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公开(公告)号：US10125174B2
公开(公告)日：2018-11-13
申请号：US15618740
申请日：2017-06-09
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC: C07K14/005 , A61K39/12 , C12N7/00 , A61K39/245 , A61K39/00
Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
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公开(公告)号：US20170275339A1
公开(公告)日：2017-09-28
申请号：US15618740
申请日：2017-06-09
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC: C07K14/005 , A61K39/12 , A61K39/245 , C12N7/00 , A61K39/00
CPC classification number: C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2710/10043 , C12N2710/16622 , C12N2710/16634 , C12N2799/022 , C12N2800/22
Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
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公开(公告)号：US10947560B2
公开(公告)日：2021-03-16
申请号：US15700279
申请日：2017-09-11
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
IPC: C12N15/861 , C12N15/00 , A61K48/00 , C12N15/86
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US20210269827A1
公开(公告)日：2021-09-02
申请号：US17200012
申请日：2021-03-12
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US20150140025A1
公开(公告)日：2015-05-21
申请号：US14403397
申请日：2013-05-16
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC: C07K14/005 , C12N7/00 , A61K39/245
CPC classification number: C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2710/10043 , C12N2710/16622 , C12N2710/16634 , C12N2799/022 , C12N2800/22
Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
Abstract translation: 提供了引起HSV特异性免疫应答并可用于治疗或预防HSV感染的单纯疱疹病毒（HSV）抗原。 还提供了核酸序列，多肽，载体和组合物，以及诱导针对HSV的免疫应答，治疗或预防HSV疾病，诱导针对HSV的T细胞应答以及诱导针对HSV的抗体应答的方法。
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Patent Agency Ranking
公开(公告)号：US20190100561A1
公开(公告)日：2019-04-04
申请号：US16156520
申请日：2018-10-10
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC: C07K14/005 , A61K39/12 , A61K39/245 , C12N7/00 , A61K39/00
Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
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公开(公告)号：US20180100164A1
公开(公告)日：2018-04-12
申请号：US15700279
申请日：2017-09-11
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US09790519B2
公开(公告)日：2017-10-17
申请号：US14403651
申请日：2013-05-28
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
IPC: C12N15/861 , C12N15/00 , A61K48/00 , C12N15/86
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US09676824B2
公开(公告)日：2017-06-13
申请号：US14403397
申请日：2013-05-16
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC: C07K14/005 , A61K39/12 , C12N7/00 , A61K39/245 , A61K39/00
CPC classification number: C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2710/10043 , C12N2710/16622 , C12N2710/16634 , C12N2799/022 , C12N2800/22
Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
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公开(公告)号：US20150167018A1
公开(公告)日：2015-06-18
申请号：US14403651
申请日：2013-05-28
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
Abstract translation: 本发明提供了一种复制缺陷型血清型28腺病毒载体，其特征在于包含部分血清型45腺病毒六邻体蛋白和/或血清型45纤维蛋白的一部分代替内源性血清型28六邻体和/或纤维蛋白。
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