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    Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output
    21.
    发明授权
    Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output 有权
    方法连续，非侵入性地监测肺毛细血管血流量和心输出量

    公开(公告)号：US06217524B1

    公开(公告)日：2001-04-17

    申请号：US09150446

    申请日：1998-09-09

    申请人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

    发明人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

    IPC分类号： A61B502

    CPC分类号： A61B5/0836 ,  A61M16/021 ,  A61M2016/0036 ,  A61M2016/103

    摘要： A method of continuously, non-invasively determining the cardiac output of a patient. The method includes intermittently measuring the cardiac output, the volume of carbon dioxide exhaled by the patient per breath, and determining the arterial-venous gradient of the patient or a similar substantially constant value by dividing the volume of carbon dioxide exhaled by the measured cardiac output. The arterial-venous gradient or similar substantially constant value may then be employed to determine the cardiac output of the patient on a breath-by-breath basis. The carbon dioxide elimination, which is non-invasively measured as the volume of carbon dioxide exhaled by the patient per breath, is divided by the arterial-venous gradient or the substantially constant value to determine the cardiac output. The method may also include generating a signal to compensate for any non-metabolic changes in the carbon dioxide elimination, arterial-venous gradient, or other respiratory or blood gas profile measurements that may be caused by a change in ventilation or breathing of the patient. The compensatory signal may be employed to modify one or more of the respiratory or blood gas profile measurements in order to facilitate the accurate determination of cardiac output during or after changes in ventilation or breathing.

    摘要翻译： 一种连续，非侵入性地确定患者的心输出量的方法。 该方法包括间歇地测量心输出量，每次呼吸患者呼出的二氧化碳的体积，以及通过将所测量的心输出量呼出的二氧化碳的体积除以来确定患者的动脉 - 静脉梯度或类似的基本上恒定的值 。 然后可以采用动脉 - 静脉梯度或类似的基本上恒定的值来确定患者在呼吸基础上的心输出量。 二氧化碳消除，其被非侵入性地测量为每个呼吸患者呼出的二氧化碳的体积，除以动脉 - 静脉梯度或基本上恒定的值以确定心输出量。 该方法还可以包括产生信号以补偿二氧化碳消除，动脉 - 静脉梯度或可能由患者的通气或呼吸改变引起的其它呼吸或血气分布测量中的任何非代谢变化。 补偿信号可以用于修改呼吸或血气剖面测量中的一个或多个，以便于在通气或呼吸改变期间或之后准确确定心输出量。

    Differential pressure sensor for respiratory monitoring
    22.
    发明授权
    Differential pressure sensor for respiratory monitoring 失效
    差压传感器用于呼吸监测

    公开(公告)号：US5535633A

    公开(公告)日：1996-07-16

    申请号：US287665

    申请日：1994-08-09

    申请人： Scott A. Kofoed ,  Joseph A. Orr

    发明人： Scott A. Kofoed ,  Joseph A. Orr

    IPC分类号： A61B5/08 ,  A61B5/087 ,  G01F1/36 ,  G01F1/40 ,  G01F1/46 ,  G01F1/50

    CPC分类号： G01F1/363 ,  A61B5/087 ,  G01F1/40 ,  G01F1/46 ,  G01F1/50

    摘要： A differential pressure sensor for measuring respiratory gas flow including a tubular housing having a bore containing a diametrically-oriented, longitudinally extending strut containing first and second lumens having longitudinally spaced pressure ports at axially spaced locations of the strut, the ports being located on opposite sides of a bore restriction.

    摘要翻译： 一种用于测量呼吸气流的差压传感器，包括管状壳体，所述管状壳体具有包含径向定向的纵向延伸的支柱的孔，所述支柱包含第一和第二腔，所述第一和第二腔在所述支柱的轴向间隔开的位置处具有纵向隔开的压力端口，所述端口位于相对侧 的钻孔限制。

    Ultrasound medical diagnostic device having a coupling medium providing self-adherence to a patient
    23.
    发明授权
    Ultrasound medical diagnostic device having a coupling medium providing self-adherence to a patient 失效
    超声医疗诊断装置具有提供对患者的自身粘附的耦合介质

    公开(公告)号：US5394877A

    公开(公告)日：1995-03-07

    申请号：US216079

    申请日：1994-03-21

    申请人： Joseph A. Orr ,  Dwayne R. Westenskow ,  Fidel H. Silva

    发明人： Joseph A. Orr ,  Dwayne R. Westenskow ,  Fidel H. Silva

    IPC分类号： A61B5/0408 ,  A61B8/00 ,  A61B8/02 ,  A61B19/08

    CPC分类号： A61B8/4281 ,  A61B5/0408 ,  A61B8/02 ,  A61B8/0866 ,  A61B8/4236 ,  A61B8/4455 ,  A61B2046/205

    摘要： A contact medium structure attachable to externally-applied medical diagnostic devices for providing self-adherence of the medical device to the skin of a patient thereby eliminating the need for belts or similar means. The contact medium is inherently adhesive, hydrophilic, skin-compatible, ultrasonic-compatible and pressure sensitive to facilitate self-adhesion of the medical device to the patient's skin. A particularly suitable contact medium is a mesh-reinforced hydrogel film which adheres to the device and extends beyond the perimeter of the device to provide additional adhesiveness and compliance with the contour of the patient's body. A support element associated with and extending beyond the perimeter of the medical device adheres to the contact medium and provides adjustability of the extended hydrogel film relative to the patient's skin.

    摘要翻译： 接触介质结构，其可附接到外部应用的医疗诊断装置，用于提供医疗装置对患者皮肤的自身粘附，从而消除对皮带或类似装置的需要。 接触介质固有地具有粘合性，亲水性，皮肤相容性，超声波兼容性和压力敏感性，以促进医疗装置对患者皮肤的自粘附。 特别合适的接触介质是网状增强的水凝胶膜，其粘附到装置并延伸超过装置的周边，以提供额外的粘附性并且与患者身体的轮廓一致。 与医疗装置的周边相关联并且延伸超过医疗装置周边的支撑元件粘附于接触介质并提供延伸的水凝胶膜相对于患者皮肤的可调节性。

    Method and apparatus for monitoring neuromuscular blockage
    24.
    发明授权
    Method and apparatus for monitoring neuromuscular blockage 失效
    监测神经肌肉阻塞的方法和装置

    公开(公告)号：US5131401A

    公开(公告)日：1992-07-21

    申请号：US580294

    申请日：1990-09-10

    申请人： Dwayne R. Westenskow ,  Joseph A. Orr

    发明人： Dwayne R. Westenskow ,  Joseph A. Orr

    IPC分类号： A61B5/0488 ,  A61B5/11 ,  A61B5/22 ,  A61B10/00 ,  A61M16/01

    CPC分类号： A61B5/1106 ,  A61B5/7207 ,  A61B2562/0219 ,  A61B5/6825 ,  A61B5/7217

    摘要： The present invention comprises a method and apparatus for monitoring neuromuscular blockage, and more specifically contemplates the quantitative measurement of movement of the skin of a patient overlying an electrically simulated skeletal muscle as an indicia of such blockage. The preferred embodiment of the apparatus of the present invention includes a piezoelectric film affixed over the patient's skin, the film generating an electric current in proportion to the magnitude of skin movement.

    摘要翻译： 本发明包括用于监测神经肌肉阻塞的方法和装置，并且更具体地考虑对作为这种阻塞的标记的覆盖在电动模拟骨骼肌上的患者的皮肤的运动的定量测量。 本发明的装置的优选实施例包括固定在患者皮肤上的压电膜，所述膜产生与皮肤运动的大小成比例的电流。

    Formable reusable enclosure
    25.
    发明授权
    Formable reusable enclosure 失效
    可重复使用的外壳

    公开(公告)号：US5102036A

    公开(公告)日：1992-04-07

    申请号：US540571

    申请日：1990-06-19

    申请人： Joseph A. Orr ,  John R. Orr

    发明人： Joseph A. Orr ,  John R. Orr

    IPC分类号： B65D59/04

    CPC分类号： B65D59/04 ,  Y02W30/807 ,  Y10S220/903

    摘要： A formable reusable enclosure is disclosed for use as a container wrap, a mailing tube, or the like. One specific embodiment of the enclosure comprises a pliable, elongated, substantially rectangular panel member having opposing ends and a tongue portion extending from one of the opposed ends. The panel member has an outer layer of bendable kraft board and an inner layer of corrugated paper adhered to the kraft board. The panel member is adapted to be formed into an enclosure by bending the panel member into the configuration of the peripheral wall of a container with the tongue portion overlapping the opposing end of the panel member. A slot is formed through the panel member adjacent to the end which is opposite to the tongue portion end. The slot has an engagement edge aligned parallel to the corrugations in the inner paper layer, enabling adjustment of the size of the enclosure by selecting a desired corrugation for engagement with the slot edge. The selected corrugation locks against the engagement edge when the tongue portion is inclined at an acute angle with respect to the outer kraft paper layer, thereby preventing the tongue portion form withdrawing from the slot.

    摘要翻译： 一种可成形的可重复使用的外壳被公开用作容器包装，邮寄管等。 外壳的一个具体实施例包括柔韧的，细长的基本上矩形的面板构件，其具有相对的端部和从相对的一个中的一个延伸的舌部。 面板构件具有可弯曲的牛皮纸板的外层和粘附到硫酸盐板的瓦楞纸的内层。 面板构件适于通过将面板构件弯曲成容器的周壁的构造而形成为外壳，其中舌部与面板构件的相对端重叠。 通过与舌部相对的端部相邻的面板构件形成槽。 狭槽具有与内纸层中的波纹平行排列的接合边缘，能够通过选择用于与槽边缘接合的所需波纹来调节外壳的尺寸。 当舌部相对于外部牛皮纸层倾斜成锐角时，所选择的波纹锁定在接合边缘上，从而防止舌部从槽中退出。

    Method for reducing the effects of general anesthetics
    27.
    发明授权
    Method for reducing the effects of general anesthetics 有权
    降低全身麻醉效果的方法

    公开(公告)号：US07891356B2

    公开(公告)日：2011-02-22

    申请号：US11843994

    申请日：2007-08-23

    申请人： Joseph A. Orr ,  Dwayne R. Westenskow

    发明人： Joseph A. Orr ,  Dwayne R. Westenskow

    IPC分类号： A61M11/00

    CPC分类号： A61M16/009 ,  A61M16/0045 ,  A61M16/0093 ,  A61M16/0833 ,  A61M16/085 ,  A61M16/0891 ,  A61M16/105 ,  A61M16/1055 ,  A61M16/106 ,  A61M16/22

    摘要： An apparatus for reversing inhaled anesthesia, which is configured to be positioned along a breathing circuit or anesthesia delivery circuit, includes a filter for removing one or more anesthetic agents from gases passing therethrough, as well as a component for elevating CO2 levels in gases that are to be inhaled by an individual. The apparatus is configured to be positioned between a Y-connector of the breathing circuit and the portion of the breathing circuit that interfaces with the individual. The CO2 level-elevating component facilitates an increase in the ventilation of the individual without resulting in a significant decrease in the individual's PaCO2 level and, thus, a decrease in the rate at which blood flows through the individual's brain. A method of reversing the effects of inhaled anesthesia includes increasing the rate of ventilation of an anesthetized individual while causing the individual to inhale gases with elevated amounts of CO2 and while filtering anesthetic agents from such gases.

    摘要翻译： 用于反转吸入麻醉的装置，其被配置为沿着呼吸回路或麻醉输送回路定位，包括用于从通过其中的气体中去除一种或多种麻醉剂的过滤器，以及用于提高气体中的CO 2水平的组分， 被个人吸入。 该装置构造成位于呼吸回路的Y形连接器和与个体接触的部分呼吸回路之间。 二氧化碳水平升高组件有助于个体的通气量增加，而不会导致个体PaCO2水平的显着降低，从而导致血液流过个体大脑的速度降低。 一种逆转吸入麻醉效果的方法包括增加麻醉个体的通气率，同时使个体以较高量的CO 2吸入气体，同时从这些气体中过滤麻醉剂。

    Apparatus and method for non-invasively measuring cardiac output
    30.
    发明授权
    Apparatus and method for non-invasively measuring cardiac output 有权
    非侵入性测量心输出量的装置和方法

    公开(公告)号：US06648831B2

    公开(公告)日：2003-11-18

    申请号：US09767363

    申请日：2001-01-23

    申请人： Joseph A. Orr ,  Scott A. Kofoed ,  Dwayne Westenskow ,  Michael B. Jaffe

    发明人： Joseph A. Orr ,  Scott A. Kofoed ,  Dwayne Westenskow ,  Michael B. Jaffe

    IPC分类号： A61B0500

    CPC分类号： A61B5/029 ,  A61B5/0836 ,  A61M16/0045 ,  A61M16/0833 ,  A61M2016/0036 ,  A61M2230/432 ,  G01N33/004 ,  Y02A50/243

    摘要： Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.

    摘要翻译： 公开了使用部分再呼吸技术非侵入性地确定心输出量的装置和方法，其中该装置构造有瞬时可调的死区，以适应各种患者的呼吸能力差异。 该设备由便宜的元件构成，包括单个双向阀，其使得该设备使用起来非常简单且便宜，使得该单元可以容易地被一次性使用。 本发明的方法提供了一种基于肺泡二氧化碳值估计心输出量的新方法，而不是如先前所述的潮汐CO 2值。 还公开了一种用于计算心输出量的程序。