公开(公告)号：US12264361B2

公开(公告)日：2025-04-01

申请号：US17643454

申请日：2021-12-09

Applicant: Illumina, Inc. ,  Illumina Cambridge Limited

Inventor： Lewis Kraft ,  Craig Lee Hetherington ,  Craig M. Ciesla ,  Michael Burek ,  Jeffrey Fisher ,  Jason Betley

IPC: C12Q1/6869 ,  H01L27/146

Abstract: An image sensor structure includes an image layer having an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with a light detector. An array of nanowells is disposed over the device stack. Each nanowell is associated with a first light guide of the array of light guides. A first primer set is disposed throughout a first well region of each nanowell. A second primer set is disposed throughout a second well region of each nanowell. The second well region is adjacent the first well region. The first and second primer sets are operable to attach a forward strand cluster of forward polynucleotide strands in the first well region and a reverse strand cluster of reverse polynucleotide strands in the second well region.

公开(公告)号：US11747263B2

公开(公告)日：2023-09-05

申请号：US17811750

申请日：2022-07-11

Applicant: Illumina, Inc.

Inventor： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1429 ,  G01N2015/145

Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

公开(公告)号：US11385162B2

公开(公告)日：2022-07-12

申请号：US17148214

申请日：2021-01-13

Applicant: Illumina, Inc.

Inventor： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC: G01N15/14

Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

公开(公告)号：US10921233B2

公开(公告)日：2021-02-16

申请号：US16567224

申请日：2019-09-11

Applicant: Illumina, Inc.

Inventor： Arnaud Rival ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger ,  Poorya Sabounchi ,  Tarun Khurana ,  Craig M. Ciesla ,  M. Shane Bowen

IPC: G01N15/14

Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.