利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

102 条记录 (耗时 0.033 秒)

    REGULATION OF NAD(P)H OXIDASE GROWTH AND TRANSCRIPTION IN MELANOMA CELLS
    21.
    发明申请
    REGULATION OF NAD(P)H OXIDASE GROWTH AND TRANSCRIPTION IN MELANOMA CELLS 失效
    调节NAD（P）H氧化酶生长和转录在MELANOMA细胞

    公开(公告)号：US20050215624A1

    公开(公告)日：2005-09-29

    申请号：US10493936

    申请日：2002-12-19

    申请人： Thomas Kennedy

    发明人： Thomas Kennedy

    IPC分类号： A61K31/12 ,  A61K31/122 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37

    CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37 ,  A61K2300/00

    摘要： Malignant melanoma cells spontaneously generate reactive oxygen species (ROS) that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB). Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive NF-kB activation and suppress cell proliferation, the nature of the enzyme responsible for ROS production in melanoma cells has not been determined. To address this issue, we now have characterized the source of ROS production in melanoma cells. ROS are generated by isolated, cytosol-free melanoma plasma membranes, with inhibition by NAD(P)H oxidase inhibitors. The p22phox, gp91phox and p67phox components of the human phagocyte NAD(P)H oxidase, and the 91phox homolog NOX4 were demonstrated in melanomas by RT-PCR and sequencing, and protein product for both p22phox and gp91phox were detected in cell membranes by immunoassay. Normal human epidermal melanocytes expressed only p22phox and NOX4. Melanoma proliferation was reduced by NAD(P)H oxidase inhibitors and by transfection of antisense but not sense oligonucleotides for p22phox and NOX4. Also, the flavoprotein inhibitor diphenylene iodonium inhibited constitutive DNA binding of nuclear protein to the NF-kB and cyclic-AMP response element consensus oligonucleotides, without affecting DNA binding activity to AP-1 or OCT-1.

    摘要翻译： 恶性黑素瘤细胞自发产生促进转录因子核因子-κB（NF-kB）组成型激活的活性氧（ROS）。 尽管NAD（P）H氧化酶的抗氧化剂和抑制剂显着降低组成型NF-kB活化并抑制细胞增殖，但是还未确定负责黑素瘤细胞中ROS产生的酶的性质。 为了解决这个问题，我们现在已经描述了黑素瘤细胞中ROS产生的来源。 ROS由孤立的无细胞溶质黑素瘤细胞膜产生，具有NAD（P）H氧化酶抑制剂的抑制作用。 人吞噬细胞NAD（P）H氧化酶的p22phos，gp91 phox和p67Phox组分， / SUP>同源物NOX4通过RT-PCR和测序证实在黑素瘤中，并且通过免疫测定在细胞膜中检测到p22 phox和gp91 phox的蛋白质产物。 正常人类表皮黑素细胞仅表达p22Phox和NOX4。 通过NAD（P）H氧化酶抑制剂和通过转染p22Phox和NOX4的反义但不正义寡核苷酸来减少黑素瘤增殖。 此外，黄素蛋白抑制剂二亚苯基碘鎓抑制核蛋白的组成型DNA结合NF-kB和环AMP应答元件共有寡核苷酸，而不影响与AP-1或OCT-1的DNA结合活性。

    Golf ball with undercut dimples
    22.
    发明申请
    Golf ball with undercut dimples 失效
    高尔夫球带底切凹坑

    公开(公告)号：US20050187039A1

    公开(公告)日：2005-08-25

    申请号：US11026753

    申请日：2004-12-30

    申请人： Thomas Kennedy

    发明人： Thomas Kennedy

    IPC分类号： A63B37/00 ,  A63B37/12

    CPC分类号： A63B37/0004 ,  A63B37/0006 ,  A63B37/0018 ,  A63B37/0021 ,  A63B37/0024 ,  A63B37/0026 ,  A63B37/0033 ,  A63B37/0074 ,  A63B37/0075 ,  A63B37/0076

    摘要： A golf ball (20) having a plurality of standard dimples (33) and a plurality of undercut dimples (31) is disclosed herein. Each of the plurality of undercut dimples (31) has at least one undercut area portion (50) that extends into a portion of a concavity (55) of the undercut dimple (31). A covered region (70) defined by the undercut area portion (50) generates eddy currents during the flight of the golf ball (20) which creates greater turbulence at the surface (22) of the golf ball (20) allowing for greater distance.

    摘要翻译： 本文公开了具有多个标准凹坑（33）和多个底切凹坑（31）的高尔夫球（20）。 多个底切凹坑（31）中的每一个具有延伸到底切凹坑（31）的凹部（55）的一部分中的至少一个底切区域部分（50）。 由底切部分（50）限定的覆盖区域（70）在高尔夫球（20）的飞行期间产生涡流，在高尔夫球（20）的表面（22）处产生更大的湍流，允许更大的距离。

    Golf club having stepped grooves
    23.
    发明申请
    Golf club having stepped grooves 有权
    具有阶梯槽的高尔夫球杆

    公开(公告)号：US20050143187A1

    公开(公告)日：2005-06-30

    申请号：US10748052

    申请日：2003-12-30

    申请人： Thomas Kennedy

    发明人： Thomas Kennedy

    IPC分类号： A63B53/04

    CPC分类号： A63B53/04 ,  A63B53/047 ,  A63B53/0487 ,  A63B60/00 ,  A63B2053/0445

    摘要： A golf club head is characterized by stepped grooves in the striking face thereof. The serrated grooves are defined by opposed side walls each having at least one step portion intermediate the length thereof. The stepped grooves impart more consistent spin to a golf ball when struck by the club head.

    摘要翻译： 高尔夫球杆头的特征在于其击打面中的台阶槽。 锯齿形槽由相对的侧壁限定，每个侧壁具有在其长度之上的至少一个台阶部分。 当被球杆头撞击时，阶梯槽给高尔夫球赋予更一致的旋转。

    Canvas holding assembly
    29.
    发明授权
    Canvas holding assembly 有权

    公开(公告)号：US10123619B2

    公开(公告)日：2018-11-13

    申请号：US15433393

    申请日：2017-02-15

    申请人： Thomas Kennedy

    发明人： Thomas Kennedy

    IPC分类号： F16M11/04 ,  F16M11/10 ,  F16M11/28 ,  A47B97/04 ,  F16B2/06

    摘要： A canvas holding assembly for holding large and small canvases includes a base that is tripoidal. A first plate is coupled to and extends from the base. The first plate is substantially parallel to a surface upon which the base is positioned and is configured to position items of a user. A first bar is selectively extendable from a top of the base. A second bar is coupled to and extends from the first bar distal from the base. A first coupler is pivotally coupled to the second bar distal from the first bar. The first coupler is positioned above the first plate. Each of a plurality of holders is configured to couple to a canvas. Each holder comprises a second coupler that is complementary to, and positioned to couple to, the first coupler, such that the holder is configured to couple to the canvas.