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公开(公告)号:US07767212B2
公开(公告)日:2010-08-03
申请号:US11886577
申请日:2006-03-17
IPC分类号: A61K39/35 , A61K39/385 , C12N7/00 , C07K19/00 , C07K17/06
CPC分类号: A61K47/48776 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C07K2319/00
摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含病毒样颗粒(VLP)或病毒颗粒和至少一种抗原,特别是至少一种猫科动物抗原,更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中,抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物,特别是人类中诱导有效的免疫应答,特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备,特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。
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公开(公告)号:US20080019991A1
公开(公告)日:2008-01-24
申请号:US11628243
申请日:2005-06-02
申请人: Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人: Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC分类号: C12N7/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/525 , C07K2319/00 , C12N2710/00023 , C12N2730/10123 , C12N2795/00023
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒(VLP)。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号:US20070087409A1
公开(公告)日:2007-04-19
申请号:US11540969
申请日:2006-10-02
申请人: Martin Bachmann
发明人: Martin Bachmann
CPC分类号: A61K39/0005 , A61K38/00 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , C07K5/1021 , C07K7/14 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要: The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
摘要翻译: 本发明提供了哺乳动物肽激素血管紧张素原,血管紧张素I和血管紧张素II的肽衍生物的缀合物,其通过将肽衍生物偶联到载体,特别是病毒样颗粒(VLP)而呈现在重复的支架中。 本发明还提供了产生这种缀合物的方法,以及所得到的免疫原缀合物的免疫治疗用途,用于治疗和预防与肾素激活的血管紧张素系统相关的病症。
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公开(公告)号:US20060078554A1
公开(公告)日:2006-04-13
申请号:US10264267
申请日:2002-10-04
申请人: Martin Bachmann
发明人: Martin Bachmann
CPC分类号: A61K39/0005 , A61K38/00 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , C07K5/1021 , C07K7/14 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要: The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
摘要翻译: 本发明提供了哺乳动物肽激素血管紧张素原,血管紧张素I和血管紧张素II的肽衍生物的缀合物,其通过将肽衍生物偶联到载体,特别是病毒样颗粒(VLP)而呈现在重复的支架中。 本发明还提供了产生这种缀合物的方法,以及所得到的免疫原缀合物的免疫治疗用途,用于治疗和预防与肾素激活的血管紧张素系统相关的病症。
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公开(公告)号:US07785873B2
公开(公告)日:2010-08-31
申请号:US11589321
申请日:2006-10-30
申请人: Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人: Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC分类号: A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是RANKL蛋白,RANKL片段或RANKL肽-VLP阵列的组合物。 更具体地,本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白,RANKL片段或RANKL肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答,特别是抗体应答的药物。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号:US20070117129A1
公开(公告)日:2007-05-24
申请号:US11589321
申请日:2006-10-30
申请人: Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人: Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC分类号: A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是RANKL蛋白,RANKL片段或RANKL肽-VLP阵列的组合物。 更具体地,本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白,RANKL片段或RANKL肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答,特别是抗体应答的药物。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号:US20050002742A1
公开(公告)日:2005-01-06
申请号:US10728181
申请日:2003-12-04
申请人: Martin Bachmann
发明人: Martin Bachmann
CPC分类号: B05B7/1459 , B65G53/28
摘要: In a piston metering pump for supplying the atomizer of a powder coating machine, the vacuum generated in the pump chamber during the suction movement of the piston is reduced in controlled fashion by introducing transport air in order to reduce the powder throughput.
摘要翻译: 在用于供应粉末涂布机的雾化器的活塞计量泵中,在活塞抽吸运动期间在泵室中产生的真空通过引入输送空气以受控的方式减少,以便降低粉末生产量。
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公开(公告)号:US20110212122A1
公开(公告)日:2011-09-01
申请号:US12809261
申请日:2008-12-22
申请人: Martin Bachmann , Gary Jennings , Till Röhn
发明人: Martin Bachmann , Gary Jennings , Till Röhn
CPC分类号: C07K16/22 , A61K2039/5258 , A61K2039/6075 , A61K2039/62 , C07K14/48 , C07K2317/73 , C12N7/00 , C12N2795/00023 , C12N2795/18123
摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is NGF antigen. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of pain. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含与至少一种抗原连接的病毒样颗粒(VLP)的组合物,其中所述抗原是NGF抗原。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于疫苗的生产,特别是用于治疗疼痛。 此外,本发明的组合物诱导有效的免疫应答,特别是抗体应答。
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公开(公告)号:US20110045013A1
公开(公告)日:2011-02-24
申请号:US12785174
申请日:2010-05-21
CPC分类号: C07K14/005 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K2319/00
摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含病毒样颗粒(VLP)或病毒颗粒和至少一种抗原,特别是至少一种猫科动物抗原,更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中,抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物,特别是人类中诱导有效的免疫应答,特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备,特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。
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公开(公告)号:US20070093441A1
公开(公告)日:2007-04-26
申请号:US11499659
申请日:2006-08-07
申请人: Martin Bachmann , Gary Jennings , Ivo Sonderegger
发明人: Martin Bachmann , Gary Jennings , Ivo Sonderegger
CPC分类号: A61K39/0007 , A61K38/00 , A61K38/162 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/646 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2730/10142 , C12N2795/18122 , C12N2810/852
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇的组合物,特别是包含IL-5,IL-13或嗜酸细胞活化趋化因子的蛋白质或肽的阵列。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一种IL-5,IL-13和/或嗜酸性粒细胞趋化因子的蛋白质或肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用嗜酸性成分治疗过敏性疾病的疫苗和作为药物以预防或治愈嗜酸性成分的过敏性疾病并有效诱导免疫应答,特别是抗体应答的疫苗。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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