公开(公告)号：US20250002471A1

公开(公告)日：2025-01-02

申请号：US18268469

申请日：2021-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Scott E. Lazerwith ,  Daniel G. Shore

IPC: C07D401/14 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D495/04 ,  C07D498/10

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20240383922A1

公开(公告)日：2024-11-21

申请号：US18631866

申请日：2024-04-10

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Katherine De La Fuente ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Safaa S. Jamshed ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  James B.C. Mack ,  Joshua L. Martin ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Rhiannon Thomas-Tran ,  Maoqun Tian ,  Vickie H. Tsui ,  William J. Watkins ,  Jie Xu ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/553 ,  A61K45/06

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US12077537B2

公开(公告)日：2024-09-03

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D513/06 ,  A61K31/4365 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US20240025932A1

公开(公告)日：2024-01-25

申请号：US18332587

申请日：2023-06-09

Applicant: Gilead Sciences, Inc.

Inventor： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Devan Naduthambi ,  Thomas P. Stratton ,  Peiyuan Wang

IPC: C07F9/6561 ,  A61P31/12

CPC classification number: C07F9/6561 ,  A61P31/12

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230250117A1

公开(公告)日：2023-08-10

申请号：US18301179

申请日：2023-04-14

Applicant: Gilead Sciences, Inc.

Inventor： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Devan Naduthambi ,  Thomas P. Stratton ,  Peiyuan Wang

IPC: C07F9/6561

CPC classification number: C07F9/6561

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230087744A1

公开(公告)日：2023-03-23

申请号：US17671402

申请日：2022-02-14

Applicant: Gilead Sciences, Inc.

Inventor： Mingzhe Ji ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: A61K31/4985 ,  A61K31/553 ,  C07D498/18 ,  A61K31/537 ,  C07D471/18 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20230038823A1

公开(公告)日：2023-02-09

申请号：US17357376

申请日：2021-06-24

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  C07D513/04 ,  C07D403/12 ,  A61K45/06

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US10098886B2

公开(公告)日：2018-10-16

申请号：US15588346

申请日：2017-05-05

Applicant: Gilead Sciences, Inc.

Inventor： Ernest A. Carra ,  Irene Chen ,  Katie Ann Keaton ,  Scott E. Lazerwith ,  Vahid Zia

IPC: C07D498/18 ,  A61K31/5365 ,  A61K45/06 ,  A61K9/20 ,  C07D498/14 ,  A61K31/513 ,  A61K31/553 ,  A61K31/675 ,  A61K31/683 ,  A61K31/537

Abstract: The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

公开(公告)号：US20180215769A1

公开(公告)日：2018-08-02

申请号：US15669569

申请日：2017-08-04

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: C07D498/18 ,  C07D498/14 ,  C07D471/22

CPC classification number: C07D498/18 ,  C07D471/18 ,  C07D471/22 ,  C07D487/18 ,  C07D498/04 ,  C07D498/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, Z2, or Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20180022757A1

公开(公告)日：2018-01-25

申请号：US15639833

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Anna Chiu ,  John Enquist, JR. ,  Nolan Griggs ,  Christopher Hale ,  Norihiro Ikemoto ,  Katie Ann Keaton ,  Matt Kraft ,  Scott E. Lazerwith ,  Michel Leeman ,  Zhihui Peng ,  Kate Schrier ,  Jonathan Trinidad ,  Jochem Van Herpt ,  Andrew W. Waltman

IPC: C07D498/14 ,  C07D213/82 ,  C07C237/20 ,  C07D319/06 ,  C07C237/16 ,  C07D309/40 ,  C07C235/80 ,  C07C231/02 ,  C07D498/22 ,  C07C231/12

Abstract: Methods of making compounds of Formula I are disclosed: