公开(公告)号：US12087797B2

公开(公告)日：2024-09-10

申请号：US18175836

申请日：2023-02-28

申请人： Illumina, Inc.

发明人： Xiuyu Cai ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger

IPC分类号： H01L27/146 ,  G01J1/02 ,  G01J1/44 ,  G01N21/05 ,  G01N21/64

CPC分类号： H01L27/14636 ,  G01J1/0209 ,  G01J1/0214 ,  G01J1/44 ,  G01N21/6454 ,  H01L27/14601 ,  H01L27/14609 ,  H01L27/1462 ,  H01L27/14625 ,  H01L27/14629 ,  H01L27/14643 ,  G01N21/05 ,  G01N2201/0642 ,  H01L27/14623

摘要： An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

公开(公告)号：US11747263B2

公开(公告)日：2023-09-05

申请号：US17811750

申请日：2022-07-11

申请人： Illumina, Inc.

发明人： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC分类号： G01N15/14

CPC分类号： G01N15/1404 ,  G01N15/1429 ,  G01N2015/145

摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

公开(公告)号：US11610928B2

公开(公告)日：2023-03-21

申请号：US17119909

申请日：2020-12-11

申请人： Illumina, Inc.

发明人： Xiuyu Cai ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger

IPC分类号： H01L27/146 ,  G01J1/44 ,  G01J1/02 ,  G01N21/64 ,  G01N21/05

摘要： An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

公开(公告)号：US11852586B2

公开(公告)日：2023-12-26

申请号：US17734953

申请日：2022-05-02

申请人： Illumina, Inc.

发明人： Tracy H. Fung ,  Poorya Sabounchi ,  Bernard Hirschbein ,  Joseph Pinto ,  Tarun Khurana ,  Randall Smith ,  Wenyi Feng

IPC分类号： G01N21/64 ,  G01N33/53

CPC分类号： G01N21/6428 ,  G01N21/6454 ,  G01N33/53 ,  G01N2021/6471 ,  G01N2201/08

摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.

公开(公告)号：US20200166461A1

公开(公告)日：2020-05-28

申请号：US16778935

申请日：2020-01-31

申请人： Illumina, Inc.

发明人： Tracy H. Fung ,  Poorya SABOUNCHI ,  Bernard HIRSCHBEIN ,  Joseph PINTO ,  Tarun KHURANA ,  Randall SMITH ,  Wenyi FENG

IPC分类号： G01N21/64 ,  G01N33/53

摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.

公开(公告)号：US11385162B2

公开(公告)日：2022-07-12

申请号：US17148214

申请日：2021-01-13

申请人： Illumina, Inc.

发明人： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC分类号： G01N15/14

摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

公开(公告)号：US11333604B2

公开(公告)日：2022-05-17

申请号：US16948524

申请日：2020-09-22

申请人： Illumina, Inc.

发明人： Tracy H. Fung ,  Poorya Sabounchi ,  Bernard Hirschbein ,  Joseph Pinto ,  Tarun Khurana ,  Randall Smith ,  Wenyi Feng

IPC分类号： G01N21/64 ,  G01N33/53

摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.

公开(公告)号：US10921233B2

公开(公告)日：2021-02-16

申请号：US16567224

申请日：2019-09-11

申请人： Illumina, Inc.

发明人： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC分类号： G01N15/14

摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

公开(公告)号：US12123833B2

公开(公告)日：2024-10-22

申请号：US18512284

申请日：2023-11-17

申请人： Illumina, Inc.

发明人： Tracy H. Fung ,  Poorya Sabounchi ,  Bernard Hirschbein ,  Joseph Pinto ,  Tarun Khurana ,  Randall Smith ,  Wenyi Feng

IPC分类号： G01N21/64 ,  G01N33/53

CPC分类号： G01N21/6428 ,  G01N21/6454 ,  G01N33/53 ,  G01N2021/6471 ,  G01N2201/08

摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.

公开(公告)号：US10883937B2

公开(公告)日：2021-01-05

申请号：US16778935

申请日：2020-01-31

申请人： Illumina, Inc.

发明人： Tracy H. Fung ,  Poorya Sabounchi ,  Bernard Hirschbein ,  Joseph Pinto ,  Tarun Khurana ,  Randall Smith ,  Wenyi Feng

IPC分类号： G01N21/64 ,  G01N33/53

摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.