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26 条记录 (耗时 0.043 秒)

    Carrier Conjugates Of Tnf-Peptides
    3.
    发明申请
    Carrier Conjugates Of Tnf-Peptides 审中-公开
    Tnf肽的载体结合体

    公开(公告)号：US20080019991A1

    公开(公告)日：2008-01-24

    申请号：US11628243

    申请日：2005-06-02

    申请人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    发明人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    IPC分类号： A61K39/00 ,  A61K45/00 ,  C12N7/01

    CPC分类号： C12N7/00 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  C07K14/525 ,  C07K2319/00 ,  C12N2710/00023 ,  C12N2730/10123 ,  C12N2795/00023

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes
    6.
    发明申请
    Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes 审中-公开
    使用白细胞介素-1β突变蛋白偶联物治疗糖尿病

    公开(公告)号：US20130115189A1

    公开(公告)日：2013-05-09

    申请号：US13395099

    申请日：2010-09-09

    申请人： Martin F. Bachmann ,  Gunther Spohn ,  Patrik Maurer

    发明人： Martin F. Bachmann ,  Gunther Spohn ,  Patrik Maurer

    IPC分类号： A61K39/385

    CPC分类号： A61K39/385 ,  A61K39/0005 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  C07K14/545

    摘要： The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.

    摘要翻译： 本发明提供用于治疗，改善和/或预防II型糖尿病的组合物，药物组合物和疫苗。 本发明的组合物，药物组合物和疫苗包含RNA噬菌体和抗原的病毒样颗粒，其中所述抗原包含白细胞介素-1β（IL-1β）突变蛋白。 当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对IL-1β。 因此，本发明提供了通过对IL-1β的主动免疫来治疗，改善或预防II型糖尿病的方法。

    Vlp-Antigen Conjugates and Their Uses as Vaccines
    8.
    发明申请
    Vlp-Antigen Conjugates and Their Uses as Vaccines 失效
    Vlp抗原结合物及其用途作为疫苗

    公开(公告)号：US20080095738A1

    公开(公告)日：2008-04-24

    申请号：US11664716

    申请日：2005-10-05

    申请人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    发明人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P29/00 ,  A61P37/00 ,  A61K39/385

    CPC分类号： A61K39/0013 ,  A61K39/0005 ,  A61K39/0006 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/6075 ,  C12N2740/16211 ,  C12N2795/18123

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。