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公开(公告)号：US20200276259A1
公开(公告)日：2020-09-03
申请号：US16751836
申请日：2020-01-24
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor de Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： A61K38/05 , C07D401/06 , A61P3/04 , C07D401/12 , C07K5/062 , A61K9/16
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US20180194788A1
公开(公告)日：2018-07-12
申请号：US15874325
申请日：2018-01-18
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： C07F9/6509 , C07D401/04 , C07D213/89 , C07D213/74 , A61K45/06 , A61K31/44 , A61K31/56 , A61K31/496 , A61K31/473 , A61K31/675
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号：US09872883B2
公开(公告)日：2018-01-23
申请号：US15135147
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/06 , C07D401/12 , A61K31/445 , A61K38/05 , C07K5/062 , A61K9/16
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US10717721B2
公开(公告)日：2020-07-21
申请号：US16228835
申请日：2018-12-21
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： C07D213/74 , C07D401/04 , A61K31/496 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675 , C07F9/6509 , A61P25/22 , A61P13/10 , A61P25/24 , A61P1/08 , A61K9/00 , A61K31/573
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号：US10576122B2
公开(公告)日：2020-03-03
申请号：US16383623
申请日：2019-04-14
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor de Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/06 , A61K31/454 , A61K38/05 , C07D401/12 , C07K5/062 , A61K9/16
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US10208073B2
公开(公告)日：2019-02-19
申请号：US15874325
申请日：2018-01-18
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J Stella
IPC分类号： C07D213/74 , C07D453/02 , C07J9/00 , C07F9/6509 , C07D401/04 , A61K31/496 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675
摘要： Disclosed is a solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium (fosnetupitant) and palonosetron hydrochloride in combination with dexamethasone and its application in methods for preventing acute and delayed nausea and vomiting in a human patient receiving highly emetogenic cancer chemotherapy.
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公开(公告)号：US09981002B2
公开(公告)日：2018-05-29
申请号：US15135051
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor de Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/06 , A61K31/454 , A61K38/05 , C07D401/12 , C07K5/062 , A61K9/16
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US09908907B2
公开(公告)日：2018-03-06
申请号：US15194984
申请日：2016-06-28
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J Stella
IPC分类号： A61K31/496 , A61K31/4427 , C07D213/74 , C07D401/04 , C07F9/6509 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号：US20160229889A1
公开(公告)日：2016-08-11
申请号：US15135051
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor de Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07K5/062
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US20190231843A1
公开(公告)日：2019-08-01
申请号：US16383623
申请日：2019-04-14
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor de Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： A61K38/05 , A61K9/16 , C07D401/12 , C07D401/06 , C07K5/062
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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