公开(公告)号：US07244826B1

公开(公告)日：2007-07-17

申请号：US09250056

申请日：1999-02-12

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/395

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US07045283B2

公开(公告)日：2006-05-16

申请号：US09981636

申请日：2001-10-16

Applicant: James D. Marks ,  Ulrik B. Nielson ,  Dimitri B. Kirpotin

Inventor： James D. Marks ,  Ulrik B. Nielson ,  Dimitri B. Kirpotin

IPC: C12Q1/00 ,  G01N33/53 ,  G01N33/566 ,  G01N33/573

CPC classification number: G01N33/5011 ,  C40B30/04 ,  G01N33/5008 ,  G01N33/5432 ,  G01N33/566 ,  G01N33/6845 ,  G01N33/6854 ,  G01N33/6863

Abstract: This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand; ii) dissociating the reporter from the ligand and removing dissociated reporter from the surface of the cell; and iii) detecting the reporter within said cell (if any is present) where the presence of the reporter within said cell indicates that the ligand binds to an internalizing receptor and is internalized.

公开(公告)号：US09220772B2

公开(公告)日：2015-12-29

申请号：US13810638

申请日：2011-07-22

Applicant: Yu Zhou ,  James D. Marks

Inventor： Yu Zhou ,  James D. Marks

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/46 ,  C07K16/28 ,  C07K16/40

CPC classification number: C07K16/2866 ,  A61K39/39558 ,  A61K47/60 ,  C07K16/2884 ,  C07K16/30 ,  C07K16/40 ,  C07K16/464 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibodies that bind to tumor associated antigen CD44 or to tumor associated antigen EphA2, are disclosed herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies, diagnostics, and screening methods.

Abstract translation: 与肿瘤相关抗原CD44或肿瘤相关抗原EphA2结合的抗体在本文中公开，以及相关的组合物和使用方法。 使用方法包括癌症治疗，诊断和筛选方法。

公开(公告)号：US08974792B2

公开(公告)日：2015-03-10

申请号：US13441651

申请日：2012-04-06

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: A61K39/44 ,  A61K39/395 ,  C07K16/30 ,  A61K47/48 ,  C07K16/28 ,  C07K16/32 ,  C12N15/86 ,  A61K31/704 ,  A61K38/00

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US08329873B2

公开(公告)日：2012-12-11

申请号：US11943367

申请日：2007-11-20

Applicant: Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

Inventor： Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

IPC: C07K16/00

CPC classification number: A61K39/395 ,  A61K51/109 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/622 ,  G01N2333/71

Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

Abstract translation: 公开了双特异性单链抗体分子，其可用于治疗与EGFR蛋白家族的成员的过表达相关的各种形式的癌症。

公开(公告)号：US08173424B2

公开(公告)日：2012-05-08

申请号：US12928792

申请日：2010-12-16

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: C12N5/16 ,  C07H21/02 ,  C07H21/04 ,  A61K39/395 ,  C12P21/08

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US20100297004A1

公开(公告)日：2010-11-25

申请号：US12676348

申请日：2008-09-04

Applicant: Anna M. Wu ,  Robert E. Reiter ,  Eric J. Lepin ,  James D. Marks ,  Yu Zhou

Inventor： Anna M. Wu ,  Robert E. Reiter ,  Eric J. Lepin ,  James D. Marks ,  Yu Zhou

IPC: A61K51/10 ,  C07K16/00 ,  C12N9/96 ,  C12N15/13 ,  C12N5/09 ,  A61K39/395 ,  A61K49/00 ,  A61B5/055 ,  A61P35/00

CPC classification number: C07K16/3069 ,  A61K39/39558 ,  A61K51/1096 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492

Abstract: The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis, prognosis, treatment, visualization, and the like. The present invention also provides methods for the detection, visualization, and treatment of various cancers expressing PSCA.

Abstract translation: 本发明提供结合癌抗原PSCA的新型高亲和力抗体及其片段。 本发明的抗体可用于癌症诊断，预后，治疗，可视化等。 本发明还提供了用于检测，可视化和治疗表达PSCA的各种癌症的方法。

公开(公告)号：US20100166773A1

公开(公告)日：2010-07-01

申请号：US12528601

申请日：2008-03-21

Applicant: James D. Marks ,  Isin N. Geren ,  Maria Consuelo Garcia ,  Jianlong Lou ,  Ali Razai

Inventor： James D. Marks ,  Isin N. Geren ,  Maria Consuelo Garcia ,  Jianlong Lou ,  Ali Razai

IPC: A61K39/40 ,  C07K16/12 ,  A61P31/04

CPC classification number: C07K16/40 ,  C07K16/1282 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并典型地中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US07483838B1

公开(公告)日：2009-01-27

申请号：US09556945

申请日：2000-04-21

Applicant: James D. Marks

Inventor： James D. Marks

IPC: G06Q10/00

CPC classification number: G06Q50/24 ,  G06F19/00 ,  G06F19/3418 ,  G06Q10/10 ,  G06Q50/22 ,  G16H10/20 ,  G16H10/60

Abstract: An on-line click wrap electronic agreement that a user must agree to prior to being registered as a volunteer and considered as a potential candidate in a clinical trial or research study. The agreement authorizes the release of the end user's medical and/or personal information to representatives of the clinical trials and research studies for which the volunteer may be considered as a potential candidate. After receiving the end user's consent to the click wrap agreement an electronic survey form is generated by a secure server and displayed at the end user's computer terminal. Responses by the end user to the survey form are kept secure as much as possible while being transmitted from the computer terminal across the network to the server and while stored and accessed only by authorized personnel at the central office.

Abstract translation: 一个在线点击包装电子协议，用户必须在注册为志愿者之前同意，并被认为是临床试验或研究研究中的潜在候选人。 该协议授权将最终用户的医疗和/或个人信息发布给临床试验和研究研究的代表，志愿者可被视为潜在候选人。 在收到最终用户同意点击包装协议之后，电子调查表由安全服务器生成，并显示在最终用户的计算机终端。 最终用户对调查表的响应在从计算机终端通过网络传输到服务器的同时尽可能地保持安全，并且仅在中心局的授权人员存储和访问。

公开(公告)号：US07472071B2

公开(公告)日：2008-12-30

申请号：US09447259

申请日：1999-11-23

Applicant: James D. Marks ,  Robert Weaver ,  Jeremy Shao

Inventor： James D. Marks ,  Robert Weaver ,  Jeremy Shao

IPC: G06F9/44

CPC classification number: G06Q10/10 ,  G06Q10/06311 ,  G06Q40/08 ,  G09B7/00

Abstract: A method, executed by a server, for providing answers on one or more topics from a set of experts on each topic to questions posed by users. Users can direct questions to one or more specific experts, who in turn can answer the questions, refer the questions to other experts, or both. The server automatically organizes and stores questions and answers in various fora. An administrator can take advantage of the design of the system to create or change a forum without having to write or change low-level code.

Abstract translation: 由服务器执行的用于从关于每个主题的一组专家提供关于用户提出的问题的一个或多个主题的答案的方法。 用户可以向一个或多个特定专家提出问题，反过来可以回答问题，将问题转交给其他专家或两者。 服务器自动组织和存储各种论坛的问题和答案。 管理员可以利用系统的设计来创建或更改论坛，而无需编写或更改低级代码。