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公开(公告)号：US20180223290A1
公开(公告)日：2018-08-09
申请号：US15698259
申请日：2017-09-07
Applicant: GenVec, Inc.
Inventor： Jason G.D. Gall , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
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2.发明授权公开(公告)号：US09388429B2
公开(公告)日：2016-07-12
申请号：US14288493
申请日：2014-05-28
Applicant: GenVec, Inc.
Inventor： Jason G. D. Gall , Douglas E. Brough , C. Richter King
IPC: C12N7/01 , C12N15/861 , C12N15/86 , C12N7/00 , C12N15/63
CPC classification number: C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
Abstract translation: 本发明提供了一种繁殖腺病毒载体的方法。 该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。 异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。 本发明还提供了包含上述细胞和腺病毒载体的系统。
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公开(公告)号：US10947560B2
公开(公告)日：2021-03-16
申请号：US15700279
申请日：2017-09-11
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
IPC: C12N15/861 , C12N15/00 , A61K48/00 , C12N15/86
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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4.发明申请METHOD FOR PROPAGATING ADENOVIRAL VECTORS ENCODING INHIBITORY GENE PRODUCTS 审中-公开用于传播编码基因产物的腺病毒载体的方法公开(公告)号：US20160304882A1
公开(公告)日：2016-10-20
申请号：US15193280
申请日：2016-06-27
Applicant: GenVec, Inc.
Inventor： Jason G.D. Gall , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
Abstract translation: 本发明提供了一种繁殖腺病毒载体的方法。 该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。 异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。 本发明还提供了包含上述细胞和腺病毒载体的系统。
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Patent Agency Ranking
公开(公告)号：US20210269827A1
公开(公告)日：2021-09-02
申请号：US17200012
申请日：2021-03-12
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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6.发明申请METHOD FOR PROPAGATING ADENOVIRAL VECTORS ENCODING INHIBITORY GENE PRODUCTS 审中-公开用于传播编码基因产物的腺病毒载体的方法公开(公告)号：US20140273228A1
公开(公告)日：2014-09-18
申请号：US14288493
申请日：2014-05-28
Applicant: GenVec, Inc.
Inventor： Jason G.D. Gall , Douglas E. Brough , C. Richter King
IPC: C12N15/86
CPC classification number: C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
Abstract translation: 本发明提供了一种繁殖腺病毒载体的方法。 该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。 异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。 本发明还提供了包含上述细胞和腺病毒载体的系统。
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公开(公告)号：US20180100164A1
公开(公告)日：2018-04-12
申请号：US15700279
申请日：2017-09-11
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US09790519B2
公开(公告)日：2017-10-17
申请号：US14403651
申请日：2013-05-28
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
IPC: C12N15/861 , C12N15/00 , A61K48/00 , C12N15/86
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：US20150167018A1
公开(公告)日：2015-06-18
申请号：US14403651
申请日：2013-05-28
Applicant: GenVec, Inc.
Inventor： Lisa Wei , Douglas E. Brough , C. Richter King
CPC classification number: C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
Abstract translation: 本发明提供了一种复制缺陷型血清型28腺病毒载体，其特征在于包含部分血清型45腺病毒六邻体蛋白和/或血清型45纤维蛋白的一部分代替内源性血清型28六邻体和/或纤维蛋白。
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