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21.发明授权
公开(公告)号：US6146663A
公开(公告)日：2000-11-14
申请号：US929226
申请日：1997-09-09
CPC分类号： A61K9/5153 , A61K9/5192 , Y10S977/773 , Y10S977/788 , Y10S977/795 , Y10S977/906
摘要： This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified in an aqueous solution or suspension comprising a phospholipid and a bile salt.
摘要翻译： 本发明涉及可在无菌条件下过滤的稳定的纳米颗粒，其包含至少一种疏水性，水不溶性和非水分散性聚合物或共聚物（和任选的活性成分），其在水溶液或悬浮液中乳化，包括 磷脂和胆汁盐。
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22.发明申请公开(公告)号：US20060178305A1
公开(公告)日：2006-08-10
申请号：US11293761
申请日：2005-12-02
申请人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse Cedarbaum
发明人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse Cedarbaum
IPC分类号： A61K38/17 , A61K31/7072 , A61K31/513 , A61K31/525
CPC分类号： A61K31/513 , A61K31/505 , A61K31/519 , A61K31/7068 , A61K38/179 , A61K38/18 , A61K45/00 , A61K2300/00
摘要： This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
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公开(公告)号：US20050226940A1
公开(公告)日：2005-10-13
申请号：US11149178
申请日：2005-06-10
IPC分类号： A61K31/335 , A61K31/337 , A61K31/4745 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/43 , A61K45/06 , A61P35/00 , C07D305/14
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/337 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/20 , A61K38/21 , A61K38/50 , A61K45/06 , C07D305/14 , C12Y305/01001 , Y10S514/836 , Y10S514/922 , A61K31/28 , A61K2300/00
摘要： Antitumour combinations consisting of taxol or Taxotère or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
摘要翻译： 由紫杉醇或泰索帝或其类似物组合的抗肿瘤组合与用于治疗肿瘤性疾病的至少一种治疗有用的物质组合。
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公开(公告)号：US06933320B2
公开(公告)日：2005-08-23
申请号：US10097926
申请日：2002-03-15
IPC分类号： A61K45/00 , A61K31/09 , A61K31/135 , A61K31/167 , A61K31/337 , A61K31/47 , A61K31/475 , A61K31/704 , A61K45/06 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K45/06 , A61K31/09 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/337 , A61K31/47 , A61K31/4745 , A61K31/70 , A61K31/7072 , Y10S514/922 , A61K33/24 , A61K31/704 , A61K31/475 , A61K31/335 , A61K2300/00
摘要： An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients is provided. Methods of using these pharmaceutical preparations for the treatment of solid carcinomas and the like are also provided.
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公开(公告)号：US20050075295A1
公开(公告)日：2005-04-07
申请号：US10995998
申请日：2004-11-23
IPC分类号： A61K45/00 , A61K31/09 , A61K31/135 , A61K31/167 , A61K31/337 , A61K31/47 , A61K31/475 , A61K31/704 , A61K45/06 , A61P35/00 , A61P35/04 , A61P43/00 , A61K31/7048 , A61K31/4745 , A61K31/16
CPC分类号： A61K45/06 , A61K31/09 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/337 , A61K31/47 , A61K31/4745 , A61K31/70 , A61K31/7072 , Y10S514/922 , A61K33/24 , A61K31/704 , A61K31/475 , A61K31/335 , A61K2300/00
摘要： An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients is provided. Methods of using these pharmaceutical preparations for the treatment of solid carcinomas and the like are also provided.
摘要翻译： 提供了包含选自紫杉烷，烷化剂，抗代谢物，长春花生物碱，铂化合物，表鬼臼毒素和抗生素作为活性成分的二苯乙烯衍生物和抗癌化合物的抗肿瘤组合。 还提供了使用这些药物制剂治疗固体癌等的方法。
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公开(公告)号：US06214863B1
公开(公告)日：2001-04-10
申请号：US09371520
申请日：1999-08-10
IPC分类号： A61K31335
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/337 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/20 , A61K38/21 , A61K38/50 , A61K45/06 , C07D305/14 , C12Y305/01001 , Y10S514/836 , Y10S514/922 , A61K31/28 , A61K2300/00
摘要： Disclosed are combinations of a taxoid, an alkylating agent and an anthracycline antibiotic, which compositions exhibit therapeutic synergy in the treatment of cancer.
摘要翻译： 披露了紫杉烷，烷化剂和蒽环类抗生素的组合，该组合物在治疗癌症中表现出治疗协同作用。
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公开(公告)号：US5908835A
公开(公告)日：1999-06-01
申请号：US967036
申请日：1997-11-10
IPC分类号： A61K31/335 , A61K31/337 , A61K31/4745 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/43 , A61K45/06 , A61P35/00 , C07D305/14 , A01N43/04 , A61K31/70
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/337 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/20 , A61K38/21 , A61K38/50 , A61K45/06 , C07D305/14 , C12Y305/01001 , Y10S514/836 , Y10S514/922
摘要： Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than the expected additive effect of its individual components.
摘要翻译： 公开了包含紫杉醇，泰索帝或其衍生物与蒽环类抗生素组合的抗肿瘤组合物，该组合具有大于其各个组分的预期加成效应的药理活性。
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公开(公告)号：US5728687A
公开(公告)日：1998-03-17
申请号：US424470
申请日：1995-05-09
IPC分类号： A61K31/335 , A61K31/337 , A61K31/4745 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/43 , A61K45/06 , A61P35/00 , C07D305/14
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/337 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/20 , A61K38/21 , A61K38/50 , A61K45/06 , C07D305/14 , C12Y305/01001 , Y10S514/836 , Y10S514/922
摘要： Pharmaceutical compositions having therapeutic synergy comprising taxol or Taxotere or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
摘要翻译： PCT No.PCT / FR93 / 01096 Sec。 371日期1995年5月9日第 102（e）日期1995年5月9日PCT提交1993年11月8日PCT公布。 公开号WO94 / 10995 日期：1994年5月26日具有包含紫杉醇或泰索帝或其类似物的治疗协同作用的药物组合物与用于治疗肿瘤疾病的至少一种治疗有用的物质组合。
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