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公开(公告)号：US06747059B1
公开(公告)日：2004-06-08
申请号：US09459171
申请日：1999-12-10
IPC分类号： A61K31352
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： Cocoa extracts which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. The liquid or dry cocoa extracts can be included in foods, food supplements and pharmaceuticals for the inhibition of COX activity, the inhibition of LOX activity, the enhancement of nitric oxide production, the modulation of eicosanoids and endothelin, and the modulation of platelet activity.
摘要翻译： 包括原花青素单体及其低聚物的可可提取物可用于调节炎症途径，维持哺乳动物的血管健康和作为抗菌治疗。 液体或干可可提取物可以包括在食品，食品添加剂和药物中，用于抑制COX活性，抑制LOX活性，增强一氧化氮产生，类花生酸和内皮素的调节以及血小板活性的调节。
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公开(公告)号：US06696485B1
公开(公告)日：2004-02-24
申请号：US10268718
申请日：2002-10-10
IPC分类号： A61K31353
CPC分类号： C07H17/06 , A61K9/2068 , A61K31/353 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , A61K2300/00
摘要： This invention relates to compositions comprising a cyclo-oxygenase modulator in combination with cocoa procyanidin monomers and/or oligomers, wherein the cyclo-oxygenase modulator is a non-steroidal anti-inflammatory drug such as aspirin. Such compositions may be used for the treatment of cardiovascular related disorders.
摘要翻译： 本发明涉及包含与可可原花青素单体和/或低聚物组合的环加氧酶调节剂的组合物，其中环加氧酶调节剂是非甾体抗炎药物，例如阿司匹林。 这样的组合物可用于治疗心血管相关疾病。
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23.发明授权公开(公告)号：US06469053B1
公开(公告)日：2002-10-22
申请号：US09507717
申请日：2000-02-18
IPC分类号： A61K31353
CPC分类号： A61K36/185 , A61K9/2068 , A61K31/353 , C07D311/62 , C07H17/06
摘要： Cocoa extracts which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. The liquid or dry cocoa extracts can be included in foods, food supplements and pharmaceuticals for the inhibition of COX activity, the inhibition of LOX activity, the enhancement of nitric oxide production, the modulation of eicosanoids and endothelin, and the modulation of platelet activity.
摘要翻译： 包括原花青素单体及其低聚物的可可提取物可用于调节炎症途径，维持哺乳动物的血管健康和作为抗菌治疗。 液体或干可可提取物可以包括在食品，食品添加剂和药物中，用于抑制COX活性，抑制LOX活性，增强一氧化氮产生，类花生酸和内皮素的调节以及血小板活性的调节。
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公开(公告)号：US08377424B2
公开(公告)日：2013-02-19
申请号：US11004677
申请日：2004-12-03
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： This invention relates to a method of therapeutic or prophylactic treatment of periodontal disease comprising administering to a subject in need thereof a polymeric compound of formula An. Also disclosed and claimed is an article of manufacture comprising the above compounds packaged within a container with instructions for use, and methods of making thereof.
摘要翻译： 本发明涉及治疗性或预防性治疗牙周疾病的方法，包括向需要的受试者施用式A的聚合物。 还公开并要求保护的是包含包装在具有使用说明书的容器内的上述化合物的制品及其制备方法。
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公开(公告)号：US07115656B2
公开(公告)日：2006-10-03
申请号：US10780298
申请日：2004-02-17
IPC分类号： A61K31/352
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： This invention discloses methods of anti-platelet therapy or prophylaxis comprising administering to a subject in need thereof a composition comprising an effective amount of a procyanidin oligomer or a derivative thereof.
摘要翻译： 本发明公开了抗血小板治疗或预防方法，包括向有需要的受试者施用包含有效量的原花青素低聚物或其衍生物的组合物。
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公开(公告)号：US06900241B2
公开(公告)日：2005-05-31
申请号：US10770969
申请日：2004-05-06
IPC分类号： A23G1/32 , A23G3/36 , A23K1/16 , A23K1/18 , A61K9/20 , A61K9/48 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C07H17/06 , C11B5/00 , C07D311/78
CPC分类号： C07H17/06 , A23G1/32 , A23G3/36 , A23K20/111 , A23K50/40 , A61K9/2018 , A61K9/2068 , A61K9/4858 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K45/06 , C07D311/32 , C07D311/62 , C07D311/64 , C11B5/0035 , A61K2300/00
摘要： Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R, X, Y and Z are as defined in the specification.
摘要翻译： 公开并要求保护的是可可提取物，化合物，其组合和含有它们的组合物，例如多酚或原花青素，制备此类提取物的方法，化合物和组合物，以及它们的用途，特别是式A的< 其中A是下式的单体：其中n是2至18的整数，使得存在至少一个末端单体单元A和一个或多个另外的单体单元; R，X，Y和Z如说明书中所定义。
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27.发明授权公开(公告)号：US06207702B1
公开(公告)日：2001-03-27
申请号：US09441644
申请日：1999-11-17
IPC分类号： A61K3135
CPC分类号： A23G1/30 , A23G1/426 , A61K31/353 , Y10S426/804
摘要： A method for reducing postprandial oxidative stress and associated pathologies by the dietary intake of cocoa procyanidins, such as epicatechin is disclosed.
摘要翻译： 公开了通过膳食摄入可可原花青素（如表儿茶素）减少餐后氧化应激和相关病理学的方法。
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公开(公告)号：US20110257118A1
公开(公告)日：2011-10-20
申请号：US13168853
申请日：2011-06-24
IPC分类号： A61K31/353 , A61P9/00 , B65D85/00 , A61K31/7048
CPC分类号： A61K31/353 , A61K31/35 , A61K31/70
摘要： The invention relates to compositions, and methods of use thereof, containing polyphenols such as flavanols, procyanidins, their derivatives and epimers thereof, for improving vascular circulation in peripheral and/or small blood vessels.
摘要翻译： 本发明涉及包含多酚如黄烷醇，原花青素，其衍生物和差向异构体的组合物及其使用方法，用于改善外周和/或小血管中的血管循环。
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公开(公告)号：US09675630B2
公开(公告)日：2017-06-13
申请号：US11045648
申请日：2005-01-28
IPC分类号： A61K31/353 , A61K31/7048
CPC分类号： A61K31/7048 , A23G2200/04 , A61K31/353
摘要： The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing A-type procyanidins, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent NO-responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease and/or vascular circulation disorders, prevent or reduce the risk of heart attack, stroke, congestive heart failure and/or kidney failure, or to improve blood flow, for example renal blood flow. The composition may optionally contain an additional NO modulating agent and/or a cardiovascular-protective or therapeutic agent, or may be administered in combination with such an agent.
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公开(公告)号：US06610320B2
公开(公告)日：2003-08-26
申请号：US09829782
申请日：2001-04-10
IPC分类号： A61K3578
CPC分类号： A23G1/30 , A23G1/426 , A23G1/48 , A23G1/56 , A23G3/36 , A23G3/48 , A23G2200/04 , A23K20/10 , A23K20/111 , A23K20/116 , A23K20/121 , A23K20/168 , A23K50/00 , A23K50/40 , A23L2/52 , A23L33/105 , A23L33/11 , A23L33/21 , A23V2002/00 , A61K36/185 , A61K36/48 , A61K2300/00 , A23V2250/2104 , A23V2250/5488 , A23V2250/0606 , A23V2250/70 , A23V2250/156 , A23V2250/2136 , A23V2250/21368 , A23V2250/2132 , A23V2250/1882 , A23V2250/506
摘要： This invention relates to compositions containing polyphenols, for example, cocoa polyphenols such as procyanidins, in combination with at least one cholesterol lowering agent, and methods for improving vascular health including treating and preventing atherosclerosis and cardiovascular disease.
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