公开(公告)号：US20110288469A1

公开(公告)日：2011-11-24

申请号：US13194612

申请日：2011-07-29

Applicant: John McIntyre ,  Elbert Tzeng

Inventor： John McIntyre ,  Elbert Tzeng

IPC: A61M37/00

CPC classification number: A61B17/3478 ,  A61B18/1477 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2018/00166 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/2005

Abstract: A surgical device is provided for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. A method is also provided for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent to the tissue, for example, for transmyocardial revascularization or other procedures.

Abstract translation: 提供外科装置用于消融患者组织中的通道并且还递送治疗剂。 该装置包括细长多腔管，细长组织消融组件和治疗剂递送组件。 治疗剂能够被输送到通道和/或周围组织中。 该装置还可以包括还能够递送治疗剂的第二多腔管。 还提供了一种使用这种手术装置来消融患者组织中的通道并且还将治疗剂递送至组织的方法，例如用于经心肌血运重建或其它手术。

公开(公告)号：US20100081619A1

公开(公告)日：2010-04-01

申请号：US12568400

申请日：2009-09-28

Applicant: William Tedford ,  John McIntyre ,  Daniel Russell ,  Peter Carlson

Inventor： William Tedford ,  John McIntyre ,  Daniel Russell ,  Peter Carlson

IPC: A01N37/18 ,  A01P7/04 ,  A01P7/00

CPC classification number: A01N25/02 ,  A01N37/18 ,  A01N37/46 ,  A01N63/02 ,  A61K38/1767 ,  C07K14/43518 ,  C07K14/43522 ,  A01N2300/00

Abstract: Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.

Abstract translation: 描述了使用溶剂来增加毒性昆虫肽的局部杀虫活性的方法。 这些方法包括如果需要，干燥肽，然后加入以下物质之一：1）有或者没有水的极性有机溶剂加入到干燥的肽中，或者2）向干燥的肽中加入极性非质子溶剂或其它佐剂 ，然后加入：1）有或无水的极性有机溶剂（其中首先加入极性非质子溶剂）或2）极性非质子溶剂或其它助剂加入到肽极性有机溶剂（其中极性有机溶剂 有机溶剂首先加入），制成肽。

公开(公告)号：US06863686B2

公开(公告)日：2005-03-08

申请号：US09912006

申请日：2001-07-24

Applicant: Donald Shannon ,  John McIntyre ,  Chris Kuo ,  Chris McCollam ,  Robert Peterson

Inventor： Donald Shannon ,  John McIntyre ,  Chris Kuo ,  Chris McCollam ,  Robert Peterson

IPC: A61F2/06 ,  B29D23/00 ,  B65B57/14 ,  B65G47/31

CPC classification number: B29D23/001 ,  A61F2/06 ,  B65B57/14 ,  B65G47/31 ,  Y10T428/1328 ,  Y10T428/1352

Abstract: A tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. The graft includes a base graft and a reinforcing tape applied thereto. The tape may be spirally wrapped about the graft or spirally wrapped into a tube about a cylindrical mandrel and then applied to the exterior of The graft. Radial shrinkage of the combined base graft and tape, or of the reinforcing tape tube, renders the vascular graft subsequently radially enlargeable by more than 5%, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.

Abstract translation: 由烧结的含氟聚合物形成的带状增强的管状血管移植物，例如膨胀的烧结PTFE。 移植物包括基底移植物和施加于其上的加强带。 胶带可以螺旋地缠绕在移植物周围或螺旋地缠绕在围绕圆柱形心轴的管中，然后施加到移植物的外部。 组合的基底移植物和带或增强带管的径向收缩使血管移植物随后径向放大超过5％，而不会撕裂或破坏移植物的加强带层。 本发明的可径向扩大的移植物可以与各种类型的支架或锚定系统组合，以形成血管内移植装置，其可平移插入并且可植入主体血管的腔内。 或者，本发明的径向可放大的移植物可以通过传统的手术移植物植入技术植入，而在植入时没有移植物的任何径向扩大，以便利用改进的强度性质和缝线保持性能 本发明的径向缩小的带状增强移植物。

公开(公告)号：US06790225B1

公开(公告)日：2004-09-14

申请号：US09358350

申请日：1999-07-21

Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

IPC: A61F206

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901 ,  C08L59/00

Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent. Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也被公开由支架移植物的各个部件预先组装在心轴上并随后被加热以便于PTFE层彼此和/或支架的附接。 可选地，支架移植物可以在从心轴移除之后进行后弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

公开(公告)号：US06781369B2

公开(公告)日：2004-08-24

申请号：US10361865

申请日：2003-02-11

Applicant: Peter O. Paulson ,  John McIntyre ,  Kevin Mitchell

Inventor： Peter O. Paulson ,  John McIntyre ,  Kevin Mitchell

IPC: G01N2782

CPC classification number: G01N27/82 ,  G01N27/902 ,  G01N33/383

Abstract: Discloses methods to perform magnetic testing of tensioning elements in a pre-stressed concrete cylinder, such as a pipe or water reservoir and testing apparatus. The apparatus includes magnetic flux production means and detector means disposed proximal to a surface of the cylinder in a plane in common with the magnetic flux production means that is orthogonal to an axis of the cylinder. The apparatus operates over a range of low frequency signals, for example, between 20 and 300 hertz or a pulse. Output of the inspection apparatus includes a signal and distance plot showing the results of testing a cylinder at one or more frequencies. In accordance with another method of analysis, a characteristic of the phase of the output over distance is plotted, including the phase or representations of the in-phase or quadrature components of the received signal in relation to the driving signal.

公开(公告)号：US6071307A

公开(公告)日：2000-06-06

申请号：US163831

申请日：1998-09-30

Applicant: Richard Rhee ,  John McIntyre ,  Seik Oh

Inventor： Richard Rhee ,  John McIntyre ,  Seik Oh

IPC: A61F2/84 ,  A61F2/04 ,  A61F2/06

CPC classification number: A61F2/07 ,  A61F2/95 ,  A61F2/89 ,  A61F2002/075 ,  A61F2250/001

Abstract: An endoluminal grafts is provided which is constructed to be radially collapsed and/or radially compressed to a small diameter. The graft has wireforms which generally comprise a wire deformed into generally annular configuration and consisting of a plurality of curvilinear wave forms. The wave forms have a plurality of first apices in linear alignment with each other, a plurality of second apices in linear alignment with each other, and a plurality of curvilinear segments traversing back and forth between said first and second apices. The graft is i) initially disposable in a radially compact configuration of a first diameter and ii) subsequently expandable to a radially expanded configuration of a second diameter, said second diameter being larger than said first diameter. When in its radially compact configuration, the adjacent curvilinear segments of the wireforms will nest or seat in abutting contact with one another, thereby minimizing the diameter of the graft while in its radially compact configuration.

Abstract translation: 提供了一种腔内移植物，其构造成径向塌缩和/或径向压缩至小直径。 移植物具有线形，其通常包括变形为大致环形构型并由多个曲线波形组成的线。 波形具有彼此线性对准的多个第一顶点，彼此线性对齐的多个第二顶点和在所述第一和第二顶点之间往复运动的多个曲线段。 移植物是i）最初一次性处于第一直径的径向致密构造中，并且ii）随后可扩张至第二直径的径向扩张构型，所述第二直径大于所述第一直径。 当处于其径向紧凑的构造中，线形的相邻曲线段将彼此嵌套或抵靠接触，从而使其在径向紧凑的构型中最小化移植物的直径。

公开(公告)号：US5833707A

公开(公告)日：1998-11-10

申请号：US498506

申请日：1995-07-05

Applicant: John McIntyre ,  Geoffrey A. Orth ,  Peter S. Brown

Inventor： John McIntyre ,  Geoffrey A. Orth ,  Peter S. Brown

IPC: A61F2/00 ,  A61F2/92 ,  A61M29/00

CPC classification number: A61F2/962 ,  A61F2/92 ,  A61F2002/9511 ,  A61F2210/0019 ,  A61F2220/0075

Abstract: An apparatus and method for temporarily implanting an intraluminal stent in a body lumen and its subsequent removal. A stent is formed from a thin sheet that has been wound around itself into a generally cylindrical roll. The stent has a deployed configuration with a deployed diameter generally the size of the lumen diameter. The stent has a delivery configuration, formed by winding the stent more tightly than the deployed configuration, with the delivery diameter smaller than the deployed diameter in order to allow low profile delivery into the body lumen. The stent will transform from the delivery configuration to the deployed configuration when exposed to body heat. The stent can be deployed by an intraluminal delivery catheter that secures the stent in its delivery configuration during intraluminal delivery of the stent. The stent can be removed from the body lumen via a removal catheter that coils the stent into a sheath at the end of the removal catheter.

Abstract translation: 一种用于临时植入管腔内支架在体腔中并随后移除的装置和方法。 支架由已经自身缠绕成大致圆柱形的卷的薄片形成。 支架具有展开的直径通常为管腔直径的尺寸的展开构造。 支架具有通过比展开构造更紧密地缠绕支架而形成的输送构造，其中输送直径小于展开直径，以便允许低调输送到体腔。 当暴露于体热时，支架将从输送配置转变为展开配置。 支架可以通过管腔内输送导管部署，其在支架的腔内递送期间将支架固定在其输送构造中。 支架可以通过去除导管从体腔去除，该导管将支架线圈在移除导管末端的护套中。

公开(公告)号：US4909289A

公开(公告)日：1990-03-20

申请号：US73279

申请日：1987-07-02

Applicant: Richard J. Hagan ,  John McIntyre ,  Michael Clausen

Inventor： Richard J. Hagan ,  John McIntyre ,  Michael Clausen

IPC: B67C3/06 ,  B67D1/04 ,  B67D1/08

CPC classification number: B67D1/0832 ,  Y10T137/5762 ,  Y10T137/6137

Abstract: A valve (20) has a valve housing (22) with a central passage (28) extending axially through the valve housing (22). Aperture (40) in the valve housing connect a second passage (38) to the central passage (28) to extend through the valve housing. A poppet valve member (24) is configured for sealing engagement of the central passage (28). The valve member (24) is urged into sealing engagement with the central passage (28) by internal pressure in a container (36) on which the valve (20) is provided. The valve member (24) and the valve housing (22) are configured so that the valve member (24) will drop away from sealing the central passage (28) when the pressure in the container (36) is insufficient to hold the valve member (24) in sealing position against the central passage (28) to leave the valve (20) in a permanently open state. An annular valve member (26) seals the second passage (38 ) in the same manner.

公开(公告)号：USD302525S

公开(公告)日：1989-08-01

申请号：US14681

申请日：1986-04-10

Applicant: Richard J. Hagan ,  John McIntyre ,  Kevin Reeder

Designer： Richard J. Hagan ,  John McIntyre ,  Kevin Reeder

公开(公告)号：US4646781A

公开(公告)日：1987-03-03

申请号：US873439

申请日：1986-06-05

Applicant: John McIntyre ,  Lanny A. Gorton

Inventor： John McIntyre ,  Lanny A. Gorton

IPC: A61M39/24 ,  F16K15/14

CPC classification number: A61M39/24 ,  A61M2039/2433 ,  A61M2039/246 ,  A61M2039/2466 ,  Y10T137/7843 ,  Y10T137/7895

Abstract: A valve, suitable for use in small medical devices and which can readily be made of medical grade materials, comprises an elastic diaphragm stretched over a protruding surface, preferably of spherical or convex shape. The diaphragm has a ring of holes concentrically around a hole in the protruding surface. A mating recess, connected to a conduit, fits over the protruding surface. The elastic material is held in place at or near the opening of the recess. The holding structure may also serve to seal the valve. A dual arrangement provides an input and an output valve in combination.

Abstract translation: 一种适用于小型医疗装置并且可以容易地由医疗级材料制成的阀，包括在突出表面上延伸的优选为球形或凸形形状的弹性隔膜。 隔膜具有围绕突出表面的孔同心的孔的环。 连接到导管的配合凹槽配合在突出表面上。 弹性材料在凹部的开口处或附近保持就位。 保持结构还可以用于密封阀。 双重布置组合地提供输入和输出阀。