公开(公告)号：US20190202852A1

公开(公告)日：2019-07-04

申请号：US16212374

申请日：2018-12-06

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  A61K31/7072 ,  C07H19/073 ,  C07H19/10 ,  A61K31/7068

CPC classification number: C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  C07H19/073 ,  C07H19/10

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20180311263A1

公开(公告)日：2018-11-01

申请号：US15902690

申请日：2018-02-22

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/53 ,  A61K31/00 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K45/06 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/706 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20180072755A1

公开(公告)日：2018-03-15

申请号：US15717493

申请日：2017-09-27

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D495/04 ,  C07H7/06 ,  C07H11/04

CPC classification number: C07D495/04 ,  C07H7/06 ,  C07H11/04

Abstract: Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.

公开(公告)号：US09724360B2

公开(公告)日：2017-08-08

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07H15/18 ,  C07H7/06 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.