摘要:
The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost.According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim 1).
摘要:
This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.
摘要:
A clock diagnosis circuit includes: a delay circuit to delay the clock by a prescribed time which is not more than the clock pulse width; an integral multiplication delay circuit to delay a delayed clock outputted from the delay circuit by a prescribed number of cycles; a first exclusive OR circuit to encode the clock using the delayed clock; a second exclusive OR circuit to decode an output of the first exclusive OR circuit using an output of the integral multiplication delay circuit; and a comparison circuit to compare the clock with an output of the second exclusive OR circuit to thereby detect a malfunction of the clock.
摘要:
When a transaction layer circuit detects an error, error information in respect of transmission data is set in a TLP digest. The method includes: a step in which, at an endpoint (3a) that receives a memory read request transmitted by the root complex 1, if an error is detected during transmission of first data corresponding to the requested TLP, error information is set in the TLP digest and a completion with data attached is returned; a step in which the root complex (1) returns a memory read request based on the error information to the endpoint; a step in which the endpoint returns requested second data; and a step in which the root complex terminates the response after overwriting the error location of the first data that was held, with the second data.
摘要:
A microprocessor operation monitoring system whose own tasks are constituted by associating beforehand the task number of the task that is next to be started up, for each of the tasks constituting the program, and abnormality of microprocessor operation is detected by comparing and determining whether or not the announced task and the task to be started up match.
摘要:
A first arithmetic operator (11) includes a first modular arithmetic coding encoder (11b) for encoding a numeric data transmitted by a command from a central controller (31) into a modular arithmetic code, a first arithmetic operation processor (11a) using the numeric data as modular arithmetic coded as an input operand, for executing an arithmetic operation based on a command from the central controller (13), to provide an output in the form of a modular arithmetic code, and a first modular arithmetic code decoder (11c) for determining presence or absence of a bit error in the numeric data output from the first arithmetic operation processor, correcting the bit error, if detected any, to output a decoded numeric data.
摘要:
A transmission system which performs protections to node failures by using protection paths equipped by a shared node protection system for each transmission path on a network formed of a plurality of nodes, uniformly moving transmission band setting of all other protection paths which share these transmission bands when the transmission bands on the network are occupied by the protections.
摘要:
A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.
摘要:
A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino-protected aspartic anhydride represented by the formula (1) with a primary amine represented by the formula R′NH2, subjecting the reaction product to cyclodehydration to obtain an optically active 1-aralkyl-3-(protected amino)pyrrolidine-2,5-dione compound represented by the formula (2), subsequently eliminating the protective group from the 3-position amino group of the compound represented by the formula (2) to obtain an optically active 1-aralkyl-3-aminopyrrolidine-2,5-dione compound represented by the formula (3), reducing the carbonyl groups of the compound represented by the formula (3) to obtain either an optically active 1-aralkyl-3-aminopyrrolidine compound represented by the formula (4) or a salt thereof with a protonic acid, and then subjecting the compound represented by the formula (4) or the salt thereof to hydrogenolysis to obtain an optically active 1H-3-aminopyrrolidine or a protonic acid salt thereof.