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55 条记录 (耗时 0.035 秒)

    Alkyl derivatives of 4,5-dehydro PGF.sub.1
    27.
    发明授权
    Alkyl derivatives of 4,5-dehydro PGF.sub.1 失效
    4,5-脱氢PGF的烷基衍生物（HD 1

    公开(公告)号：US4048328A

    公开(公告)日：1977-09-13

    申请号：US696453

    申请日：1976-06-15

    申请人： Nedumparambil A. Abraham ,  Jehan F. Bagli ,  Tibor Bogri

    发明人： Nedumparambil A. Abraham ,  Jehan F. Bagli ,  Tibor Bogri

    IPC分类号： C07C405/00 ,  C07F9/40 ,  C07F9/54 ,  A61K31/19 ,  A61K31/215 ,  C07C177/00

    CPC分类号： C07F9/4006 ,  C07C405/00 ,  C07F9/5407

    摘要： 15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, anti-hypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

    摘要翻译： 9,15-双加氧前列腺-13-烯酸，前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物，其低级烷基酯及其同系物，以及 公开了制备这些衍生物的方法。 该化合物具有降血压，抗高血压，支气管痉挛，胃酸分泌抑制，流产，发情同步和排卵调节特性。 该化合物还抑制血小板的聚集并促进聚集的血小板的解聚。 还公开了它们的使用方法。

    Intermediates for prostanoic acids
    28.
    发明授权
    Intermediates for prostanoic acids 失效
    前列腺酸中间体

    公开(公告)号：US4007171A

    公开(公告)日：1977-02-08

    申请号：US567036

    申请日：1975-04-10

    申请人： Nedumparambil A. Abraham ,  Jehan F. Bagli ,  Tibor Bogri

    发明人： Nedumparambil A. Abraham ,  Jehan F. Bagli ,  Tibor Bogri

    IPC分类号： C07C405/00 ,  C07F9/40 ,  C07F9/54 ,  C07C69/74

    CPC分类号： C07F9/5407 ,  C07C405/00 ,  C07F9/4006

    摘要： 15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

    摘要翻译： 9,15-双加氧前列腺-13-烯酸，前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物，其低级烷基酯及其同系物，以及 公开了制备这些衍生物的方法。 该化合物具有低血压，抗高血压，支气管痉挛，胃酸分泌抑制，流产，发情同步和排卵调节特性。 该化合物还抑制血小板的聚集并促进聚集的血小板的解聚。 还公开了它们的使用方法。