公开(公告)号：US07613495B2

公开(公告)日：2009-11-03

申请号：US09997894

申请日：2001-11-30

申请人： Michael Hutchinson

发明人： Michael Hutchinson

IPC分类号： A61B5/055

CPC分类号： G06T7/0012 ,  A61B5/055 ,  A61B5/4082 ,  G01R33/483 ,  G01R33/4838 ,  G01R33/50 ,  G06T2207/30016

摘要： A method of detecting Parkinson's disease through MRI of substantial nigra pars compacta (SNc) tissue. The method involves obtaining a gray matter suppressed (GMS) MRI signal from the SNc tissue, obtaining a white matter suppressed (WMS) MRI signal of the SNc tissue, and combining information from the GMS and WMS MRI signals to produce resultant signals indicative of Parkinson's disease. A similar method can be used to detect Progressive Supranuclear Palsy. A method of distinguishing between the two diseases involves obtaining at least two starting MRI images of SNc tissue using different MRI parameters, and combining the starting images to compute resultant signals differentiating between the two forms of parkinsonism.

摘要翻译： 通过大量黑质（SNc）组织的MRI检测帕金森病的方法。 该方法包括从SNc组织获得灰质抑制（GMS）MRI信号，获得SNc组织的白质抑制（WMS）MRI信号，以及组合来自GMS和WMS MRI信号的信息，产生指示帕金森病 疾病。 可以使用类似的方法来检测进行性核上麻痹。 区分两种疾病的方法包括使用不同的MRI参数获得SNc组织的至少两个起始MRI图像，并组合起始图像以计算区分两种形式的帕金森综合征之间的结果信号。

公开(公告)号：US20060217651A1

公开(公告)日：2006-09-28

申请号：US11444745

申请日：2006-06-01

申请人： Michael Hutchinson ,  Dennis Briggs ,  Stephen Gara ,  Tom Watters

发明人： Michael Hutchinson ,  Dennis Briggs ,  Stephen Gara ,  Tom Watters

IPC分类号： A61M37/00

CPC分类号： F04B43/1292 ,  A61M1/0227 ,  A61M1/3627 ,  A61M1/3633 ,  A61M1/3681 ,  A61M1/3686 ,  A61M1/3696 ,  A61M2205/125 ,  A61M2205/128 ,  A61M2205/3561 ,  A61M2205/75 ,  F04B43/0081

摘要： A control deck and system for controlling and driving blood fluids through an extracorporeal blood circuit kit. In one aspect, the invention is a deck having an improved mechanism for securing a cassette in place during treatment operations. The improved deck comprises catches for slidably receiving tabs of the cassette and one or more rotating clamps for locking and securing the cassette in a loaded position. In another aspect the invention is a system for controlling and driving blood fluids having infrared communication abilities to transmit and receive real time data. In still another aspect, the invention is a system for controlling and driving blood fluids having an upright tower design that reduces the footprint of the system. In this embodiment, a centrifuge chamber is positioned in an upper portion of the system while the control deck and photoactivation chamber are located in a base portion of the system.

摘要翻译： 用于通过体外血液回路套件控制和驱动血液的控制台和系统。 一方面，本发明是一种具有用于在处理操作期间将盒固定到位的改进机构的甲板。 改进的平台包括用于可滑动地接收盒的突片的卡扣和用于将盒子锁定并固定在加载位置的一个或多个旋转夹具。 在另一方面，本发明是一种用于控制和驱动具有红外通信能力以传输和接收实时数据的血液流体的系统。 在另一方面，本发明是一种用于控制和驱动具有直立塔架设计的血液流体的系统，其减小了系统的占地面积。 在该实施例中，离心机室位于系统的上部，而控制台和光活化室位于系统的基部。

公开(公告)号：US07108662B2

公开(公告)日：2006-09-19

申请号：US10087579

申请日：2002-02-28

申请人： Rod Miller ,  Michael Hutchinson ,  Peter J. Sagona ,  Michael Bucholtz

发明人： Rod Miller ,  Michael Hutchinson ,  Peter J. Sagona ,  Michael Bucholtz

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： B01L3/508 ,  B01L3/5023 ,  B01L2300/046 ,  B01L2300/047 ,  B01L2300/0609 ,  G01N35/1016

摘要： A collection device for a testing system includes a central volume and a trough, adjacent the central volume. The trough is configured with a pour spout such that, as fluid is poured from the collection device, a controlled volume remains in the trough. The trough is configured to receive a portion of a test kit and to apply the controlled volume of the sample to test strips within the test kit. The trough can also include apertures in the wall between the trough and the central volume which allow excess sample to flow back into the cup when the cup is placed upright after pouring and when the test kit is inserted into the trough.

公开(公告)号：US20050049196A1

公开(公告)日：2005-03-03

申请号：US10927301

申请日：2004-08-26

申请人： Michael Hutchinson ,  John Gianutsos

发明人： Michael Hutchinson ,  John Gianutsos

IPC分类号： A61K9/00 ,  A61K38/18

CPC分类号： A61K9/0085 ,  A61K38/185

摘要： The present invention provides a method of delivering a treatment to the central nervous system, including the steps of administering a therapeutic intramuscularly into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves, and transporting the therapeutic peripherally through nerves into the CNS and to the site of treatment. The present invention provides a method of treating a neural disorder or a part of the body by administering an effective amount of a compound affecting neural cells into muscles innervated by cranial and/or spinal nerves, and affecting neural cells. The present invention also provides a method of treating a spinal cord injury by administering an effective amount of a compound affecting neural cells into musculature directly innervated by the spinal cord, and affecting neural cells. The present invention further provides a method of treating Parkinson's disease by administering an effective amount of a compound affecting neural cells into musculature innervated by the motor trigeminal nerve, and affecting neural cells involved in Parkinson's disease. Finally, the present invention also provides a method of treating amyotrophic lateral sclerosis by administering an effective amount of a compound affecting neural cells into musculature innervated by cranial and/or spinal nerves, and affecting neural cells involved in amyotrophic lateral sclerosis.

摘要翻译： 本发明提供了向中枢神经系统递送治疗的方法，包括以下步骤：肌内注射治疗由神经和脊神经组成的组所选择的神经所支配的肌肉，并将治疗剂通过神经外周输送到 CNS和治疗现场。 本发明提供了一种通过将有效量的影响神经细胞的化合物施用于由颅神经和/或脊神经支配的肌肉并影响神经细胞来治疗神经障碍或身体部分的方法。 本发明还提供了一种通过将有效量的影响神经细胞的化合物施用于由脊髓直接支配的肌肉组织并影响神经细胞来治疗脊髓损伤的方法。 本发明还提供了一种治疗帕金森病的方法，其通过将有效量的影响神经细胞的化合物施用于由运动性三叉神经所支配的肌肉组织，并影响涉及帕金森病的神经细胞。 最后，本发明还提供了一种治疗肌萎缩性侧索硬化症的方法，其通过将有效量的影响神经细胞的化合物施用于由颅神经和/或脊神经支配的肌肉组织中，并影响涉及肌萎缩性侧索硬化的神经细胞。