公开(公告)号：US20190233845A1

公开(公告)日：2019-08-01

申请号：US16338075

申请日：2017-09-29

Applicant: GenVec, Inc.

Inventor： Sebastien M. Maloveste ,  Damodar Ettyreddy ,  Douglas E. Brough

IPC: C12N15/86

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N2710/10322 ,  C12N2710/10343

Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.

公开(公告)号：US09951351B2

公开(公告)日：2018-04-24

申请号：US14879318

申请日：2015-10-09

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Damodar R. Ettyreddy

IPC: C12N15/861 ,  C12N15/86 ,  A61K38/16 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K38/16 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2830/008

Abstract: The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.

公开(公告)号：US09629906B2

公开(公告)日：2017-04-25

申请号：US14349426

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G. D. Gall

IPC: A61K39/155 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K48/005 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20160122781A1

公开(公告)日：2016-05-05

申请号：US14992152

申请日：2016-01-11

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140314717A1

公开(公告)日：2014-10-23

申请号：US14349470

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G.D. Gall ,  Duncan McVey

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343 ,  C12N2760/18034 ,  C12N2760/18522 ,  C12N2840/60

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140248308A1

公开(公告)日：2014-09-04

申请号：US14349426

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G.D. Gall

IPC: A61K39/155

CPC classification number: A61K48/005 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140248307A1

公开(公告)日：2014-09-04

申请号：US14349421

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: A61K39/155

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US11279951B2

公开(公告)日：2022-03-22

申请号：US15933689

申请日：2018-03-23

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Damodar R. Ettyreddy

IPC: C12N15/861 ,  C12N15/86 ,  A61K38/16 ,  A61K48/00

Abstract: The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.

公开(公告)号：US20210301303A1

公开(公告)日：2021-09-30

申请号：US17229098

申请日：2021-04-13

Applicant: GenVec, Inc.

Inventor： Sebastien M. Maloveste ,  Damodar Ettyreddy ,  Douglas E. Brough

IPC: C12N15/86 ,  C07K14/005

Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.

公开(公告)号：US20210269827A1

公开(公告)日：2021-09-02

申请号：US17200012

申请日：2021-03-12

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  C. Richter King

IPC: C12N15/86 ,  A61K48/00

Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.