公开(公告)号：US20180105886A1

公开(公告)日：2018-04-19

申请号：US15724890

申请日：2017-10-04

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US09632093B2

公开(公告)日：2017-04-25

申请号：US15197105

申请日：2016-06-29

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold S. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: G01N33/574 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US09399800B2

公开(公告)日：2016-07-26

申请号：US14827013

申请日：2015-08-14

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C07H21/02 ,  C12Q1/68 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20150354013A1

公开(公告)日：2015-12-10

申请号：US14827013

申请日：2015-08-14

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/68 ,  C12Q1/40 ,  C12Q1/37

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

Abstract translation: 本文件涉及检测恶变前期和恶性肿瘤的方法和材料。 例如，提供了用于确定来自哺乳动物的粪便样品是否含有肿瘤的核酸标记物或多肽标记物的方法和材料。

公开(公告)号：US09121070B2

公开(公告)日：2015-09-01

申请号：US14168552

申请日：2014-01-30

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: A61K38/00 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

Abstract translation: 本文件涉及检测恶变前期和恶性肿瘤的方法和材料。 例如，提供了用于确定来自哺乳动物的粪便样品是否含有肿瘤的核酸标记物或多肽标记物的方法和材料。

公开(公告)号：US20140205517A1

公开(公告)日：2014-07-24

申请号：US14229435

申请日：2014-03-28

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  Jonathan J. Harrington ,  Hongzhi Zou ,  Patrick S. Quint ,  William R. Taylor

IPC: B01L3/00

CPC classification number: B01L3/00 ,  A61B10/0038 ,  A61B10/0096 ,  B01L3/5029 ,  C12Q1/6806 ,  C12Q2565/507 ,  C12Q2563/143 ,  C12Q2527/125

Abstract: This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided.

Abstract translation: 本文件提供了收集和处理复杂大分子混合物（例如粪便样品）中涉及的方法和材料。 例如，粪便收集装置，用于稳定存在于粪便中的核酸和多肽的缓冲液以及使用序列特异性捕获探针（例如，设计为与特定靶核酸杂交的核酸序列）直接从复合物捕获靶核酸的试剂盒 提供大分子混合物（例如，粪便样品），而不需要执行先前的富集，分离或纯化核酸组分的步骤。