公开(公告)号：US10465044B2

公开(公告)日：2019-11-05

申请号：US15527484

申请日：2015-11-18

申请人： Matthew Becker ,  Howard Dean ,  Yuanyuan Luo

发明人： Matthew Becker ,  Howard Dean ,  Yuanyuan Luo

IPC分类号： C08G63/78 ,  C08G63/52 ,  C08G63/90 ,  A61L27/56 ,  B33Y70/00 ,  C08L67/06 ,  A61L27/18

摘要： Method for making poly(propylene fumarate) (PPF) polymer made by ring-opening polymerization of propylene oxide and maleic anhydride in the presence of magnesium ethoxide initiator, wherein PPF is specifically designed for us in 3D manufacturing of medical devices. PPF polymers have a number average molecular weight (Mn) of from about 450 Daltons to about 3400 Daltons; a molecular mass distribution (m) of from 1.0 to 2.0; and contains less than 1% w/w of poly(maleic anhydride-co-propylene oxide) polymer chains particularly. PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.

公开(公告)号：US20160250382A1

公开(公告)日：2016-09-01

申请号：US15032809

申请日：2014-10-29

申请人： Matthew Becker ,  Darrell Reneker ,  Yaohua Gao

发明人： Matthew Becker ,  Darrell Reneker ,  Yaohua Gao

IPC分类号： A61L27/18 ,  C08G71/02 ,  A61F2/82 ,  D01F6/68 ,  D01F6/84 ,  A61F2/07 ,  A61L27/58 ,  D01D5/00

摘要： Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5 mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts.

摘要翻译： 实施方案涉及具有选择L-亮氨酸，L-异亮氨酸，L-缬氨酸或其组合的氨基酸残基的氨基酸基聚（酯脲）。 基于氨基酸的聚（酯尿素）S可以任选地包括选自蛋白质氨基酸和非蛋白质氨基酸的第二氨基酸残基。 基于氨基酸的聚（酯尿素）对于制备血管移植物是特别有用的。 由于基于氨基酸的聚（酯尿素）的生物相容性，可以制备由具有小内径（即小于5mm）的氨基酸基聚（酯尿素）制备的血管移植物并将其插入患者 或动物，与血管移植物中使用的常规聚合物相比，可大大降低失败风险。

公开(公告)号：US20140171619A1

公开(公告)日：2014-06-19

申请号：US14122903

申请日：2012-05-25

申请人： Matthew Becker ,  Matthew Graham ,  Frank Harris ,  Fei Lin

发明人： Matthew Becker ,  Matthew Graham ,  Frank Harris ,  Fei Lin

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  C07K7/08

摘要： A method for creating a peptide crosslinked bioactive polymeric material includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.

摘要翻译： 用于产生肽交联的生物活性聚合物材料的方法包括使羟基官能化的小分子与氨基酸反应以形成氨基酸官能化单体，使氨基酸官能化单体与脲键形成物反应形成基于氨基酸的聚（ 酯脲），并使基于氨基酸的聚（酯尿素）与基于肽的交联剂反应以形成肽交联的生物活性聚合物材料。

公开(公告)号：US07365532B2

公开(公告)日：2008-04-29

申请号：US11394207

申请日：2006-03-31

申请人： Todd Hinck ,  Alan Fiedler ,  Matthew Becker ,  Georgios Asmanis ,  Jose Robins

发明人： Todd Hinck ,  Alan Fiedler ,  Matthew Becker ,  Georgios Asmanis ,  Jose Robins

IPC分类号： G01N27/82

CPC分类号： H04L43/12

摘要： In at least one embodiment an apparatus is provided that includes an electromagnetic coupler probe to provide sampled electromagnetic signals and an electronics component to receive the sampled electromagnetic signals from the electromagnetic coupler probe and to provide recovered sampled electromagnetic signals. Other embodiments may be described and claimed.

摘要翻译： 在至少一个实施例中，提供了一种装置，其包括电磁耦合器探针以提供采样的电磁信号，以及电子部件以接收来自电磁耦合器探针的采样的电磁信号并提供恢复的采样的电磁信号。 可以描述和要求保护其他实施例。

公开(公告)号：US06188249B1

公开(公告)日：2001-02-13

申请号：US09107310

申请日：1998-06-30

申请人： Matthew Becker

发明人： Matthew Becker

IPC分类号： H03K519

CPC分类号： G06F13/14 ,  G06F13/364

摘要： An asymmetric arbiter provides a fast signal path and a slow signal path. Signals may travel over the fast signal path in substantially less time than it takes for the signals to travel over the slow signal path. The fast signal path may be configured so as to impart only a minimal amount of delay. Signals that are to be frequently arbitrated by the arbiter may be applied to the fast signal path so as to minimize the delay introduced by the arbiter. The arbiter may include circuitry for detecting metastable conditions.

摘要翻译： 不对称仲裁器提供快速的信号路径和缓慢的信号路径。 信号可以以比信号在慢信号路径上行进所需的时间更短的时间在快速信号路径上行进。 快速信号路径可以被配置为仅施加最小量的延迟。 要被仲裁者频繁仲裁的信号可以应用于快速信号路径，以便最小化由仲裁器引入的延迟。 仲裁器可以包括用于检测亚稳态的电路。

公开(公告)号：US11987668B2

公开(公告)日：2024-05-21

申请号：US18005643

申请日：2021-07-15

申请人： Matthew Becker ,  Garrett Fredric Bass

发明人： Matthew Becker ,  Garrett Fredric Bass

IPC分类号： C08G63/83

CPC分类号： C08G63/83

摘要： In one or more embodiments, the present invention provides am method of making a poly(propylene fumarate-co-succinate) (PPFS) copolymer containing a random incorporation of succinate groups and targetable reduction profiles without the need for three or more monomer units. To achieve this, a time-dependent sonication-promoted zinc/acetic acid reduction of the PPM unsaturated double bonds has been used to create a random PPMS copolymer which may be isomerized into the PPFS equivalent. By changing the sonication time as well as the ratios of acetic acid, zinc, and PPM unsaturated alkenes, partial reduction of the PPM alkenes has been shown to give PPMS products containing varying compositions of succinic and maleate units, which may then be isomerized to the PPFS product.

公开(公告)号：US20230272159A1

公开(公告)日：2023-08-31

申请号：US18005643

申请日：2021-07-15

申请人： Matthew Becker ,  Garrett Fredric Bass

发明人： Matthew Becker ,  Garrett Fredric Bass

IPC分类号： C08G63/83

CPC分类号： C08G63/83

摘要： In one or more embodiments, the present invention provides am method of making a poly(propylene fumarate-co-succinate) (PPFS) copolymer containing a random incorporation of succinate groups and targetable reduction profiles without the need for three or more monomer units. To achieve this, a time-dependent sonication-promoted zinc/acetic acid reduction of the PPM unsaturated double bonds has been used to create a random PPMS copolymer which may be isomerized into the PPFS equivalent. By changing the sonication time as well as the ratios of acetic acid, zinc, and PPM unsaturated alkenes, partial reduction of the PPM alkenes has been shown to give PPMS products containing varying compositions of succinic and maleate units, which may then be isomerized to the PPFS product.

公开(公告)号：US11499008B2

公开(公告)日：2022-11-15

申请号：US16483122

申请日：2018-02-02

申请人： Matthew Becker ,  James A. Wilson ,  Yusheng Chen

发明人： Matthew Becker ,  James A. Wilson ,  Yusheng Chen

IPC分类号： C08G63/52 ,  C08G63/682 ,  C08G63/685 ,  C08G63/91 ,  C08G65/332 ,  C08L63/10 ,  C08G63/08 ,  C08G63/82 ,  C08G81/02 ,  B33Y70/00 ,  B33Y80/00 ,  A61L27/18

摘要： An end and monomer functionalized poly(propylene fumarate) polymer and methods for preparing this polymer, comprising isomerized residue of a maleic anhydride monomer and a functionalized propylene oxide monomer according to the formula: where n is an integer from more than 1 to 100; R is the residue of an initiating alcohol having a propargyl, norbornene, ketone or benzyl functional group; and R′ is a second functional group selected from the group consisting of propargyl groups, 2-nitrophenyl groups, and combinations thereof are disclosed. The end and monomer functional groups allow for post-polymerization modification with bioactive materials using “click” chemistries and use of the polymer for a variety of applications in medical fields, including, for example, 3-D printed polymer scaffold.

公开(公告)号：US09988492B2

公开(公告)日：2018-06-05

申请号：US15026069

申请日：2014-09-30

申请人： Matthew Becker ,  Fei Lin

发明人： Matthew Becker ,  Fei Lin

IPC分类号： A61K31/00 ,  C08G71/02 ,  C07C275/16 ,  C07C227/18 ,  C07C229/34 ,  C07C247/04 ,  C09D175/02

CPC分类号： C08G71/02 ,  C07C227/18 ,  C07C229/34 ,  C07C247/04 ,  C07C275/16 ,  C08G2230/00 ,  C09D175/02

摘要： Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickable” groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with Mw exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media.

公开(公告)号：US09745414B2

公开(公告)日：2017-08-29

申请号：US14939216

申请日：2015-11-12

申请人： Matthew Becker ,  Jiayi Yu

发明人： Matthew Becker ,  Jiayi Yu

IPC分类号： C08G63/685

CPC分类号： C08G63/685 ,  C08G83/005

摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.