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公开(公告)号：US20190321366A1
公开(公告)日：2019-10-24
申请号：US16201221
申请日：2018-11-27
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D475/08 , C07D475/12 , C07D487/04 , C07D475/10 , C07D403/12
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20180085370A1
公开(公告)日：2018-03-29
申请号：US15659526
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D403/12 , C07D475/10 , C07D487/04 , C07D475/12 , C07D475/08
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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![SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS](/abs-image/US/2016/06/23/US20160176885A1/abs.jpg.150x150.jpg)
23.发明申请SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS 有权取代的1,2,3,4,6,8,12,12a-咔唑-1,4-甲基吡啶并[1,2-a：1'，2'-d]吡啶和治疗病毒感染的方法公开(公告)号：US20160176885A1
公开(公告)日：2016-06-23
申请号：US14815504
申请日：2015-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , Manoj C. Desai , Teresa Alejandra Trejo Martin , Elizabeth Bacon , Jeromy J. Cottell , Zhenhong R. Cai , Philip Anthony Morganelli , Mingzhe Ji , James G. Taylor , Xiaowu Chen , Michael R. Mish
IPC: C07D487/14
CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US09139541B2
公开(公告)日：2015-09-22
申请号：US14601132
申请日：2015-01-20
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/426 , A61K45/06 , C07D277/24 , C07D277/28 , A61K31/427 , A61K31/496 , C07D417/14 , A61K31/5377
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Abstract translation: 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20140316132A1
公开(公告)日：2014-10-23
申请号：US14321689
申请日：2014-07-01
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randal L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/12 , C07D475/08 , C07D475/10 , C07D475/06
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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Patent Agency Ranking
公开(公告)号：US11325930B2
公开(公告)日：2022-05-10
申请号：US17162754
申请日：2021-01-29
Applicant: Gilead Sciences, Inc.
Inventor： Eda Y. Canales , Manoj C. Desai , Eric Gorman , Jiayao Li , Roland D. Saito , James G. Taylor , Nathan E. Wright
IPC: C07D401/14 , C07F9/6558
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20210147454A1
公开(公告)日：2021-05-20
申请号：US17162754
申请日：2021-01-29
Applicant: Gilead Sciences, Inc.
Inventor： Eda Y. Canales , Manoj C. Desai , Eric Gorman , Jiayao Li , Roland D. Saito , James G. Taylor , Nathan E. Wright
IPC: C07F9/6558 , C07D401/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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![Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections](/abs-image/US/2020/06/23/US10689399B2/abs.jpg.150x150.jpg)
公开(公告)号：US10689399B2
公开(公告)日：2020-06-23
申请号：US16017371
申请日：2018-06-25
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC: A61K31/4985 , C07D413/14 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , C07D487/14 , A61K31/553
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20190134028A1
公开(公告)日：2019-05-09
申请号：US15982197
申请日：2018-05-17
Applicant: Gilead Sciences, Inc.
Inventor： Hyung-Jung Pyun , Manoj C. Desai , Haolun Jin , Mingzhe Ji , Teresa Alejandra Trejo Martin
IPC: A61K31/4985 , C07D471/14 , C07D471/18
CPC classification number: A61K31/4985 , C07D471/14 , C07D471/18
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US10172860B2
公开(公告)日：2019-01-08
申请号：US15659526
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D403/12 , A61K31/519 , C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/5377 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , C07D475/10 , A61K31/527 , A61K31/551 , A61K45/06
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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