radersma ,  Edward Van Den Brink ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.

公开(公告)号：US20190160170A1

公开(公告)日：2019-05-30

申请号：US16270317

申请日：2019-02-07

Applicant: GENMAB A/S

Inventor： Esther Breij ,  David Satijn ,  Edward Norbert Van Den Brink ,  Dennis Verzijl ,  Rob N. De Jong ,  Paul Parren ,  Riemke Van Dijkhuizen Radersma

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  C07K16/30

Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.

公开(公告)号：US09492565B2

公开(公告)日：2016-11-15

申请号：US14854613

申请日：2015-09-15

Applicant: GENMAB A/S

Inventor： David Satijn ,  Sandra Verploegen ,  Wim Bleeker ,  Steen Lisby ,  Jan Van De Winkel ,  Patrick Van Berkel ,  Paul Parren

IPC: A61K39/395 ,  A61K47/48 ,  C07K16/36 ,  A61K45/06 ,  C07K16/30

CPC classification number: A61K47/48561 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/30 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.

Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。

公开(公告)号：US20250002610A1

公开(公告)日：2025-01-02

申请号：US18755457

申请日：2024-06-26

Applicant: Genmab A/S

Inventor： Bart E.C.G. De Goeij ,  Ilse Jongerius ,  Grietje Andringa ,  Madelon Paauwe ,  Theodorus Sjouuke Plantinga ,  David Satijn ,  Jamila Laoukili ,  Onno Wouter Kranenburg ,  Marije Overdijk

IPC: C07K16/46 ,  A61K39/00 ,  A61P35/04 ,  G01N33/68

Abstract: The present invention relates to a multispecific antibody comprising at least a FAPα binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US11970544B2

公开(公告)日：2024-04-30

申请号：US17353087

申请日：2021-06-21

Applicant: GENMAB A/S

Inventor： David Satijn ,  Esther C. W. Breij ,  Bart E. C. G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC: C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/565

Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US10512688B2

公开(公告)日：2019-12-24

申请号：US15325364

申请日：2015-07-10

Applicant: GENMAB A/S

Inventor： Esther Breij ,  David Satijn ,  Edward Norbert Van Den Brink ,  Dennis Verzijl ,  Rob N. De Jong ,  Paul Parren ,  Riemke Van Dijkhuizen Radersma

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00 ,  C07K16/30

Abstract: The present disclosure relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.