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公开(公告)号：US20150011510A1
公开(公告)日：2015-01-08
申请号：US14360991
申请日：2012-11-28
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Guiliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： C07D213/89 , A61K31/675 , A61K45/06 , A61K31/496 , C07D213/76 , C07F9/06 , C07D213/72
CPC分类号： C07D213/89 , C07D213/72 , C07D213/74 , C07D213/76 , C07D401/04 , C07F9/062
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译： 公开了用于预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物，组合物和方法。 该化合物具有通式（I）：
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公开(公告)号：US20130289065A1
公开(公告)日：2013-10-31
申请号：US13902299
申请日：2013-05-24
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A61K47/26 , A61K47/18 , A61K31/473
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20130261150A1
公开(公告)日：2013-10-03
申请号：US13902132
申请日：2013-05-24
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Melefyt , Kathleen M. Lee
IPC分类号： A61K47/00
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20220401463A1
公开(公告)日：2022-12-22
申请号：US17699522
申请日：2022-03-21
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： A61K31/675 , C07F9/6509 , C07D213/76 , A61K31/496 , A61K31/4178 , A61K31/439 , C07F9/02
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号：US11312698B2
公开(公告)日：2022-04-26
申请号：US16896135
申请日：2020-06-08
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： A61K31/4427 , A61K31/496 , C07D213/74 , C07D401/04 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675 , C07F9/6509 , A61P25/22 , A61P13/10 , A61P25/24 , A61P1/08 , A61K9/00 , A61K31/573
摘要： Fosnetupitant chloride hydrochloride having improved stability, characterized by the following chemical structure:
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公开(公告)号：US10828297B2
公开(公告)日：2020-11-10
申请号：US15923050
申请日：2018-03-16
IPC分类号： A61K31/496 , A61K9/48 , A61K31/4178 , A61K31/473 , A61K31/573 , A61K45/06 , A61K9/20 , A61K9/00
摘要： Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
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公开(公告)号：US20190177296A1
公开(公告)日：2019-06-13
申请号：US16228835
申请日：2018-12-21
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： C07D401/04 , A61K9/00 , A61K31/496 , A61K31/573 , A61K31/473 , A61P1/08 , A61P13/10 , A61P25/24 , A61P25/22
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号：US20170050993A1
公开(公告)日：2017-02-23
申请号：US15194984
申请日：2016-06-28
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J Stella
IPC分类号： C07F9/6509 , A61K31/675 , A61K31/473
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译： 公开了用于预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物，组合物和方法。 该化合物具有通式（I）：
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公开(公告)号：US20160296510A1
公开(公告)日：2016-10-13
申请号：US15190019
申请日：2016-06-22
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A61K31/473 , A61K47/18 , A61K47/26 , A61K9/00 , A61K9/08
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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30.发明授权4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator 有权-4-（5-（2-（3,5-双（三氟甲基）苯基）-N，2-二甲基丙酰胺基）-4-（邻甲苯基）吡啶-2-基）-1-甲基-1 - （（膦酰氧基 ）甲基）哌嗪-1-酮作为神经激肽受体调节剂公开(公告)号：US09403772B2
公开(公告)日：2016-08-02
申请号：US14360991
申请日：2012-11-28
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J Stella
IPC分类号： C07D401/04 , C07D213/74 , C07D213/89 , C07F9/06 , C07D213/72 , C07D213/76
CPC分类号： C07D213/89 , C07D213/72 , C07D213/74 , C07D213/76 , C07D401/04 , C07F9/062
摘要： Compounds and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor, based on 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)3yridine-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium and pharmaceutically acceptable salts thereof.
摘要翻译： 基于4-（5-（2-（3,5-双（三氟甲基）苯基）-N，2-（3,5-二（3,5-二（三氟甲基）苯基） - 苯并恶唑）的预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物和方法 二甲基丙酰胺基）-4-（邻甲苯基）吡啶-2-基）-1-甲基-1 - （（膦酰氧基）甲基）哌嗪-1-酮及其药学上可接受的盐。
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