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    Locking pipette tip and mounting shaft and hand-held manual pipette
    21.
    发明申请
    Locking pipette tip and mounting shaft and hand-held manual pipette 有权
    锁定移液器吸头和安装轴以及手持式手动移液器

    公开(公告)号：US20150086447A1

    公开(公告)日：2015-03-26

    申请号：US14524685

    申请日：2014-10-27

    Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    IPC: B01L3/02

    CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

    Abstract: The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.

    Abstract translation: 移液方法涉及安装和喷射一次性吸头。 移液系统具有一个或多个具有上部锁定部分和下部密封部分的尖端安装轴。 上锁定部分具有围绕安装轴间隔开并位于止动件上方的向外延伸的凸角。 刀片安装轴上的下密封部分位于挡块下方。 当安装轴插入到一次性移液管的轴环中时，套环从圆形变形并与尖端安装轴的上部锁定部分上的凸角接合。 同时，安装轴的下密封部分密封在一次性移液管尖端的筒体上。

    Programmable multi-channel pipettor with repositionable tips
    22.
    发明授权
    Programmable multi-channel pipettor with repositionable tips 有权
    可编程多通道移液器，具有可重新定位的尖端

    公开(公告)号：US08128892B2

    公开(公告)日：2012-03-06

    申请号：US13219823

    申请日：2011-08-29

    Applicant: David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    Inventor： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    IPC: B01L3/00 ,  B01L3/02 ,  G01N1/14

    CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

    Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

    Disposable Pipette Tip
    23.
    发明申请
    Disposable Pipette Tip 有权

    公开(公告)号：US20100034706A1

    公开(公告)日：2010-02-11

    申请号：US12578714

    申请日：2009-10-14

    Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    IPC: B01L3/02

    CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

    Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

    LOCKING PIPETTE TIP AND MOUNTING SHAFT
    25.
    发明申请
    LOCKING PIPETTE TIP AND MOUNTING SHAFT 有权

    公开(公告)号：US20080286157A1

    公开(公告)日：2008-11-20

    申请号：US11934381

    申请日：2007-11-02

    Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    IPC: B01L3/02

    CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

    Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

    Test tube with data matrix code markings
    27.
    发明授权
    Test tube with data matrix code markings 有权
    试管用数据矩阵代码标记

    公开(公告)号：US06372293B1

    公开(公告)日：2002-04-16

    申请号：US09399405

    申请日：1999-09-20

    Applicant: Gregory Mathus ,  Daniel J. Seguin ,  Victor A. Torti

    Inventor： Gregory Mathus ,  Daniel J. Seguin ,  Victor A. Torti

    IPC: B05D300

    CPC classification number: B01L3/5453

    Abstract: A test tube comprises a tube body of unitary construction including an enclosed sidewall and an integral bottom that together define a tubular container having an open top. The bottom has a concave interior surface and a planar exterior surface upon which machine readable data is encoded within a multi-layered opaque coating that is deposited onto the planar exterior surface to uniquely identify the test tube. The machine readable data is preferably an open (i.e., non-proprietary) data matrix code. This code is applied to the test tube by depositing a multi-layer coating onto the planar exterior of the tube bottom. The multi-layer coating may include a first layer of opaque material that is deposited onto the planar exterior surface, and a second layer of opaque material that is deposited onto the first layer. The machine readable code is formed in the multi-layered coating by removing portions of the second layer.

    Abstract translation: 试管包括整体构造的管体，其包括封闭侧壁和整体底部，所述底部共同限定具有开口顶部的管状容器。 底部具有凹入的内表面和平坦的外表面，机器可读数据被编码在多层不透明涂层内，该多层不透明涂层沉积在平面外表面上以唯一地识别试管。 机器可读数据优选地是开放（即非专有）数据矩阵代码。 该代码通过将多层涂层沉积到管底部的平面外部上而应用于试管。 多层涂层可以包括沉积在平面外表面上的第一不透明材料层和沉积在第一层上的第二不透明材料层。 通过去除第二层的部分，在多层涂层中形成机器可读代码。

    Microplates with UV permeable bottom wells
    28.
    发明授权
    Microplates with UV permeable bottom wells 失效
    具有UV透过底孔的微孔板

    公开(公告)号：US5858309A

    公开(公告)日：1999-01-12

    申请号：US621085

    申请日：1996-03-22

    Applicant: Gregory Mathus ,  Paul M. Szlosek ,  William J. Lacey

    Inventor： Gregory Mathus ,  Paul M. Szlosek ,  William J. Lacey

    IPC: G01N1/00 ,  B01L3/00 ,  B29C45/14 ,  B29D99/00 ,  B29K105/32 ,  B29L22/00 ,  B29L31/00 ,  B32B27/30 ,  C08L27/12 ,  C12M1/32 ,  G01N1/10 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

    CPC classification number: B01L3/5085 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33 ,  B01L2300/0829 ,  B01L2300/12

    Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.

    Abstract translation: 微孔板和微孔板制造方法。 微孔板被设计成允许紫外线辐射通过微板的底部孔，使得微孔板可以用于通过使用UV吸光度来测定样品。 在一个实施方案中，微板包括至少第一和第二孔，每个孔具有可UV透过的底部。 在另一个实施例中，微孔板包括具有与上部邻接的上部和下部的框架，以及设置在上部和下部之间并限定微板的至少一个孔的底部的框架。 该方法的一个实施例包括以下步骤：将一片UV可渗透材料插入到模腔中，该模腔包括成形为形成多个孔的侧壁的部分，将熔融的塑料材料注入模腔中，并冷却塑料材料以形成 微板与塑料材料形成第一和第二阱中的每一个的侧壁以及形成第一和第二孔中每一个的底部的UV透过材料片。 该方法的另一实施例包括提供限定至少一个阱的侧壁的上板，将中间层粘附到上板并将一片UV可渗透材料粘合到中间层。 该方法的另一实施例包括将具有至少一个孔的材料片插入模腔中，将熔融的塑料材料注入模腔并冷却塑料以形成微板。

    Multi-Channel Pipettor with Repositionable Tips
    30.
    发明申请
    Multi-Channel Pipettor with Repositionable Tips 有权
    具有可重定位提示的多通道移液器

    公开(公告)号：US20150030513A1

    公开(公告)日：2015-01-29

    申请号：US13952726

    申请日：2013-07-29

    Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    IPC: B01L3/02

    CPC classification number: B01L3/0237 ,  B01L3/0227 ,  B01L2200/022 ,  B01L2300/0829

    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

    Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

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