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公开(公告)号:US20120238571A1
公开(公告)日:2012-09-20
申请号:US13513079
申请日:2010-12-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
IPC分类号: C07D417/14 , A61K31/437 , A61K31/4439 , A61K31/427 , C07D413/14 , C07D471/04 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P35/00 , A61P15/00 , A61P41/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P9/10 , A61K31/5377
CPC分类号: C07D417/14 , C07D417/12 , C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20120238559A1
公开(公告)日:2012-09-20
申请号:US13513048
申请日:2010-12-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4439 , A61P37/08 , A61P37/06 , A61P29/00 , A61P9/00 , A61P25/28 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/00 , A61P9/10 , A61P19/02 , A61P11/06 , C07D401/14 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/422 , C07D403/14 , A61K31/416 , C07D417/14 , A61K31/427 , C07D491/048 , A61K31/4355 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61P11/00
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20110178063A1
公开(公告)日:2011-07-21
申请号:US12994250
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/553 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/5386 , C07D401/14 , A61K31/454 , A61K31/427 , A61K31/496 , A61K31/4439 , C07D471/04 , A61K31/4985 , C07D487/04 , A61K31/519 , A61P11/00 , A61P37/08 , A61P9/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P7/02 , A61P29/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新的式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US08658635B2
公开(公告)日:2014-02-25
申请号:US12994250
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/501 , A61K31/496 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/4523 , A61K31/4427 , A61K31/427 , A61K31/425 , C07D267/02 , C07D279/12 , C07D295/00 , C07D265/30 , C07D413/14 , C07D487/12 , C07D417/12 , C07D211/00 , C07D277/20 , C07D235/00 , C07D233/54 , C07D403/14
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新的式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20110118246A1
公开(公告)日:2011-05-19
申请号:US12994253
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4439 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D405/14 , C07D471/04 , A61K31/4985 , A61K31/444 , C07D417/14 , A61K31/541 , A61P11/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P37/06 , A61P29/00 , A61P9/10
CPC分类号: C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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26.4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES 有权
标题翻译: 用作P13-激酶抑制剂的4-羧酰胺吲哚衍生物公开(公告)号:US20110112070A1
公开(公告)日:2011-05-12
申请号:US12994246
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: A61K31/416 , C07D401/12 , C07D231/56 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/4439 , A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/541 , A61K31/553 , A61P11/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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公开(公告)号:US08536169B2
公开(公告)日:2013-09-17
申请号:US12994254
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/5377 , A61K31/416 , A61K31/454 , A61K31/4439 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及针对式(I)化合物及其盐的某些新化合物。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20060189632A1
公开(公告)日:2006-08-24
申请号:US10547080
申请日:2004-03-01
申请人: Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Mitchell , James Simpson , John Harris , Joelle Le
发明人: Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Mitchell , James Simpson , John Harris , Joelle Le
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.
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公开(公告)号:US07667036B2
公开(公告)日:2010-02-23
申请号:US11202035
申请日:2005-08-12
申请人: Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Kenichiro Kataoka , Dale Robert Mitchell , Donald James Simpson , Clifford John Harris , Joelle Le , Yuko Yamakoshi
发明人: Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Kenichiro Kataoka , Dale Robert Mitchell , Donald James Simpson , Clifford John Harris , Joelle Le , Yuko Yamakoshi
IPC分类号: C07D487/04 , A61K31/519 , A61P35/04 , A61P25/28
CPC分类号: C07D487/04
摘要: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.
摘要翻译: 由式I表示的吡唑并[1,5-a]嘧啶衍生物及其药学上可接受的盐表现出优异的MAPKAP-K2抑制活性。 因此,包含化合物作为有效成分的药物预期可用作MAPKAP-K2介导的病症如炎性疾病,自身免疫性疾病,破坏性骨病,癌症和/或肿瘤生长的治疗或预防剂。
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公开(公告)号:US07557110B2
公开(公告)日:2009-07-07
申请号:US10547080
申请日:2004-03-01
申请人: Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Dale Mitchell , James Donald Simpson , John Clifford Harris , Joelle Le
发明人: Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Dale Mitchell , James Donald Simpson , John Clifford Harris , Joelle Le
IPC分类号: C07D487/04 , A61K31/519
CPC分类号: C07D487/04
摘要: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.
摘要翻译: 由式I表示的吡唑并[1,5-a]嘧啶衍生物及其药学上可接受的盐表现出优异的激酶抑制活性。 因此,包含化合物作为有效成分的药物预期可用作其中涉及激酶的蛋白激酶介导的病症的治疗或预防剂,例如炎性疾病,自身免疫疾病,破坏性骨病,癌症和/或肿瘤生长。
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