公开(公告)号：US20050148010A1

公开(公告)日：2005-07-07

申请号：US11058663

申请日：2005-02-15

申请人： Brian Ward ,  David Ornitz ,  Michael Deines ,  Thomas Bittick

发明人： Brian Ward ,  David Ornitz ,  Michael Deines ,  Thomas Bittick

IPC分类号： C07H21/04 ,  C12N9/00 ,  C12P19/34 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6813 ,  C12Q2565/137 ,  C12Q2527/125

摘要： A composition suitable for formulation of an enzymatic reaction mixture, the composition comprising a reaction component essential for an ex-vivo non-polymerase enzymatic reaction in which a substrate is catalyzed by an enzyme in a reaction mixture to form a product, and a tracer compatible with the enzyme, the composition being substantially free of the substrate.

摘要翻译： 一种适于制备酶反应混合物的组合物，该组合物包含对于在反应混合物中催化底物以形成产物的离体非聚合酶酶反应所必需的反应组分，以及示踪剂相容性 与该酶组合物基本上不含底物。

公开(公告)号：US06902926B1

公开(公告)日：2005-06-07

申请号：US10039770

申请日：2001-11-09

申请人： Gary E. Ward ,  Carolyn G. Conant ,  Brian Ward

发明人： Gary E. Ward ,  Carolyn G. Conant ,  Brian Ward

IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  C07K14/45 ,  C07K16/20 ,  C12N1/10 ,  C12Q1/68

CPC分类号： A61K39/012 ,  A61K39/00 ,  A61K39/002 ,  C07K14/45 ,  C07K16/20 ,  C07K2319/00

摘要： The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provided. In addition the invention provides methods involving use of the polypeptides, nucleic acids, and binding polypeptides, such as antibodies, for the prevention and treatment of Toxoplasmosis.

公开(公告)号：US5056293A

公开(公告)日：1991-10-15

申请号：US539437

申请日：1990-06-18

申请人： David C. Richards ,  Maurice S. Williams ,  Brian Ward

发明人： David C. Richards ,  Maurice S. Williams ,  Brian Ward

IPC分类号： A22C13/02 ,  B65B9/18

CPC分类号： B65B9/18 ,  A22C13/02 ,  A22C2013/026

摘要： An annular container mounted at the base of a passage between a layering tube and a central mandrel is charged with a layered tube of flexible tubing delivered over a floating mandrel when coaxially in contact with mandrel by driving rollers coacting with pinch rollers on the floating mandrel. The tubing passes over the mandrel and gathers in the layering tube while being compacted by two sets of shoes reciprocated 180.degree. out of phase by rotating discs and connecting rods. When sufficient tubing has been delivered the floating mandrel is raised to enable a hot wire to pass between the mandrels to sever the tubing. The layering tube and central mandrel with the container can then be carried by a turntable through further stationary positions where the layered tubing is further compressed by reciprocable rings, a lid is put on the container to form a cassette and the cassette is discharged.

公开(公告)号：US4934529A

公开(公告)日：1990-06-19

申请号：US384798

申请日：1989-07-25

申请人： David C. Richards ,  Maurice S. Williams ,  Brian Ward

发明人： David C. Richards ,  Maurice S. Williams ,  Brian Ward

IPC分类号： B65H75/16 ,  B65B9/15 ,  B65B67/12 ,  B65F1/06 ,  B65H67/04

CPC分类号： B65F1/062 ,  B65B67/1277 ,  B65B9/15 ,  Y10S206/802

摘要： In a cassette for dispensing flexible tubing, the tubing is packed in a tightly layered mass between a tubular core and the vertical wall of a casing. Subsequently a cap is mounted in an expanded portion of the casing. The cap has a vertical part fitting the portion and a flange partially overlapping the pack. The cap is secured against rising by punching tongues out of the portion that engage in a groove in the part. The inner surface of part aligns with surface of casing. The junction beneath expanded portion prevents cap from descending as the tubing is dispensed from the top of the pack, over the core edge and through core.

公开(公告)号：US08536303B2

公开(公告)日：2013-09-17

申请号：US11972459

申请日：2008-01-10

申请人： Alyssa Panitch ,  Brandon Seal ,  Brian Ward

发明人： Alyssa Panitch ,  Brandon Seal ,  Brian Ward

IPC分类号： A61K38/00 ,  A61K51/00 ,  C07K5/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： A61K38/16 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.

摘要翻译： 本发明提供HSP27激酶的多肽抑制剂，其组合物，以及使用这些多肽和组合物用于各种治疗用途的方法。

公开(公告)号：US20110136118A1

公开(公告)日：2011-06-09

申请号：US12996403

申请日：2009-06-16

申请人： Carol Kreader ,  Brian Ward

发明人： Carol Kreader ,  Brian Ward

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6823 ,  C12Q1/6851 ,  C12Q2561/113 ,  C12Q2561/109 ,  C12Q2537/149 ,  C12Q2521/301 ,  C12Q2565/1015 ,  C12Q2525/161 ,  C12Q2525/131

摘要： Provided are methods and kits for detecting amplification of a target nucleic acid during a real time quantitative polymerase chain reaction process using a universal detection system. The detection system uses an unlabeled probe that detects the amplified target nucleic acid and interacts with a universal detection module.

摘要翻译： 提供了用于在使用通用检测系统的实时定量聚合酶链反应过程中检测靶核酸的扩增的方法和试剂盒。 检测系统使用检测扩增的靶核酸并与通用检测模块相互作用的未标记的探针。

公开(公告)号：US20100018707A1

公开(公告)日：2010-01-28

申请号：US12180219

申请日：2008-07-25

申请人： Richard S. Wheeler ,  Chandler C. Newhall ,  Roger R. Myers ,  Brian Ward ,  Brian B. Beall ,  Harold D. Brannon

发明人： Richard S. Wheeler ,  Chandler C. Newhall ,  Roger R. Myers ,  Brian Ward ,  Brian B. Beall ,  Harold D. Brannon

IPC分类号： E21B43/267

CPC分类号： E21B43/267 ,  C09K8/703 ,  C09K8/80 ,  C09K2208/30

摘要： In a method of hydraulically fracturing a hydrocarbon-bearing subterranean formation, a proppant stage is introduced into the fracture which contains a gaseous fluid and an ultra lightweight proppant suspended in a viscosified aqueous fluid. The gaseous fluid of the proppant stage contains at least about 90 volume percent of the combination of gaseous fluid and aqueous fluid. A pad fluid may first be introduced into the formation, the pad fluid containing a gaseous fluid and, optionally, an aqueous fluid. The gaseous fluid of the pad fluid mixture typically contains at least 70 volume percent of the mixture.

摘要翻译： 在含烃地层的水力压裂方法中，将支撑剂阶段引入含有气态流体的裂缝和悬浮在粘稠水溶液中的超轻质支撑剂。 支撑剂阶段的气态流体含有至少约90体积％的气态流体和含水流体的组合。 衬垫流体可以首先被引入到地层中，衬垫流体含有气体流体和任选的含水流体。 衬垫流体混合物的气体流体通常含有至少70体积％的混合物。

公开(公告)号：US20090215086A1

公开(公告)日：2009-08-27

申请号：US12097037

申请日：2006-12-12

申请人： Momar Ndao ,  Brian Ward ,  Peter Krause ,  Mark W. Duncan ,  Mike Edwards ,  Terence William Spithill

发明人： Momar Ndao ,  Brian Ward ,  Peter Krause ,  Mark W. Duncan ,  Mike Edwards ,  Terence William Spithill

IPC分类号： G01N33/569

CPC分类号： G01N33/56905 ,  Y02A50/58

摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.

摘要翻译： 本发明提供了可用于限定患者中的婴儿状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受感染的婴儿或未感染巴贝的受试者样品分类。 生物标志物可以通过SELDI质谱检测。

公开(公告)号：US20050210535A1

公开(公告)日：2005-09-22

申请号：US11089047

申请日：2005-03-24

申请人： Gary Ward ,  Carolyn Conant ,  Brian Ward

发明人： Gary Ward ,  Carolyn Conant ,  Brian Ward

IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  C07K14/45 ,  C07K16/20 ,  A01K67/00 ,  A61K38/17 ,  C07K14/37 ,  C12Q1/68

CPC分类号： A61K39/012 ,  A61K39/00 ,  A61K39/002 ,  C07K14/45 ,  C07K16/20 ,  C07K2319/00

摘要： The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provided. In addition the invention provides methods involving use of the polypeptides, nucleic acids, and binding polypeptides, such as antibodies, for the prevention and treatment of Toxoplasmosis.

摘要翻译： 本发明提供衍生自TgAMA-1的多肽片段，编码多肽片段的核酸和TgAMA结合多肽如抗体。 还提供了使用多肽和核酸分子来生产疫苗的方法。 此外，本发明提供涉及使用多肽，核酸和结合多肽（例如抗体）来预防和治疗弓形体病的方法。

公开(公告)号：US20050148011A1

公开(公告)日：2005-07-07

申请号：US11058675

申请日：2005-02-15

申请人： Brian Ward ,  David Ornitz ,  Michael Deines ,  Thomas Bittick

发明人： Brian Ward ,  David Ornitz ,  Michael Deines ,  Thomas Bittick

IPC分类号： C07H21/04 ,  C12N9/00 ,  C12P19/34 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6813 ,  C12Q2565/137 ,  C12Q2527/125

摘要： A composition suitable for formulation of an enzymatic reaction mixture, the composition comprising a reaction component essential for an ex-vivo non-polymerase enzymatic reaction in which a substrate is catalyzed by an enzyme in a reaction mixture to form a product, and a tracer compatible with the enzyme, the composition being substantially free of the substrate.