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公开(公告)号：US20070048834A1
公开(公告)日：2007-03-01
申请号：US11552710
申请日：2006-10-25
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： C12P21/06 , C07H21/04 , C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20070048260A1
公开(公告)日：2007-03-01
申请号：US11551362
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070041974A1
公开(公告)日：2007-02-22
申请号：US11549868
申请日：2006-10-16
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K39/395 , C07K16/24 , C12P21/04
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070264689A1
公开(公告)日：2007-11-15
申请号：US11767350
申请日：2007-06-22
申请人： Jane Gross , Wenfeng Xu , Randal Henne , Francis Grant
发明人： Jane Gross , Wenfeng Xu , Randal Henne , Francis Grant
CPC分类号： C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.”
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公开(公告)号：US20070166794A1
公开(公告)日：2007-07-19
申请号：US11551811
申请日：2006-10-23
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20070140964A1
公开(公告)日：2007-06-21
申请号：US11553241
申请日：2006-10-26
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： A61K51/00 , A61K39/395 , A61K38/17
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20070098682A1
公开(公告)日：2007-05-03
申请号：US11551136
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070092485A1
公开(公告)日：2007-04-26
申请号：US11551807
申请日：2006-10-23
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： A61K38/17
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070059825A1
公开(公告)日：2007-03-15
申请号：US11551127
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C12N5/08
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070049530A1
公开(公告)日：2007-03-01
申请号：US11552653
申请日：2006-10-25
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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