Preparation of .alpha.-ketocarboxylic acid N-tert.-butylamides
    21.
    发明授权
    Preparation of .alpha.-ketocarboxylic acid N-tert.-butylamides 失效
    α-酮羧酸N-叔丁基酰胺的制备

    公开(公告)号:US4345100A

    公开(公告)日:1982-08-17

    申请号:US222222

    申请日:1981-01-02

    CPC分类号: C07D253/075

    摘要: A process for the preparation of an .alpha.-ketocarboxylic acid N-tert.-butylamide of the formulaR--CO--CO--NH--C(CH.sub.3).sub.3in whichR is an aliphatic radical with up to 8 carbon atoms, a cycloalkyl radical with 3 to 6 carbon atoms, a phenyl or naphthyl radical or a heterocyclic radical,comprising reacting an acyl cyanide of the formulaR--CO--CNwith tert.-butyl methyl ether of the formula(CH.sub.3).sub.3 C--O--CH.sub.3at a temperature between about 0.degree. and 80.degree. C. in the presence of an acid which is capable of activating the ether of formula (III) under the reaction conditions to give a tert.-butyl carbonium ion, and then hydrolyzing the reaction mixture. Advantageously the acyl cyanide is pivaloyl cyanide or benzoyl cyanide and is reacted with an approximately equimolar amount of the ether in the presence of about 1.1 to 1.5 times the molar amount of concentrated sulphuric acid as the activating acid. The products are useful as intermediates in the synthesis of known herbicides.

    摘要翻译: 制备式R-CO-CO-NH-C(CH3)3的α-酮羧酸N-叔丁基酰胺的方法,其中R是具有至多8个碳原子的脂族基团,环烷基 具有3至6个碳原子,苯基或萘基或杂环基,其包括使式R-CO-CN的酰基氰与式(CH 3)3 C-O-CH 3的叔丁基甲基醚在 在能够在反应条件下活化式(III)的醚的酸存在下,温度在约0℃至80℃之间,得到叔丁基碳鎓离子,然后水解反应混合物。 有利地,酰基氰是新戊酰氰或苯甲酰氰,并且在作为活化酸的浓硫酸的摩尔量的约1.1至1.5倍的存在下,与约等摩尔量的醚反应。 该产品可用作合成已知除草剂的中间体。

    Process for the preparation of dialkyl carbonates
    24.
    发明授权
    Process for the preparation of dialkyl carbonates 失效
    制备碳酸二甲酯的方法

    公开(公告)号:US5231213A

    公开(公告)日:1993-07-27

    申请号:US910475

    申请日:1992-07-08

    CPC分类号: C07C68/00 Y02P20/582

    摘要: Dialkyl carbonates can be prepared by reaction of carbon monoxide with alkyl nitrites in continuous gas phase reaction, in which a platinum metal halide catalyst on aluminum oxides, aluminum oxide hydrates or aluminum hydroxides as support and, if desired, an additive comprising an antimony, bismuth, aluminum, copper, vanadium, niobium, tantalum, tin, iron, cobalt, nickel compound or a mixture of a plurality thereof on this catalyst are used and hydrogen halide is replaced during the course of the reaction batchwise or continuously in at least the amount which is discharged from the reactor together with the reaction mixture. This results in the formation of dialkyl carbonates in almost quantitative selectivity, while the corresponding dialkyl oxalates can not in most cases be detected. The abovementioned supports are characterized by a BET surface area of more than 1 m.sup.2 /g.

    摘要翻译: 碳酸二烷基酯可以通过在连续气相反应中一氧化碳与亚硝酸烷基酯的反应来制备,其中在氧化铝上的铂金属卤化物催化剂,作为载体的氧化铝水合物或氢氧化铝,以及如果需要,包含锑,铋 在该催化剂上使用铝,铜,钒,铌,钽,锡,铁,钴,镍化合物或其多种混合物,并且在反应过程中间歇或连续地以至少量的量替换卤化氢 其与反应混合物一起从反应器排出。 这导致几乎定量选择性形成碳酸二烷基酯,而在大多数情况下相应的草酸二烷基酯不能被检测到。 上述载体的特征在于BET表面积大于1m 2 / g。

    Process for the preparation of substituted benzaldehydes
    28.
    发明授权
    Process for the preparation of substituted benzaldehydes 失效
    取代的苯甲醛的制备方法

    公开(公告)号:US4622429A

    公开(公告)日:1986-11-11

    申请号:US640414

    申请日:1984-08-13

    CPC分类号: C07C45/49

    摘要: Substituted benzaldehydes are prepared by reaction of the substituted benzenes from which they are derived with carbon monoxide and hydrogen chloride in the presence of metal halides, the process being performed in the presence of 0.5 to 10 mols of hydrogen chloride per mol of metal halide at a partial pressure of carbon monoxide from 1 to 100 bars and a temperature from -20.degree. C. to +100.degree. C. and, if desired, in the presence of an inert diluent. The substituted benzaldehyde which contains, as a substituent, alkyl with at least 2 carbon atoms, cycloalkyl or optionally substituted benzyl, is prepared by reacting the appropriately substituted benzene with the additional presence of a benzene which does not contain the substituents mentioned, but which is identical in respect of further substituents which are optionally present with the benzene from which it is derived.

    摘要翻译: 取代的苯甲醛通过在金属卤化物存在下使衍生自它们的取代苯与氯化氢反应来制备,该方法是在0.5至10摩尔氯化氢/摩尔金属卤化物存在下进行的 一氧化碳分压为1至100巴,温度为-20℃至+100℃,如果需要,在惰性稀释剂存在下进行。 含有至少2个碳原子的烷基取代的苯甲醛,环烷基或任意取代的苄基,是通过使适当取代的苯与不含上述取代基的苯进一步存在而制备的, 对于任选存在于其衍生的苯的另外的取代基是相同的。

    Process for the preparation of cinnamic acids which are optionally
substituted in the nucleus
    29.
    发明授权
    Process for the preparation of cinnamic acids which are optionally substituted in the nucleus 失效
    在核中任选取代的肉桂酸的制备方法

    公开(公告)号:US4613692A

    公开(公告)日:1986-09-23

    申请号:US743254

    申请日:1985-06-11

    CPC分类号: C07C51/353

    摘要: A process for the preparation of cinnamic acid is provided by the present invention in which an optionally substituted benzaldehyde and alkali metal salt of carboxylic acid and/or alkali metal (bi) carbonate, as condensing agents, are heated up to a temperature of 100.degree.-220.degree. C. and thereafter there is introduced into the so heated mixture acetic anhydride in at least a stoichiometric amount based upon the amount of optionally substituted benzaldehyde employed. The process can be carried out by heating up a reaction mixture to 100.degree.-220.degree. C. which is free of acetic anhydride or one which contains acetic anhydride but less than a stoichiometric amount thereof based upon the amount of optionally substituted benzaldehyde.

    摘要翻译: 通过本发明提供了制备肉桂酸的方法,其中将任选取代的苯甲醛和羧酸和/或碱金属(bi)碳酸盐的碱金属盐作为缩合剂加热至100℃ -220℃,然后基于所使用的任选取代的苯甲醛的量,以至少化学计量的量将如此加热的混合物乙酸酐引入。 该方法可以通过将反应混合物加热至不含乙酸酐的100℃-220℃或基于任选取代的苯甲醛的量而含有乙酸酐但少于其化学计量的反应混合物进行。