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公开(公告)号：US5954752A
公开(公告)日：1999-09-21
申请号：US846938
申请日：1997-04-30
申请人： Luc R. Mongeon , Michael R. S. Hill
发明人： Luc R. Mongeon , Michael R. S. Hill
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3987
摘要： In an implantable pacemaker.backslash.cardioverter.backslash.defibrillator, a system for correlating the delivery of an atrial cardioversion therapy to an optimum blood pressure to effect delivery of the therapy when the volume of the atrium is minimized. In a first embodiment, the blood pressure in the atrium or ventricle is monitored and delivery is timed to a low blood pressure occurring as blood is emptying from the atrium. In a variation ventricular pacing may be provided to ensure that the ventricles are contracting forcefully and at a rate which optimizes atrial emptying. In a second embodiment, the delivery of the cardioversion therapy is also timed to an optimum point or phase of the respiratory cycle. The optimum point or phase of the respiration cycle depends in part on the chamber to be cardioverted and the location of the cardioversion electrodes with respect to the chamber.
摘要翻译： 在植入式心脏起搏器+ 544心律转复+ 544除颤器中，一种用于将心房复律治疗的输送与最佳血压相关联的系统，以在心房体积最小化时实现治疗递送。 在第一实施例中，监测心房或心室中的血压，并且当血液从心房排空时，输送定时到低血压。 在一个变化中可以提供心室起搏，以确保心室有力地收缩，并以优化心房排空的速度。 在第二实施例中，复律疗法的传递也定时到呼吸周期的最佳点或阶段。 呼吸循环的最佳点或相位部分地取决于要被转复的腔室和心脏复律电极相对于腔室的位置。
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公开(公告)号：US08417334B2
公开(公告)日：2013-04-09
申请号：US10039307
申请日：2001-10-26
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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23.发明授权Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置公开(公告)号：US07672733B2
公开(公告)日：2010-03-02
申请号：US11116970
申请日：2005-04-28
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。
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24.发明授权公开(公告)号：US07218964B2
公开(公告)日：2007-05-15
申请号：US10035319
申请日：2001-10-26
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering closed loop electrical stimulation to one or more predetermined portions of a portion of excitable tissue of the spinal cord of a patient; and monitoring one or more physiologic indices of the body. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the spinal cord of a patient's body based upon one or more aspects of the physiologic indices.
摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将闭环电刺激递送到患者脊髓的可激发组织的一部分的一个或多个预定部分; 并监测身体的一个或多个生理指标。 也就是说，使用闭环反馈控制器基于生理指标的一个或多个方面对患者身体的脊髓的预选区域施加电刺激。
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公开(公告)号：US07010345B2
公开(公告)日：2006-03-07
申请号：US09999723
申请日：2001-10-26
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.
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公开(公告)号：US06845268B2
公开(公告)日：2005-01-18
申请号：US10090053
申请日：2002-02-28
CPC分类号： A61N1/3622
摘要： A device implemented software system for use with atrial and/or ventricular rate stabilization to adjust DDD/R rate stabilization while maintaining intrinsic ventricular response timing to overdrive the intrinsic sinus (atrial) rate. Specifically, the algorithm is directed toward maintaining ventricular activation/contraction sequence while improving atrial and ventricular hemodynamics. Generally, the PAV interval is prolonged subsequent to a sensed premature beat. In an ultimate embodiment, the algorithm enables extension of the PAV interval subsequent to a non-conducted premature atrial event. The extension of the PAV interval allows for the simultaneous smoothing of the atrial and ventricular rates.
摘要翻译： 一种设备实现的软件系统用于心房和/或心室速率稳定以调节DDD / R速率稳定，同时保持内在的心室响应时间以超速内在窦（心房）率。 具体地，该算法旨在维持心室激活/收缩序列，同时改善心房和心室血流动力学。 通常，在感测到的过早搏动之后PAV间隔延长。 在最终实施例中，该算法能够在非传导性早搏心房事件之后扩展PAV间期。 PAV间期的延长允许同时平滑心房和心室率。
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公开(公告)号：US06542774B2
公开(公告)日：2003-04-01
申请号：US09897630
申请日：2001-07-02
IPC分类号： A61N136
CPC分类号： A61N1/36114 , A61B17/3417 , A61B2017/00243 , A61B2017/00969 , A61B2017/0243 , A61B2017/3445 , A61B2017/3449 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3962
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
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28.发明授权Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 有权在医疗过程之前和期间，用于气管内/食管刺激的方法和系统公开(公告)号：US06532388B1
公开(公告)日：2003-03-11
申请号：US09670369
申请日：2000-09-26
申请人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh , David E. Euler , Michael R. Ujhelyi , Nancy J. Rakow
发明人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh , David E. Euler , Michael R. Ujhelyi , Nancy J. Rakow
IPC分类号： A61N118
CPC分类号： A61N1/362 , A61M5/14276 , A61N1/0517 , A61N1/0519 , A61N1/0556 , A61N1/056 , A61N1/36007 , A61N1/3601 , A61N1/36014 , A61N1/36017 , A61N1/36114 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.
摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状况。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激以将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续进行医学过程。 还提供用于执行医疗程序的系统和设备。
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29.依法登记的发明Mechanism for adjusting the exposed surface area and position of an electrode along a lead body 失效用于调节电极沿着引线体的暴露表面积和位置的机构
公开(公告)号：USH1905H
公开(公告)日：2000-10-03
申请号：US821899
申请日：1997-03-21
申请人： Michael R. S. Hill
发明人： Michael R. S. Hill
CPC分类号： A61N1/0563 , A61N1/056
摘要： An endocardial pacing and/or cardioversion/defibrillation lead having a plurality of electrodes and a mechanism for adjusting the exposed surface area of one or more electrode and/or the position and/or angular orientation of an electrode along a lead body. A fixed exposed, flexible, elongated commutator surface is provided extending along the lead body intermediate the proximal and distal lead body ends coupled by an electrical lead conductor extending to the proximal end of the lead body. A movable electrode assembly is provided that fits over and slides along the lead body, including the fixed commutator surface, that supports an exposed movable electrode on it. The movable electrode assembly includes at least one flexible, elongated, movable commutator surface within it that is electrically connected with the movable electrode. Electrical contact is established between the movable electrode and the lead connector end through contact of the fixed and movable commutator surfaces in a contact segment of contact area that varies with the relative movement of the movable contact surface with respect to the fixed contact surface. The position and exposed surface area of the movable electrode may be adjusted even further by use of a further electrode adjustable area outer insulating sheath positioned over the movable electrode assembly.
摘要翻译： 具有多个电极的心内起搏和/或心脏复律/除颤引线，以及用于调节沿着引线体的电极的一个或多个电极的暴露表面积和/或电极的位置和/或角度取向的机构。 提供固定的暴露的，柔性的，细长的换向器表面，其沿着引线体延伸，其中间距离引线主体端部通过延伸到引线主体的近端的电引线导体连接。 提供可移动电极组件，其沿着引线主体装配并滑动，包括固定换向器表面，其在其上支撑暴露的可动电极。 可移动电极组件包括与可动电极电连接的至少一个柔性的，细长的，可动的换向器表面。 在可动电极和引线连接器端之间通过接触区域中的固定和可动的换向器表面与可动接触表面相对于固定接触表面的相对运动而变化的接触段接触而形成电接触。 可以通过使用位于可动电极组件上方的另外的电极可调节区域外部绝缘护套来进一步调节可动电极的位置和暴露的表面积。
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公开(公告)号：US5846263A
公开(公告)日：1998-12-08
申请号：US764568
申请日：1996-12-13
CPC分类号： A61N1/3962 , A61N1/3622
摘要： An implantable pacemaker employing an arrhythmia prevention pacing modality particularly optimized for inclusion in dual chamber pacemakers and anti-arrhythmia devices which include dual chamber pacemakers. When the pacing mode is in effect, the device alters timing of scheduled atrial and/or ventricular pacing pulses in response to depolarizations sensed during the refractory periods and to ventricular depolarizations sensed outside of the pacemaker's A-V escape intervals. The arrhythmia prevention pacing mode is activated and deactivated in conjunction with the operation of arrhythmia detection features which may also be employed by the device to trigger delivery of anti-arrhythmia therapies.
摘要翻译： 采用心律不齐预防起搏模式的植入式起搏器，其特别优化包括在双室起搏器和包括双室起搏器的抗心律失常装置中。 当起搏模式有效时，设备响应于在不应期期间感测到的去极化以及在起搏器的A-V逃逸间隔之外感测到的心室去极化来改变调度的心房和/或心室起搏脉冲的时间。 心律失常预防起搏模式与心律失常检测特征的操作一起被激活和失活，该功能也可以由该装置用于触发抗心律失常治疗的递送。
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