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21.发明授权Biosensors for biological or chemical analysis and systems and methods for same 有权用于生物或化学分析的生物传感器及其系统和方法公开(公告)号：US08906320B1
公开(公告)日：2014-12-09
申请号：US13833619
申请日：2013-03-15
Applicant: Illumina Inc.
Inventor： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi
CPC classification number: G06F17/303 , G01N21/6486 , G01N33/6875
Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.
Abstract translation: 提供了一种生物传感器，包括检测装置和安装在检测装置上的流通池。 该检测装置具有多个反应位置的检测器表面。 检测装置还包括滤波器层，其被配置为以下中的至少一个：（a）滤除不需要的激发光信号; （b）从被指定的反应部位向被配置成检测来自指定反应部位的发射信号的一个或多个相关联的光检测器的直接发射信号; 或（c）阻止或阻止从相邻反应位点检测串扰发射信号。
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公开(公告)号：US12048928B2
公开(公告)日：2024-07-30
申请号：US17848840
申请日：2022-06-24
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Tarun Khurana , Behnam Javanmardi , Poorya Sabounchi , Majid Aghababazadeh
IPC: B01L3/00 , B01L7/00 , C12Q1/6869 , C12Q1/6874
CPC classification number: B01L3/502715 , B01L3/5085 , B01L7/52 , C12Q1/6869 , C12Q1/6874 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622
Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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公开(公告)号：US11604775B2
公开(公告)日：2023-03-14
申请号：US17304758
申请日：2021-06-25
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi , Tarun Khurana
Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.
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公开(公告)号：US11385162B2
公开(公告)日：2022-07-12
申请号：US17148214
申请日：2021-01-13
Applicant: Illumina, Inc.
Inventor： Arnaud Rival , Ali Agah , Tracy H. Fung , Dietrich Dehlinger , Poorya Sabounchi , Tarun Khurana , Craig M. Ciesla , M. Shane Bowen
IPC: G01N15/14
Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.
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公开(公告)号：US11333604B2
公开(公告)日：2022-05-17
申请号：US16948524
申请日：2020-09-22
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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Patent Agency Ranking
公开(公告)号：US10921233B2
公开(公告)日：2021-02-16
申请号：US16567224
申请日：2019-09-11
Applicant: Illumina, Inc.
Inventor： Arnaud Rival , Ali Agah , Tracy H. Fung , Dietrich Dehlinger , Poorya Sabounchi , Tarun Khurana , Craig M. Ciesla , M. Shane Bowen
IPC: G01N15/14
Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.
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27.发明申请公开(公告)号：US20190351414A1
公开(公告)日：2019-11-21
申请号：US16529397
申请日：2019-08-01
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Tarun Khurana , Behnam Javanmardi , Poorya Sabounchi , Majid Aghababazadeh
IPC: B01L3/00 , B01L7/00 , C12Q1/6874 , C12Q1/6869
Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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公开(公告)号：US20180341649A1
公开(公告)日：2018-11-29
申请号：US15995767
申请日：2018-06-01
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi
Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.
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29.发明申请公开(公告)号：US20180214871A1
公开(公告)日：2018-08-02
申请号：US15936165
申请日：2018-03-26
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Tarun Khurana , Behnam Javanmardi , Poorya Sabounchi , Majid Aghababazadeh
IPC: B01L3/00 , C12Q1/6874 , C12Q1/6869 , B01L7/00
CPC classification number: B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , C12Q1/6869 , C12Q1/6874
Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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公开(公告)号：US09937497B2
公开(公告)日：2018-04-10
申请号：US15205275
申请日：2016-07-08
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Tarun Khurana , Behnam Javanmardi , Poorya Sabounchi , Majid Aghababazadeh
CPC classification number: B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , C12Q1/6869 , C12Q1/6874
Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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