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    Method and apparatus for cardiac defibrillation
    21.
    发明授权
    Method and apparatus for cardiac defibrillation 有权
    用于心脏除颤的方法和装置

    公开(公告)号：US06647291B1

    公开(公告)日：2003-11-11

    申请号：US09540136

    申请日：2000-03-31

    申请人： Matthew D. Bonner ,  Rahul Mehra

    发明人： Matthew D. Bonner ,  Rahul Mehra

    IPC分类号： A61N118

    CPC分类号： A61N1/0563 ,  A61N2001/0585

    摘要： A method for cardioverting or defibrillating a human heart, performed by placing a transvenous lead having a cardioversion or defibrillation electrode such that the electrode is located at least partially within the middle cardiac vein of a patient's heart and placing an additional cardioversion or defibrillation electrode in the superior vena cava of the patient's heart and thereafter delivering a cardioversion or defibrillation pulse between the first and second electrodes. The method may be practiced by placing the transvenous such that the defibrillation electrode it carries extends around the apex of the patient's heart, and the transvenous lead may be advanced through one cardiac vein toward the apex of the patient's heart and thereafter advanced upward through a different cardiac vein.

    摘要翻译： 通过放置具有心脏复律或除颤电极的经静脉导管使得电极至少部分位于患者心脏的中心静脉内并将另外的心脏复律或除颤电极放置在心脏复律或除颤电极中来进行心脏转复或除纤维化的方法 患者心脏的上腔静脉，然后在第一和第二电极之间递送心脏复律或除颤脉冲。 该方法可以通过放置静脉使得其携带的除颤电极围绕患者心脏的顶点延伸，并且经静脉导管可以通过一个心静脉前进到患者心脏的顶点，然后向上通过不同的 心脏静脉

    Introducer system
    22.
    发明授权
    Introducer system 有权
    介绍系统

    公开(公告)号：US06379346B1

    公开(公告)日：2002-04-30

    申请号：US09552250

    申请日：2000-04-18

    申请人： Michael E. McIvor ,  Kenneth C. Gardeski ,  Pedro A. Meregotte ,  Matthew D. Bonner ,  Timothy G. Laske ,  Linda L. Lach

    发明人： Michael E. McIvor ,  Kenneth C. Gardeski ,  Pedro A. Meregotte ,  Matthew D. Bonner ,  Timothy G. Laske ,  Linda L. Lach

    IPC分类号： A61M2500

    CPC分类号： A61M25/0668 ,  A61M25/01 ,  A61M2025/0675

    摘要： An introducer is structured with an elongated tube having first and second lumens. A molded handle is coupled to the proximal end of the tube with an opening aligned with the first lumen. Further, a wall adjacent the opening of the handle defines a slot and is located diametrically opposite the second lumen. A tubular reinforcement member is located within the second lumen and the handle is provided with a second opening, thereby having a communication with the second lumen. In another embodiment a lead/catheter introducer includes an implantable lead or catheter having an elongated first lumen through which the lead or catheter passes and a second lumen extends parallel to the first lumen along at least a distal portion thereof. A tubular reinforcement member is disposed within the second lumen. The tubular reinforcement member further includes an internal lumen and a curvable stylet disposed in the lumen.

    摘要翻译： 导引器构造有具有第一和第二腔的细长管。 模制手柄与管的近端连接，开口与第一内腔对准。 此外，与手柄的开口相邻的壁限定了狭槽，并且位于与第二内腔完全相对的位置。 管状加强构件位于第二内腔内，手柄设置有第二开口，从而与第二腔相连通。 在另一个实施例中，引导/导管导引器包括具有细长的第一内腔的可植入引线或导管，所述引导件或导管通过所述细长的第一内腔，并且沿其至少其远端部分平行于所述第一内腔延伸的第二腔。 管状加强构件设置在第二内腔内。 管状加强构件还包括内腔和设置在内腔中的可调节探针。

    Method of fabricating a medical electrical lead
    23.
    发明授权
    Method of fabricating a medical electrical lead 失效
    制造医用电线的方法

    公开(公告)号：US5957970A

    公开(公告)日：1999-09-28

    申请号：US25485

    申请日：1998-02-18

    申请人： Bret R. Shoberg ,  Matthew D. Bonner ,  Timothy G. Laske

    发明人： Bret R. Shoberg ,  Matthew D. Bonner ,  Timothy G. Laske

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/0563

    摘要： A method of producing a lead which is isodiametric or nearly so over the region in which an elongated coiled electrode is located and which can optionally be manufactured starting from a single extruded tubular lead body of constant diameter and the lead so produced. Rather than molding the electrode into the surface of the lead or machining the electrode so that it is flush with the surface of the lead, the present invention instead employs an extruded, multiple lumen lead body of circular cross-section which has material cut away or otherwise removed in one or more regions spaced from one another around the lead body and extending longitudinally along the region of the lead body where the coil electrode is to be located or a lead body which is so molded. The areas in which material is removed or is absent are preferably located in regions where the lead body wall is thickest, for example between adjacent lumens. The removal of material may result in one or more elongated, generally planar surfaces spaced from one another around the circumference of the lead body or may result in elongated indentations spaced from one another around the circumference of the lead body. The removal or absence of material renders the lead body more compressible in the region the electrode is to be located.

    摘要翻译： 一种制造在其中设置有细长卷绕电极的区域上是等距或接近的引线的方法，其可以任选地从具有恒定直径的单个挤出管状引线体和由此产生的引线开始制造。 不是将电极模制到引线的表面或加工电极以使其与引线的表面齐平，而是本发明使用具有圆形横截面的挤出的多腔引线体，其具有切除的材料或 否则在围绕引线主体彼此间隔开的一个或多个区域中移除，并沿着线体电极要被定位的引线体的区域或者如此模制的引线体纵向延伸。 材料被去除或不存在的区域优选地位于引线体壁最厚的区域中，例如在相邻流明之间。 去除材料可能导致一个或多个细长的，大致平坦的表面围绕引线主体的圆周彼此间隔开，或者可能导致围绕引线主体的圆周彼此间隔开的细长的凹陷。 材料的去除或不存在使得引线体在电极将被定位的区域中更加可压缩。

    Implant system including guiding accessory and methods of use
    25.
    发明授权
    Implant system including guiding accessory and methods of use 有权
    植入系统包括引导配件和使用方法

    公开(公告)号：US08758365B2

    公开(公告)日：2014-06-24

    申请号：US13197156

    申请日：2011-08-03

    申请人： Matthew D. Bonner ,  Vladimir P. Nikolski

    发明人： Matthew D. Bonner ,  Vladimir P. Nikolski

    IPC分类号： A61B19/00

    CPC分类号： A61N1/056 ,  A61N1/37205 ,  A61N1/3756

    摘要： A guiding accessory, for use in conjunction with a guidewire and a catheter of an implant system, facilitates passage of an elongate and flexible conductor of a relatively compact therapy delivery device to an implant site, for example, within the cardiac venous system, when a therapy generator of the device is held within a distal portion of the catheter, and the catheter, device and guiding accessory are advanced along the guidewire. The guiding accessory includes a helically extending wall that forms a lumen within which the device conductor and guidewire extend. After advancing the catheter, guiding accessory and device to the implant site, the helically extending wall is unwound from around the device conductor, for removal, preferably, by pulling proximally on a tension line, which is attached to a proximal end of the wall.

    摘要翻译： 用于与导线和植入物系统的导管一起使用的引导附件有助于使相对紧凑的治疗递送装置的细长柔性导体通过例如心脏静脉系统内的植入部位， 该装置的治疗发生器被保持在导管的远端部分内，并且导管，装置和导向附件沿着导丝线前进。 引导配件包括螺旋形延伸的壁，其形成设备导体和导丝延伸的管腔。 在推进导管之后，引导附件和装置到植入部位，螺旋形延伸的壁从装置导体周围展开，以便优选地通过在附着在壁的近端的张力线上向近侧拉动来移除。

    Cardiac mapping instrument with shapeable electrode
    26.
    发明授权
    Cardiac mapping instrument with shapeable electrode 有权
    具有可塑电极的心脏测绘仪

    公开(公告)号：US08623010B2

    公开(公告)日：2014-01-07

    申请号：US12480926

    申请日：2009-06-09

    申请人： Jon M. Ocel ,  Roderick E. Briscoe ,  David E. Francischelli ,  Scott E. Jahns ,  James R. Keogh ,  Katherine S. Jolly ,  Matthew D. Bonner

    发明人： Jon M. Ocel ,  Roderick E. Briscoe ,  David E. Francischelli ,  Scott E. Jahns ,  James R. Keogh ,  Katherine S. Jolly ,  Matthew D. Bonner

    IPC分类号： A61B18/14

    CPC分类号： A61B5/042 ,  A61B5/7475 ,  A61B18/14 ,  A61B2017/2927 ,  A61B2018/1472 ,  A61N1/056

    摘要： An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.

    摘要翻译： 公开了一种包括细长轴和非导电手柄的仪器。 轴限定近端部分和远端部分。 远侧部分形成导电尖端。 此外，轴适于从直状态转变到第一弯曲状态。 轴能够独立地保持与直线状态和第一弯曲状态相关联的不同形状。 手柄刚性地联接到轴的近端部分。 该仪器可用于心脏起搏和/或心脏在心脏跳动中临时起搏的作用，以优化用于治疗患有充血性心力衰竭和心室异常不适和/或用于外科手术切除手术的患者的心室导线的放置 。

    IMPLANT SYSTEM INCLUDING GUIDING ACCESSORY AND METHODS OF USE
    27.
    发明申请
    IMPLANT SYSTEM INCLUDING GUIDING ACCESSORY AND METHODS OF USE 有权
    包括引导附件和使用方法的植入系统

    公开(公告)号：US20130035748A1

    公开(公告)日：2013-02-07

    申请号：US13197156

    申请日：2011-08-03

    申请人： Matthew D. Bonner ,  Vladimir P. Nikolski

    发明人： Matthew D. Bonner ,  Vladimir P. Nikolski

    IPC分类号： A61F2/84

    CPC分类号： A61N1/056 ,  A61N1/37205 ,  A61N1/3756

    摘要： A guiding accessory, for use in conjunction with a guidewire and a catheter of an implant system, facilitates passage of an elongate and flexible conductor of a relatively compact therapy delivery device to an implant site, for example, within the cardiac venous system, when a therapy generator of the device is held within a distal portion of the catheter, and the catheter, device and guiding accessory are advanced along the guidewire. The guiding accessory includes a helically extending wall that forms a lumen within which the device conductor and guidewire extend. After advancing the catheter, guiding accessory and device to the implant site, the helically extending wall is unwound from around the device conductor, for removal, preferably, by pulling proximally on a tension line, which is attached to a proximal end of the wall.

    摘要翻译： 用于与导线和植入物系统的导管一起使用的引导附件有助于使相对紧凑的治疗递送装置的细长柔性导体通过例如心脏静脉系统内的植入部位， 该装置的治疗发生器被保持在导管的远端部分内，并且导管，装置和导向附件沿着导丝线前进。 引导配件包括螺旋形延伸的壁，其形成设备导体和导丝延伸的管腔。 在推进导管之后，引导附件和装置到植入部位，螺旋形延伸的壁从装置导体周围展开，以便优选地通过在附着在壁的近端的张力线上向近侧拉动来移除。

    IMPLANTABLE MEDICAL DEVICE FIXATION
    28.
    发明申请
    IMPLANTABLE MEDICAL DEVICE FIXATION 审中-公开
    可植入医疗器械固定

    公开(公告)号：US20120172690A1

    公开(公告)日：2012-07-05

    申请号：US13284761

    申请日：2011-10-28

    申请人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

    发明人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

    IPC分类号： A61B5/145 ,  A61B19/00 ,  A61N1/36 ,  A61N1/365 ,  A61B5/04 ,  A61N1/05

    CPC分类号： A61N1/0573 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756

    摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

    摘要翻译： 组件包括可植入医疗装置（IMD），其包括导电外壳和连接到IMD的固定元件组件。 固定元件组件包括一组主动固定齿和绝缘体，用于将一组主动固定齿与可植入医疗装置的导电外壳电隔离。 组合中的主动固定齿可从弹簧加载位置展开，其中主动固定尖端的远端尖端远离可植入医疗装置指向钩状位置，在该位置，主动固定齿可向着可植入医疗装置弯回。 主动固定齿构造成在展开时将可植入医疗装置固定到患者组织，同时活动固定齿的远端定位成与患者组织相邻。

    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE
    30.
    发明申请
    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE 有权
    用于生物组织的内部注射用于组织的装置和方法

    公开(公告)号：US20100063475A1

    公开(公告)日：2010-03-11

    申请号：US12621037

    申请日：2009-11-18

    申请人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    发明人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    IPC分类号： A61M31/00 ,  A61M5/32

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。