CAT allergen conjugates and uses thereof
    21.
    发明授权
    CAT allergen conjugates and uses thereof 有权
    CAT过敏原共轭物及其用途

    公开(公告)号:US07767212B2

    公开(公告)日:2010-08-03

    申请号:US11886577

    申请日:2006-03-17

    摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

    摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含病毒样颗粒(VLP)或病毒颗粒和至少一种抗原,特别是至少一种猫科动物抗原,更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中,抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物,特别是人类中诱导有效的免疫应答,特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备,特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

    Carrier Conjugates Of Tnf-Peptides
    22.
    发明申请
    Carrier Conjugates Of Tnf-Peptides 审中-公开
    Tnf肽的载体结合体

    公开(公告)号:US20080019991A1

    公开(公告)日:2008-01-24

    申请号:US11628243

    申请日:2005-06-02

    IPC分类号: A61K39/00 A61K45/00 C12N7/01

    摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒(VLP)。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Method and device for transporting powdery substances
    27.
    发明申请
    Method and device for transporting powdery substances 审中-公开
    运输粉状物质的方法和装置

    公开(公告)号:US20050002742A1

    公开(公告)日:2005-01-06

    申请号:US10728181

    申请日:2003-12-04

    申请人: Martin Bachmann

    发明人: Martin Bachmann

    IPC分类号: B65G53/28 B65G51/36

    CPC分类号: B05B7/1459 B65G53/28

    摘要: In a piston metering pump for supplying the atomizer of a powder coating machine, the vacuum generated in the pump chamber during the suction movement of the piston is reduced in controlled fashion by introducing transport air in order to reduce the powder throughput.

    摘要翻译: 在用于供应粉末涂布机的雾化器的活塞计量泵中,在活塞抽吸运动期间在泵室中产生的真空通过引入输送空气以受控的方式减少,以便降低粉末生产量。

    Nerve Growth Factor Conjugates and Uses Thereof
    28.
    发明申请
    Nerve Growth Factor Conjugates and Uses Thereof 审中-公开
    神经生长因子共轭体及其用途

    公开(公告)号:US20110212122A1

    公开(公告)日:2011-09-01

    申请号:US12809261

    申请日:2008-12-22

    摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is NGF antigen. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of pain. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.

    摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含与至少一种抗原连接的病毒样颗粒(VLP)的组合物,其中所述抗原是NGF抗原。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于疫苗的生产,特别是用于治疗疼痛。 此外,本发明的组合物诱导有效的免疫应答,特别是抗体应答。

    CAT Allergen Conjugates and Uses Thereof
    29.
    发明申请
    CAT Allergen Conjugates and Uses Thereof 审中-公开
    CAT过敏原共轭体及其用途

    公开(公告)号:US20110045013A1

    公开(公告)日:2011-02-24

    申请号:US12785174

    申请日:2010-05-21

    IPC分类号: A61K39/35 C12N7/00 A61P37/08

    摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

    摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含病毒样颗粒(VLP)或病毒颗粒和至少一种抗原,特别是至少一种猫科动物抗原,更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中,抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物,特别是人类中诱导有效的免疫应答,特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备,特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。